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Browse the failure-mode index

21,720 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Is selenate a diabetogenic form of selenium? Evidence from a natural experiment in Northern Italy.

Vinceti M, Vicentini M, Ottone M et al. · 2026 · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

Background Consistent evidence from randomized controlled trials has shown that overexposure to selenium induces type 2 diabetes. However, uncertainties remain about the specific species and doses of selenium that trigger such diabetogenic…

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Negative / Null Result ReportMedicine

Geomagnetic Constraints on Millicharged Dark Matter.

Arza A, Gong Y, Shu J et al. · 2026 · Physical review letters

Millicharged particles are well-motivated dark matter candidates arising in many extensions of the standard model. We show that, despite their tiny coupling e_{m} to photons, millicharged dark matter (mDM) in the Earth's geomagnetic field…

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Negative / Null Result ReportMedicine

Association of oral metoprolol exposure during heart failure hospitalization with death or readmission at 28-days and 6-months using a propensity score overlap-weighted EHR analysis.

Ishaqui AA, Alsaleh EA, Khalil AAA et al. · 2026 · Naunyn-Schmiedeberg's archives of pharmacology

Heart failure (HF) hospitalization is a high-risk transition period with frequent early post-discharge events; we evaluated whether oral metoprolol exposure during the index HF hospitalization is associated with lower all-cause death…

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Negative / Null Result ReportOpen accessMedicine

No Evidence That Women's Sociosexuality or Self-Perceived Mate Value Predict Their Preferences for Men's Face-Shape Masculinity.

Lee P, Li J, Jones BC et al. · 2025 · Evolutionary psychology : an international journal of evolutionary approaches to psychology and behavior

Researchers have suggested that men with more masculine facial characteristics have stronger immune systems but are perceived to be less likely to invest resources in partners and offspring. How women resolve this putative trade-off…

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Negative / Null Result Report

The individual and combined impacts of school-based water, sanitation, and hygiene (WASH) education and infrastructure operation and maintenance (O&M): A factorial cluster-randomized controlled trial in Uttar Pradesh, India

Hornsby G, Pu C, Badamikar A et al. · 2025 · Preprint

ABSTRACT Introduction While improving water, sanitation, and hygiene (WASH) service delivery in schools supports the Sustainable Development Goals, rigorous trials have recently reported inconsistent effects of WASH in schools (WinS)…

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Negative / Null Result ReportOpen accessMedicine

Foetal Exposure to Phthalates and Endocrine Effects on the Leydig Cell.

Nielsen SP, Mathiesen L, Møller P · 2025 · Basic & clinical pharmacology & toxicology

This review examines the association between early life exposure to phthalates in human males and Leydig cell endocrine function. A systematic search was performed in PubMed and EMBASE, identifying 17 studies for analysis. Association…

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Negative / Null Result ReportOpen accessMedicine

Causal effects of single-carbon metabolism and vitamin levels on autism spectrum disorder risk: a bidirectional Mendelian randomized study.

Zhu J, Yi Y, Ma L et al. · 2026 · Italian journal of pediatrics

BACKGROUND: Observational epidemiology studies suggested a relationship between single-carbon metabolism and vitamin levels with autism spectrum disorder (ASD) risk. We aimed to explore the causal relationship between them at the genetic…

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Negative / Null Result ReportMedicine

The association between residential natural vegetation exposure at diagnosis and colorectal cancer-specific mortality among colorectal cancer cases in Kentucky.

Newton JD, Ellis T, Ruther M et al. · 2026 · Environmental research

Living near green areas with high vegetation may contribute to an active lifestyle, stress reduction, and enhance social cohesion, and consequently may be associated with improved cancer survival. Epidemiologic studies focused on greenness…

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Negative / Null Result ReportOpen accessMedicine

The Effect of Myo-Inositol Supplementation During Pregnancy on Fetal and Maternal Outcomes: Results of the Myo-Inositol for the Prevention of Gestational Diabetes Mellitus (MiGDM) Randomized Double-Blind, Placebo-Controlled Pilot Trial.

Okunoye G, George Samuel C, Abdullahi H et al. · 2026 · Cureus

Gestational diabetes mellitus (GDM) is a common pregnancy complication with significant maternal and neonatal risks, and its prevalence is particularly high in Qatar. Myo-inositol has been proposed as an insulin-sensitizing supplement that…

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