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Browse the failure-mode index

21,720 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

A microplastic meal: A baseline assessment of microplastic polymer presence within manta-ray (Mobula alfredi) feeding grounds at D'Arros Island and the St. Joseph Atoll.

Choppy MT, Duncan MI, Gordon N et al. · 2026 · Marine pollution bulletin

Microplastic ingestion by reef manta rays (Mobula alfredi) is a threat to their health and population stability. Seychelles' outer islands are vital habitats for M. alfredi but nothing is known about marine microplastic pollution in the…

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Negative / Null Result ReportMedicine

The effect of physiological changes in estradiol hormone during the follicular phase of the menstrual cycle in healthy women on retinal ganglion cell function, retinal and optic nerve vascularization and structure.

Hamurcu M, Gültekin BP, Göçmen M et al. · 2026 · Documenta ophthalmologica. Advances in ophthalmology

Purpose This study aimed to investigate the effects of estradiol changes occurring during the early follicular phase of the menstrual cycle on retinal ganglion cell function, retinal and optic nerve vascularity and structure in healthy…

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Negative / Null Result ReportMedicine

No Association Between Anatomic Factors and Non-Contact ACL Injury Risk in 217 Female Team Sport Players: A Prospective 4.5-Year Study.

Leppänen M, Jarske H, Krosshaug T et al. · 2026 · Scandinavian journal of medicine & science in sports

The purpose of this explorative study was to investigate the association between anatomic factors and risk for non-contact anterior cruciate ligament (ACL) injuries among female team sport players. A total of 225 players from basketball,…

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Negative / Null Result ReportMedicine

Visual Outcomes and the Impact of Intermediate Segment Orientation on the Performance of an Asymmetric Multifocal Intraocular Lens.

McLintock C, Uprety S, McKelvie J et al. · 2026 · Journal of refractive surgery (Thorofare, N.J. : 1995)

Purpose To evaluate the visual outcomes and the impact of intermediate segment orientation on the performance of an asymmetric multifocal intraocular lens (IOL) in patients who have cataract. Methods In this retrospective single-center…

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Negative / Null Result ReportMedicine

Understanding AI adoption in medical education: Insights from students and faculty members in Indonesian medical schools.

Rujito L, Muhaimin A, Pergodi MA et al. · 2026 · Journal of education and health promotion

Background Artificial Intelligence (AI) implementation in medical education has changed the learning process, with new forms of diagnosis, treatment planning, and patient care. Biases in AI adoption among Indonesian medical schools'…

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Negative / Null Result ReportMedicine

Connectedness to Nature, Ceremonial Participation, and Mental and Physical Health Among Rural and Urban Wixárika in Jalisco, Mexico.

Shattuck EC, McKinnon L, Herrera IR et al. · 2026 · American journal of human biology : the official journal of the Human Biology Council

Objectives Research in Western samples has repeatedly demonstrated a link between exposure to nature and natural stimuli and improved health. We sought to test these relationships in a sample of Indigenous Wixárika, whose traditional…

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Negative / Null Result ReportMedicine

Prognostic factors and outcome measures after BRAF-directed targeted therapy of unresectable metastatic BRAF<sup>V600E</sup> colorectal cancer: a study cohort-level analysis.

Colloca GA, Venturino A · 2026 · Investigational new drugs

BRAF V600E mutation in metastatic colorectal cancer (mCRC) is associated with a poor prognosis. BRAF V600E inhibitors (BRAFi) plus EGFR inhibitors + / - MEK inhibitors regimens prolonged overall survival (OS), but prognosis remains…

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Negative / Null Result ReportMedicine

The association of non-alcoholic fatty liver index, plasma metal levels, and genetic susceptibility using genome-wide type analysis.

Yu SH, Luo KH, Yang CC et al. · 2026 · Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

Background & aims This study aimed to explore the relationship between heavy metal exposure and the occurrence of non-alcoholic fatty liver disease (NAFLD), an area with conflicting existing research and unexplored genetic implications.…

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Negative / Null Result Report

Association of Sociodemographic Factors, Diabetes Mellitus, and Chronic Low Back Pain with Sarcopenia among Community-Dwelling Older Adults in West Jakarta, Indonesia

Widjaya CB, Kristian K, Handajani YS et al. · 2026 · Preprint

Abstract Background Sarcopenia is a geriatric syndrome characterized by progressive loss of skeletal muscle mass, strength, and physical performance, leading to disability and reduced quality of life. Several factors, including…

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Negative / Null Result ReportMedicine

Serial homicide offenders and the lunar cycle.

Salafranca Barreda D, González JA · 2026 · Chronobiology international

The purpose of this research is to establish whether there are factors that contribute to the predatory activation of serial homicide offenders (SHOs) in relation to the lunar cycles. In order to move the discussion away from the media…

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Negative / Null Result ReportOpen accessMedicine

Exploring the role of ankle torque fluctuations and intramuscular coherence in gait function among older adults.

Yaguchi-Horiuchi A, Tsuji T, Takeuchi H et al. · 2025 · Aging clinical and experimental research

Objective This study aimed to investigate the relationship between ankle joint function and walking performance in older adults by assessing qualitative ankle functions through torque fluctuation analysis and tibialis anterior (TA)…

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Negative / Null Result Report

The Evaluation of Inflammatory Biomarkers in Predicting the Severity and Steroid Responsiveness of Acute Graft versus Host Disease after Haplo- Identical Transplantation

Zakaria K, Khalaf MH, Soryal GB et al. · 2025 · Preprint

Abstract Background; Haematopoietic stem cell transplant (HSCT) is the transplant of stem cells usually derived from bone marrow, Peripheral blood, Umbilical cord, Matched sibling donor (HLA 6/6) , Or Haplo-Identical donor (HLA Matching…

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Negative / Null Result ReportMedicine

The Impact of Operative Timing on Postoperative Complications in Laparoscopic Appendectomy for Uncomplicated Acute Appendicitis: A Retrospective Cohort Study.

Bozkurt H, Taşkın M, Özcan C et al. · 2026 · Journal of laparoendoscopic & advanced surgical techniques. Part A

Background Acute appendicitis (AA) is one of the most common surgical conditions presenting as acute abdomen. Delaying appendectomy can increase the risk of perforation. However, patients admitted or treated at night have been found to…

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Failed Experiment ReportMedicine

Plate configuration in midshaft clavicle fractures: influence of working length, screw number, and plate length-a retrospective cohort study of 355 patients.

Hinkelmann MA, Schibler D, Frei F et al. · 2026 · European journal of orthopaedic surgery & traumatology : orthopedie traumatologie

INTRODUCTION: Midshaft clavicle fractures are commonly treated with plate fixation; however, the selected plate working length varies widely. Biomechanical principles suggest potential effects on fracture healing, but clinical evidence…

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Negative / Null Result ReportMedicine

Composite dietary antioxidant index and cardiovascular diseases and all-cause mortality in Iranian adults: a prospective cohort study.

Farhadnejad H, Mokhtari E, Dianati Z et al. · 2026 · Nutrition, metabolism, and cardiovascular diseases : NMCD

Background and aims Antioxidants are known to combat oxidative stress, a key factor in the development of cardiovascular diseases(CVDs) and mortality. In the current study, we aimed to prospectively investigate the relationship between the…

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Negative / Null Result ReportOpen accessMedicine

Is Demographic Concordance Between Lifestyle Coach and Participant Associated With Participant Retention and Weight Change in the National Diabetes Prevention Program Lifestyle Change Intervention?

Smart BP, Forte A, Jacobs J et al. · 2026 · Journal of diabetes research

Objective The goal of this study is to explore the association between racial/ethnic, sex, and age category concordance and participant retention and weight loss among participants enrolled in the National Diabetes Prevention Program…

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