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Browse the failure-mode index

21,287 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

The Effect of External Distractions on Simulated Laparoscopic Performance.

Ingram I, Hughes MA · 2024 · Journal of laparoendoscopic & advanced surgical techniques. Part A

Background: Surgeons are exposed to unavoidable distractions while operating. Distractions can cause stress, and stress can impair cognition and motor skills to the detriment of surgeon performance. This study assessed the impact of…

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Negative / Null Result ReportOpen accessMedicine

Evaluating the risk of atrial fibrillation in patients with chronic recurrent pericarditis prescribed colchicine: Observations using TriNetX global federated research network.

Kaşkal M, Bucci T, Alobaida M et al. · 2025 · European journal of clinical pharmacology

BACKGROUND: Chronic pericarditis is associated with significant cardiovascular morbidity, including atrial fibrillation (AF), heart failure (HF), and stroke. Colchicine is widely used in pericarditis management for its anti-inflammatory…

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Negative / Null Result ReportOpen accessMedicine

Surveillance after treatment for head and neck cancer.

Koivunen P · 2026 · Current opinion in otolaryngology & head and neck surgery

Purpose of review Systematic follow-up protocols, often including regular imaging, are an essential component of posttreatment care for head and neck cancer, aimed at the early detection of disease relapse and mitigating treatment-related…

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Negative / Null Result ReportOpen accessMedicine

Hyperthermic intraperitoneal chemotherapy plus SOX chemotherapy versus SOX chemotherapy alone in patients with gastric cancer and peritoneal metastasis: a phase II randomized clinical trial.

Luo L, Zhang Z, Zeng H et al. · 2025 · Journal of gastrointestinal oncology

Background The prognosis of patients with gastric cancer with peritoneal metastasis (GCPM) is exceedingly poor. This study evaluated the efficacy and safety of hyperthermic intraperitoneal chemotherapy (HIPEC) with paclitaxel combined with…

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Negative / Null Result ReportOpen accessMedicine

Absence of lipopolysaccharide (LPS) expression in breast cancer cells.

de Miranda NFCC, Smit VTHBM, van der Ploeg M et al. · 2025 · Cellular oncology (Dordrecht, Netherlands)

The relationship between bacterial activity and tumorigenesis has gained attention in recent years, complementing the well-established association between viruses and cancer. A recent study employed immunodetection of lipopolysaccharide…

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Negative / Null Result ReportOpen accessMedicine

Use of baloxavir as adjunctive antiviral therapy to neuraminidase inhibitors in severely immunocompromised individuals infected with influenza.

Vetter P, Cabecinhas ARG, Schibler M et al. · 2026 · Antimicrobial agents and chemotherapy

Immunocompromised patients are at risk of developing severe influenza, with protracted viral shedding and development of resistance-associated mutations under antiviral treatment. We report a case series of severely immunocompromised…

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Negative / Null Result ReportMedicine

Leukocyte-Poor Platelet-Rich Plasma as a Treatment for Patellar Tendinopathy A Multicenter, Randomized Controlled Trial.

Herrero C, Wasterlain A, Bloom DA et al. · 2024 · Bulletin of the Hospital for Joint Disease (2013)

Purpose The purpose of this study was to compare regimens of eccentric exercise and dry-needling, with and without an ultrasound-guided leukocyte-poor platelet-rich plasma (LP-PRP) injection, in patients with patellar tendinopathy. Methods…

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Negative / Null Result ReportOpen accessMedicine

An analytical observational study for diagnostic accuracy of volume, conductivity & scatter (VCS) indices of neutrophils for diagnosis of sepsis in an emergency hospital setting.

Bharti A, Palta A, Bedi RK et al. · 2024 · The Indian journal of medical research

Background & objectives The newer technique using an innovative volume conductivity scatter (VCS) technology is emerging as a surrogate for sepsis diagnosis. The VCS technology offers a more objective method to measure cell volume (V),…

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Negative / Null Result ReportOpen accessMedicine

In Vitro Assessment of the Potential Effect of Vertical Peri-Implant Soft Tissue Thickness on Nonsurgical and Surgical Implant Surface Decontamination Methods.

Rahner A, Eickholz P, Gueth JF et al. · 2025 · Clinical oral implants research

Objectives In vitro analysis of the influence of vertical peri-implant soft tissue thickness (STT) on nonsurgical and surgical implant surface decontamination efficacy. Material and methods A total of 360 implants were dipped in indelible…

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Negative / Null Result ReportMedicine

Comparison of computed tomography findings between perianal tumors originating from the anal sacs and perianal glands in dogs.

Jeong J, Goh J, Nam C et al. · 2025 · Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association

Tumors originating from the anal sacs and perianal glands are common tumors of the perianal region. However, differentiation of perianal tumors based on CT findings remains challenging because perianal tumors can show overlapping CT…

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Failed Experiment ReportMedicine

Translating Pharmacokinetic-Pharmacodynamic Principles Into Improved Methodology for Clinical Trials That Compare Intermittent With Prolonged Infusion of Beta-Lactam Antibiotics.

Tilanus AM, Shields RK, Lodise TP et al. · 2025 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Based on the fact that beta-lactam antibiotics demonstrate time-dependent killing, different dosing strategies have been implemented to increase the time that free (unbound) antibiotic concentrations remain above the minimal inhibitory…

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Negative / Null Result ReportOpen accessMedicine

An Observational Study on Clinical Insights and Outcome Prediction of Lupus Enteritis in Indian Systemic Lupus Erythematosus Patients.

Kotha S, Baisya R, Yerram KV et al. · 2025 · Mediterranean journal of rheumatology

Background Lupus enteritis (LE) is the most common serious gastrointestinal manifestation of SLE. Indian literature on LE is limited, while most of the data comes from China and Western series with recent efforts on developing prediction…

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Negative / Null Result ReportOpen accessMedicine

An atypical manifestation of Giant cell arteritis (GCA): constitutional symptoms & lingual ulcer in a 78-Year-Old male with negative temporal artery biopsies.

Gow J, Roofeh D · 2025 · BMC rheumatology

Background Giant cell arteritis (GCA) is a large vessel vasculitis characterized by granulomatous inflammation classically affecting the carotid artery branches. GCA most often presents with one or more classic clinical features which…

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Negative / Null Result ReportMedicine

Long-term impact of posterior reconstruction urethrovesical anastomosis during robot-assisted prostatectomy A secondary analysis of a randomized cohort.

Millan B, Hoogenes J, Uy M et al. · 2025 · Canadian Urological Association journal = Journal de l'Association des urologues du Canada

Introduction We aimed to assess early and late continence rates post-robot-assisted radical prostatectomy (RARP), comparing posterior reconstruction (PR) urethrovesical anastomosis (UVA) to conventional urethrovesical anastomosis (C-UVA).…

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Negative / Null Result ReportOpen accessMedicine

Children with Dyslexia Benefit from Short Combined Reading and Motor Training: Objective Measures Assessed by Eye Movements and Postural Sway Recordings.

Caldani S, Khoury E, Delorme R et al. · 2025 · Brain sciences

Background/Objectives: Children with dyslexia report poor motor control; several studies have shown poor eye movements control during reading and important body instability in these children. The present study aimed to test in children…

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Negative / Null Result ReportOpen accessMedicine

Analysing the clinical outcomes between FIGO 2009 and 2023 staging for endometrial cancer-a single institution retrospective study.

Vuppu DP, Rajanbabu A, Nair IR et al. · 2025 · Ecancermedicalscience

The latest International Federation of Gynaecology and Obstetrics (FIGO) staging for endometrial cancer incorporated molecular profiles and histopathological factors into the basic staging framework. This study was done to determine its…

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