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Browse the failure-mode index

21,733 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Chronic toxicity and uptake of 10 Per- and Polyfluoroalkyl Acids to marine species Americamysis bahia and Atherinops affinis.

Hayman NT, Pandelides Z, Colvin MA et al. · 2026 · Environmental toxicology and chemistry

A lack of marine specific data results in challenges to assessing site-specific ecological risks and developing marine water quality criteria for per- and polyfluoroalkyl substances (PFAS). Here, the toxicity and bioaccumulation of…

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Negative / Null Result ReportMedicine

Effective Coverage of Rehabilitation for Adults with Chronic Primary Low Back Pain in Uganda.

De Groote W, Taremwa Y, Duttine A et al. · 2026 · International journal of environmental research and public health

In Uganda, in 2019, 6.8 million people experienced health conditions that are amenable to rehabilitation. This is largely due to musculoskeletal disorders such as low back pain (LBP). Measuring effective coverage of rehabilitation means…

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Negative / Null Result ReportOpen accessMedicine

Awareness of Effective Communication Skills Among Paediatric Dentists in Turkey.

Büyüksefil M, Çimen Ü, Şimşek Derelioğlu S et al. · 2026 · Oral health & preventive dentistry

Purpose Effective communication with paediatric patients is one of the cornerstones of paediatric dentistry. Strong communication skills play a critical role in reducing dental anxiety, enhancing patient satisfaction, and facilitating the…

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Negative / Null Result ReportMedicine

Comparison of effective phacoemulsification times used in cataract surgery between the Veritas Vision System and the Centurion Vision System.

Choi JY, Song WS, Won YK et al. · 2026 · Korean journal of ophthalmology : KJO

Purpose To compare the effective phacoemulsification time used in cataract surgery and postoperative outcomes between the Veritas and the Centurion Vision System. Methods A retrospective analysis was conducted on 90 eyes from 82 patients…

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Negative / Null Result ReportMedicine

Effective population size and N e /N ratio for two populations of Northern chamois (Rupicapra rupicapra) on the edge of the species' distribution range.

Jacobs S, Edelhoff H, Ebert C et al. · 2026 · BMC ecology and evolution

Effective population size (Ne) is a fundamental parameter in conservation genetics, providing relevant information on the adaptability and long-term viability of populations. In contrast, wildlife management strategies, particularly for…

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Negative / Null Result ReportMedicine

Missed Opportunities for Timely Diagnosis and Effective Therapeutic Management of Prolonged Fever: A Case Study of Confirmed Lassa Fever in N'Zérékoré, Guinea, 2022.

Cherif IS, Essis EML, Diallo MA et al. · 2026 · Case reports in infectious diseases

Background Lassa fever is a potentially fatal viral hemorrhagic disease caused by a ribonucleic acid (RNA) virus of the Arenaviridae family, endemic in West Africa. It is highly virulent and contagious in several countries, with a…

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Failed Experiment ReportMedicine

Operative Cultures Rarely Necessitate Change to Periprosthetic Joint Infection Antibiotic Plan Based on Monomicrobial Preoperative Aspiration.

Ducharme MT, Elmenawi KA, Poilvache H et al. · 2026 · The Journal of arthroplasty

Introduction Periprosthetic joint infections (PJI) are complex to manage and frequently result in prolonged hospitalization while awaiting outpatient antibiotic therapy coordination. Moving this work to the preoperative setting for…

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Negative / Null Result ReportOpen accessMedicine

Vessel diameter as a potential predictor of pulsed dye laser response in port wine stain: a retrospective exploratory reflectance confocal microscopy study.

Ran X, Shang Y, Yang X et al. · 2026 · Lasers in medical science

To investigate whether noninvasive reflectance confocal microscopy (RCM)-derived vascular parameters can serve as objective predictors of therapeutic response to pulsed dye laser (PDL) treatment in patients with port wine stain (PWS),…

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Negative / Null Result ReportOpen accessMedicine

The Median Effective Dose of Phenylephrine Infusion for Prevention of Spinal-Induced Hypotension During Cesarean Delivery in the 15° Left-Tilt vs. Supine Positions: A Randomised Control Study.

Yu XQ, Drzymalski DM, Qian J et al. · 2026 · Drug design, development and therapy

Background Left uterine displacement is presumed to decrease vasopressor requirements during cesarean delivery due to decreased aortocaval compression, but studies have been equivocal. Our primary aim was to determine the median effective…

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Negative / Null Result ReportOpen accessMedicine

Drug supply shortages and their perceived consequences for patients: a questionnaire survey of German and Austrian physicians.

Rotter JM, Seifert R · 2026 · European journal of clinical pharmacology

Purpose Drug supply shortages are a recurring issue in developed countries, with consequences for patients even before the COVID-19 pandemic. Questions arise regarding the effectiveness and tolerability of alternative treatments chosen by…

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Methods Dead-EndOpen accessMedicine

Cost-effectiveness analysis based on two models of sacituzumab tirumotecan versus platinum-based chemotherapy as second-line treatment in EGFR-mutant non-small-cell lung cancer.

Jin L, Han L, Zeng J · 2026 · Frontiers in public health

Background For patients with advanced EGFR-mutant non-small cell lung cancer (NSCLC) who progress after first-line therapy, effective subsequent options are urgently needed. From the perspective of China's healthcare system, this study…

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Methods Dead-EndOpen accessMedicine

Cost utility and cost-effectiveness of the APPLE-Tree programme: Active Prevention in People at risk of dementia through Lifestyle, bEhaviour change and Technology to build REsiliEnce: economic evaluation embedded within a randomised controlled trial.

Demnitz-King H, Cooper C, Poppe M et al. · 2026 · Age and ageing

Background Previous studies have modelled long-term cost-effectiveness of dementia prevention but seldom within trials. APPLE-Tree (Active Prevention in People at risk of dementia through Lifestyle, bEhaviour change and Technology to build…

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Negative / Null Result ReportOpen accessMedicine

Pre-TIPS Liver and Spleen Volumetry Are Not Associated With Liver-Related Outcomes After TIPS Placement for Refractory Ascites.

Bedoya JU, Wagner M, Malézieux E et al. · 2026 · Liver international : official journal of the International Association for the Study of the Liver

Background & aims Transjugular intrahepatic portosystemic shunt (TIPS) improves survival in refractory ascites. A careful patient's selection is mandatory as TIPS can lead to complications. Liver volumetry is predictive of outcomes before…

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Abandoned HypothesisMedicine

Descriptive oxidative and lipid-related fluorescence observations associated with Esketamine treatment in a high-concentration NMDA-exposed HT-22/C8-D1A co-culture model.

Ni X, Zhou S, He X et al. · 2026 · Toxicology in vitro : an international journal published in association with BIBRA

Background In HT-22 cells, 500 μM NMDA was used as a high-concentration oxidative stressor rather than a classical NMDA receptor-mediated excitotoxic stimulus. Because HT-22 cells lack functional ionotropic NMDA receptors, this model…

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Negative / Null Result ReportMedicine

Early Endoscopic Retrograde Cholangiopancreatography is Associated With Improved Health Care Resource Utilization in Acute Biliary Pancreatitis Without Cholangitis.

Chu BK, Abdelbaki A, Nikahd M et al. · 2026 · Journal of clinical gastroenterology

Background The optimal timing for endoscopic retrograde cholangiopancreatography (ERCP) in managing uncomplicated acute biliary pancreatitis (ABP) remains unclear. This population-based study assessed the impact of ERCP timing on outcomes…

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