Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Yan-Tao Ma, Yu-Lin Dong, Bo Wang et al. · 2023 · BMC Musculoskeletal Disorders
Abstract Background Latent and active myofascial trigger points (MTrPs) in knee-associated muscles may play a key role in pain management among patients with knee osteoarthritis (KOA). The aim of this study was to investigate the effect of dry needling treatment on pain intensity, disability, and range of motion (ROM) in patients with KOA. Methods This randomized, single-blinded, clinical trial was carried out for 6 weeks of treatment and 6-month follow-up. A total of 98 patients met the entry criteria and were randomly assigned to the dry needling latent and active myofascial trigger point (M
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Juan Duchesne, David McGreevy, Kristofer Nilsson et al. · 2020 · Journal of Endovascular Resuscitation and Trauma Management
Background: Resuscitative endovascular balloon occlusion of the aorta (REBOA) is becoming a standardized adjunct in the management of non-compressible hemorrhage. Ultrasound (US)-guided femoral access has been taught as the best practice for femoral artery cannulation. However, there is a lack of evidence to support its use in patients in extremis with severe hemorrhage. We hypothesize that no differences in outcome will exist between US-guided and to blind percutaneous or cutdown access methods. Methods: This was an international, multicenter retrospective review of all patients managed with
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Zahra Ojaghi-Haghighi, Atoosa Mostafavi, Hassan Moladoust et al. · 2015 · Journal of Tehran University Heart Center
Background: Left ventricular (LV) twist is due to oppositely directed apical and basal rotation and has been proposed as a sensitive marker of LV function. We sought to assess the impact of chronic pure mitral regurgitation (MR) on the torsional mechanics of the left human ventricle using tissue Doppler imaging. Methods: Nineteen severe MR patients with a normal LV ejection fraction and 16 non-MR controls underwent conventional echocardiography and apical and basal short-axis color Doppler myocardial imaging (CDMI). LV rotation at the apical and basal short-axis levels was calculated from the
View details →Negative / Null Result ReportOpen accessSurgery
Mohamed Nasr, Moustafa AH El-Nawasany, Haytham E Ali et al. · 2025 · JPRAS Open
Background: Diabetic foot ulcers (DFUs) are a serious complication of diabetes that can lead to significant morbidity. Autologous platelet-rich plasma (PRP), rich in growth factors and cytokines, has emerged as a promising treatment to enhance ulcer healing. This study aimed to compare the clinical and histological efficacy of injected PRP versus topically applied PRP and traditional wound care in the management of DFUs. Methods: Sixty patients with DFUs were randomly assigned to three equal groups (n = 20 each). Group A received locally injected autologous PRP; Group B received topically appl
View details →Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Yongzhao Fan PhD, Linlin Zhang PhD, Xiaoyang Kong MD et al. · 2022 · American Journal of Alzheimer's Disease and Other Dementias
Background Previous studies have demonstrated that pre-exercise suppresses anxiety-like behavior, but the effects of different exercise times on vascular dementia induced anxiety-like behavior have not been well investigated. Objective The present study aims to investigate the underlying neurochemical mechanism of different pre-vascular-dementia exercise times on 5-HT and anxiety-like behavior in rats with vascular dementia. Methods 32 Sprague-Dawley (SD) rats were randomly divided into 4 groups: sham group (S group, n = 8), vascular dementia group (VD group, n = 8), 1-week physical exercise a
View details →Negative / Null Result ReportOpen accessMedicine (General)
Hongseok Yoo, Jimi Oh, Chul Park · 2020 · Military Medical Research
Abstract Background In 2014, an outbreak of adenoviral pneumonia occurred in the Korean military training center. However, there are limited data on the characteristics of the fever and its response to antipyretic therapy in immunocompetent adults with adenovirus-positive community-acquired pneumonia (CAP). Methods The medical records of the patients who were admitted to the Armed Forces Chuncheon Hospital for the treatment of CAP between January 2014 and December 2016 were retrospectively analyzed. The patients were divided into three groups, namely, the adenovirus-positive (Adv) group, the a
View details →Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Tomoko Hyakumura, Tomoko Hyakumura, Ulises Aregueta-Robles et al. · 2021 · Frontiers in Neuroscience
Active implantable neurological devices like deep brain stimulators have been used over the past few decades to treat movement disorders such as those in people with Parkinson’s disease and more recently, in psychiatric conditions like obsessive compulsive disorder. Electrode-tissue interfaces that support safe and effective targeting of specific brain regions are critical to success of these devices. Development of directional electrodes that activate smaller volumes of brain tissue requires electrodes to operate safely with higher charge densities. Coatings such as conductive hydrogels (CHs)
View details →Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
C. Archili, P. Lissoni, G. Cattaneo et al. · 1990 · The International Journal of Biological Markers
The biological significance of soluble IL-2 receptors (sIL-2R) is still unknown; in particular, it is not yet clear whether their increase in the blood may reflect activation of immune cells, or whether it is related to an immune dysfunction. To investigate this problem, we evaluated serum levels of sIL-2R before and after administration of a highly lymphocytolitic chemotherapy (FEC: fluorouracil, epirubicin, cyclophosphamide) in a group of 6 patients with advanced breast cancer. SIL-2R were analyzed in relation to lymphocyte number. Absolute mean number of lymphocytes was significantly lower
View details →Negative / Null Result ReportOpen accessOphthalmology
Ritu Mali, Smruti R. Priyadarshini, Srikant K. Sahu et al. · 2024 · Indian Journal of Ophthalmology
Purpose: To compare the visual outcomes, postoperative complications, and graft asymmetry between precut and manually dissected donor tissues for Descemet stripping automated endothelial keratoplasty (DSAEK) and Descemet stripping endothelial keratoplasty (DSEK) procedures, respectively. Methods: Seventy eyes of 70 patients undergoing DSEK/DSAEK at a tertiary eyecare center in eastern India were included in this prospective randomized control study. The 70 eyes were divided equally into two groups. Group A (n = 35) and Group B (n = 35) underwent DSEK and DSAEK procedures, respectively. the ope
View details →Negative / Null Result ReportOpen accessInfectious and parasitic diseases
Amira Al Balakosy, Mostafa Alfishawy, Omnia Elnabawy et al. · 2021 · Afro-Egyptian Journal of Infectious and Endemic Diseases
Background and study aim: Epidemiological data reported lower death rates of COVID-19 cases in countries with higher & recent coverage by measles containing vaccines. In this study we aim to identify measles IgG titer in COVID-19 patients & correlate it with disease severity. Patients and Method: This is a Cross-sectional study where 78 patients admitted to Ain Shams University Quarantine hospitals with positive PCR for SARS-CoV-2 were enrolled. All patients underwent quantification of serum measles IgG titer. Then classified according to the COVID-19 severity into mild, moderate and
View details →Negative / Null Result ReportOpen accessMedicine
fatemeh marhemati, reza mir arab razi, mostafa azizi · 2020 · آموزش پزشکی
Background and Objective: Creating and developing self-directed learning skills has become one of the goals of education in recent decades, and today's students need to learn and acquire comprehensive information in this regard, or better to say, learn information and communication technology skills, to Be able to use electronic services. The purpose of this study was to investigate the relationship between electronic citizenship knowledge and self-directed learning of students of University of Mazandaran and Babol University of medical sciences. Methods: This study is descriptive-analytical i
View details →Negative / Null Result ReportOpen accessPediatrics
Roberto Teggi, Bruno Colombo, Marco Familiari et al. · 2023 · Frontiers in Pediatrics
IntroductionVestibular impairment and vertigo in the pediatric population have an estimated prevalence ranging between 0.4% and 5.6% and are a topic of interest in recent years. The Bárány Society has recently reclassified migraine-related vertigo syndromes as vestibular migraine of childhood (VMC), probable vestibular migraine of childhood (probable VMC), and recurrent vertigo of childhood (RVC).MethodsApplying the criteria established by the Bárány Society, we retrospectively analyzed data on 95 pediatric patients suffering from episodic vertigo that were recruited from 2018 to 2022. In appl
View details →Negative / Null Result ReportOpen accessGynecology and obstetrics
Fedora Ambrosetti, MD, Giovanni Grandi, MD, Elisabetta Petrella, MD et al. · 2023 · AJOG Global Reports
BACKGROUND: The use of epidural analgesia represents the gold standard for pain management during labor, but the influence of the use of epidural analgesia on delivery mode is not fully understood. OBJECTIVE: This study aimed to analyze the impact of epidural analgesia on the delivery mode, namely, cesarean delivery, vaginal delivery, and operative vaginal delivery rates, in Robson class 1 women. STUDY DESIGN: A retrospective cohort study was conducted on all Robson class 1 women who delivered from January 1, 2019, to December 31, 2019, in the University Hospital of Modena. The primary outcome
View details →Negative / Null Result ReportOpen accessSports medicine
JL Ayers, M DeBeliso, TG Sevene et al. · 2016 · Biology of Sport
Olympic weightlifting movements and their variations are believed to be among the most effective ways to improve power, strength, and speed in athletes. This study investigated the effects of two Olympic weightlifting variations (hang cleans and hang snatches), on power (vertical jump height), strength (1RM back squat), and speed (40-yard sprint) in female collegiate athletes. 23 NCAA Division I female athletes were randomly assigned to either a hang clean group or hang snatch group. Athletes participated in two workout sessions a week for six weeks, performing either hang cleans or hang snatc
View details →Replication Failure
Nwafor Chimuanya Leonard, Dr. Dike · 2018
Task Hierarchy Analysis Model in Cooperative Learning Strategy and Chemistry Students’ Performance were investigated in Nwangele Local Government Area of ImoState. Two objectives, two research questions and two hypotheses guided the study.…
View details →Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Alsubaie SS · 2025 · Neuropsychiatric Disease and Treatment
Sultan Saad Alsubaie Department of Psychiatry, Armed Forces Hospital, Khamis Mushayt, Saudi ArabiaCorrespondence: Sultan Saad Alsubaie, Consultant Psychiatrist, psychiatry department, Armed Forces Hospital Southern Region, P.O. Box 101, Khamis Mushayt, Saudi Arabia, Tel +96-6503799971, Email dr.slt4444@gmail.comPurpose: This study aims to compare self-esteem and social anxiety disorder (SAD) symptoms levels between visually impaired and sighted individuals, and to explore the relationship between social anxiety and various sociodemographic factors.Materials and Methods: A case-control study wa
View details →Negative / Null Result ReportOpen accessAnimal culture
P. P. Singh, Ashok Kumar, R. S. Chauhan et al. · 2016 · Veterinary World
Aim: The present study was aimed to investigate the immunological competence of chlorpyrifos (CPF) insecticide after oral administration in layer chickens. Materials and Methods: A total of 20 White Leghorn birds were given CPF in drinking water at 0.3 ppm/bird/day (no observable effect level dose) for a period of 3-month. Immune competence status of layer birds and chicks hatched from CPF-treated birds were estimated at 15 days interval in layer birds and monthly interval in chicks using immunological and biochemical parameters. Results: There was a significant decrease in values of total leu
View details →Negative / Null Result ReportOpen accessSurgery
Ahmet Adnan Cırık, Yeşim Esen Yiğit, Ahmet Mahmut Tekin et al. · 2024 · Frontiers in Surgery
PurposeThis study aimed to assess the readability indices of websites including educational materials on otosclerosis.MethodsWe performed a Google search on 19 April 2023 using the term “otosclerosis.” The first 50 hits were collected and analyzed. The websites were categorized into two groups: websites for health professionals and general websites for patients. Readability indices were calculated using the website https://www.webfx.com/tools/read-able/.ResultsA total of 33 websites were eligible and analyzed (20 health professional-oriented and 13 patient-oriented websites). When patient-orie
View details →Negative / Null Result ReportOpen accessMedicine
Justin Fulkerson, MSN, Robert Lowe, BSN, Tristan Anderson, BSN et al. · 2016 · Western Journal of Emergency Medicine
Introduction: This study compared the effects of vasopressin via tibial intraosseous (IO) and intravenous (IV) routes on maximum plasma concentration (Cmax), the time to maximum concentration (Tmax), return of spontaneous circulation (ROSC), and time to ROSC in a hypovolemic cardiac arrest model. Methods: This study was a randomized prospective, between-subjects experimental design. A computer program randomly assigned 28 Yorkshire swine to one of four groups: IV (n=7), IO tibia (n=7), cardiopulmonary resuscitation (CPR) + defibrillation (n=7), and a control group that received just CPR (n=7).
View details →Negative / Null Result ReportOpen accessMedicine (General)
Zhen Yu Jia, Yuan Yuan Jiang, Jung Min Woo et al. · 2018 · Neurointervention
Purpose Wide-neck aneurysms (WNAs) associated with a dilated parent artery (PA) are not uncommon morphological abnormalities and usually cause inappropriate wall apposition and incomplete neck coverage of a tubular stent in stent-assisted coiling of aneurysms. We aimed to introduce a fusiform-shaped stent (FSS) and test its effectiveness in treating intracranial WNAs associated with a dilated PA using a three-dimensional (3D) model. Materials and Methods Two FSS types were designed with the middle one-third segment dilated by 10% (FSS10) and 20% (FSS20) and were compared with the tubular-shape
View details →Negative / Null Result ReportOpen accessPublic aspects of medicine
Said Kara · 2022 · Journal of Public Health in Africa
Background. The purpose of this study was to investigate the connection between self-efficacy and treatment adherence, working on the assumption that self-efficacy plays a role in determining treatment adherence in chronic diseases. Hypertension affects one-third of the world’s population. In Africa, hypertension is a leading cause of death from a non-communicable disease. Modifications to lifestyle and behavior, as well as increased access to pharmaceuticals, are necessary for every African nation to bring the prevalence of hypertension and cardiovascular disorders under control. Methods. In
View details →Negative / Null Result ReportOpen accessNuclear engineering. Atomic power
Junhyuk Jang, Minsoo Lee, Gha-Young Kim et al. · 2025 · Nuclear Engineering and Technology
Copper oxidation at low temperatures below 140 °C and its effects on corrosive behavior in aerobic groundwater are investigated to estimate the intactness of canisters at early stages of disposal. The Cu coupon surface is covered by fine particles that form thin oxide layers after 30 d of oxidation; a thin Cu2O layer of thickness <100 nm is formed after oxidation at 40 °C; after oxidation at 140 °C, the Cu2O surface changes to a CuO layer of thickness <500 nm. The thickness of the Cu surface oxidized at 90 °C is between those of the surfaces oxidized at 40 and 140 °C. All Cu coupons exhibit si
View details →Negative / Null Result ReportOpen accessMedicine
Zainab Y. Ejam, Şevki Adem, Asmaa Kadhim Gatea · 2024 · Medical Journal of Babylon
Background: Vascular endothelial growth factor (VEGF) is crucial for the implantation of a fertilized egg and for the development of placental blood vessels. This study was conducted to detect the serum VEGF level of pregnant with different types of assisted reproductive techniques in relation to the age group, body mass index (BMI), and type of infertility. Objectives: The aim of this study was to determine the levels of serum VEGF in different types of assisted pregnancy. Materials and Methods: Enzyme-linked immunosorbent assay was used for the detection of VEGF levels in the serum of pregna
View details →Negative / Null Result ReportOpen accessSports medicine
Iraj Hoseinzade, Ahmad Abdi, Asieh Abbassi Daloii · 2022 · فیزیولوژی ورزش و فعالیت بدنی
Background and Purpose: Fat tissue, frequently the largest organ in humans, is at the nexus of mechanisms involved in longevity and age-related metabolic dysfunction. Fat distribution and function change dramatically throughout life. Obesity is a major risk factor for development of comorbidities such as type-2 diabetes, neurological disorders, osteoarthritis, cancer, cardiovascular and renal diseases, which is associated with increased senescent cell and heart disorders. Exercise training and natural supplements constitute an indispensable, tool in the management of obesity and obesity-relate
View details →Negative / Null Result ReportOpen accessBiotechnology
Tomáš Svoboda, Daniel Ruman, Milan Gaff et al. · 2015 · BioResources
The influence of selected factors, such as wood species, veneer combinations, and loading cycles, on the bending strength and modulus of elasticity of glued laminated wood was investigated after cyclic loading of 0, 1000, 3000, and 7000 cycles with European beech (Fagus sylvatica (L.)) and Eurasian aspen (Populus tremula (L.)) The laminated woods were created by a combination of densified and non-densified veneers. The 30% densification was carried out by cold rolling. All factors and their interactions had statistically significant influence on the modulus of elasticity. Similarly, the influe
View details →Negative / Null Result ReportOpen accessVeterinary medicine
Tytti Maaria Niemelä, Riitta-Mari Tulamo, Jorge Uriel Carmona et al. · 2019 · Acta Veterinaria Scandinavica
Abstract Background Inflammatory and degenerative activity inside the joint can be studied in vivo by analysis of synovial fluid biomarkers. In addition to pro-inflammatory mediators, several anabolic and anti-inflammatory substances are produced during the disease process. They counteract the catabolic effects of the pro-inflammatory cytokines and thus diminish the cartilage damage. The response of synovial fluid biomarkers after intra-articular hyaluronan injection, alone or in combination with other substances, has been examined only in a few equine studies. The effects of hyaluronan on som
View details →Negative / Null Result ReportOpen accessPharmacy and materia medica
Saeid Abbasi-Maleki, Hadi Yousefi*, Rahim Sharafkhani et al. · 2023 · Research Journal of Pharmacognosy
Background and objectives: Earlier researches have exhibited the antioxidant, antinociceptive, and antiepileptic effects of Ferula gummosa. Considering that antioxidants play a key role in the pathogenesis of depression, the antidepressant potential of the F. gummosa essential oil was assessed by using a mouse models. Methods:Lorke’s method was used to access the acute toxicity of the F. gummosa essential oil. The F. gummosa essential oil (5-40 mg/kg), standard agents, and vehicle were administered to animals. The forced-swimming test (FST), tail suspension test (TST), and open-field test (OFT
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Muzaffar Ali, Deepak Padmanabhan, Khalil Kanjwal et al. · 2021 · Journal of Arrhythmia
Abstract Background Fluoroscopic imaging involves exposure of the patients and the laboratory staff to ionizing radiation. One of the strategies that reduce such exposure in an electrophysiology laboratory is using a three‐dimensional electroanatomic mapping (3D EAM) system for performing these procedures. In this analysis, we have analyzed the effect of fluoroscopy frame rate on the radiation exposure and in‐hospital outcomes in ablation procedures performed under 3D EAM guidance. Methods We retrospectively analyzed all the ablation procedures performed under 3D EAM guidance at our institute
View details →Negative / Null Result ReportOpen accessNutrition. Foods and food supply
Chen Xinyan, Wu Yajie, He Shangfan et al. · 2025 · Nutrition & Metabolism
Abstract Intermittent fasting (IF) as a dietary intervention with potential health benefits has garnered significant attention in recent years. This study investigated the effects of varying fasting intensities on skeletal muscle growth using mouse models. Compared to the normal-diet (ND) control group, short-term fasting induced feeding amount-dependent alterations in skeletal muscle autophagy markers, characterized by elevated LC3B expression, reduced p62 levels, and decreased p-mTOR/mTOR ratio. Notably, short-term mild fasting (sMF) significantly upregulated myogenic (MYH, MyoD) and adipoge
View details →Negative / Null Result ReportOpen accessMedicine
Hakan Hasman, Orhan Cinar, Ahmet Uzun, Erdem Cevik, Loni Jay, Bilgin Comert · 2012 · International Journal of Medical Sciences
Study objective: To compare the effect of normal saline (NS), lactated Ringer's, and Plasmalyte on the acid-base status of dehydrated patients in the emergency department (ED). Method: We conducted a prospective, double-blind, randomized trial of consecutive adult patients who presented to the emergency department with moderate-severe dehydration. Patients were randomly allocated to blindly receive normal saline (NS), lactated Ringer's or Plasmalyte at 20 ml/kg/h for 2 hours. Outcome measures of the study were pH and changes in electrolytes, including serum potassium, sodium, chloride and bica
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