e-ISSN: Pending
Abandoned HypothesisMedicine

Descriptive oxidative and lipid-related fluorescence observations associated with Esketamine treatment in a high-concentration NMDA-exposed HT-22/C8-D1A co-culture model.

Ni X; Zhou S; He X; Wu K; Liang G; Wang A; Xu X · 2026 · Toxicology in vitro : an international journal published in association with BIBRA

WASTE classifies this as Abandoned Hypothesis · AI classification, approximate

A hypothesis was tested and not supported — a dead end worth knowing about before you pursue it.

Abstract (excerpt)

Background In HT-22 cells, 500 μM NMDA was used as a high-concentration oxidative stressor rather than a classical NMDA receptor-mediated excitotoxic stimulus. Because HT-22 cells lack functional ionotropic NMDA receptors, this model…

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Metadata source: Europe PMC · DOI 10.1016/j.tiv.2026.106274