21,287 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Sedghi A, Kaiser DPO, Arndt M et al. · 2026 · Annals of clinical and translational neurology
Objective Intravenous thrombolysis (IVT) before thrombectomy for ischemic stroke may alter clot structure and procedural performance. We investigated how IVT relates to thrombectomy metrics across stroke etiologies. Methods We performed a…
View details →Elham Mahdavi, Ghorbani Yekta B, Fereshteh Atabi · 2026 · Cellular and molecular biology (Noisy-le-Grand, France)
Rapid-eye movement (REM) sleep is a critical stage of sleep that plays a pivotal role in memory formation, consolidation, and mood regulation. While REM sleep deprivation (REM SD) has been shown to impair cognitive and affective functions,…
View details →Hsu G, Petticord DF, Slimon KF et al. · 2025 · Oikos
Prey capture by carnivorous plants is influenced by plant traits, environmental factors and interactions with animals. However, little is known about how interactions with heterospecific plant neighbors affect prey capture. Here, we…
View details →Azzopardi S, Garcin B, Mesrati F et al. · 2026 · Neurophysiologie clinique = Clinical neurophysiology
Background and objective In patients with functional neurological disorder (FND), transcranial magnetic stimulation (TMS) can be used for either diagnostic or therapeutic purpose. This study aimed to determine patients' expectations and…
View details →Rodriguez AK, Taylor TL, Fawver B et al. · 2026 · Psychology of sport and exercise
Individuals experiencing anxiety exhibit attentional biases towards unpleasant stimuli. Exercise is an anxiolytic intervention, evidenced by changes in attentional bias following physical activity. Many individuals experience 'anxiety…
View details →Amaravadi RK · 2022 · Autophagy
Macroautophagy/autophagy is a resistance mechanism to targeted therapy in BRAF mutant cancers. Preclinical evidence and clinical trial data demonstrate that hydroxychloroquine (HCQ) is an effective autophagy inhibitor at clinically…
View details →Okuizumi R, Maruyama S, Okamoto M et al. · 2026 · Journal of clinical biochemistry and nutrition
Coenzyme Q10 is a lipid-soluble antioxidant essential for the mitochondrial electron transport chain. Its concentration in the body decreases with age. The biosynthesis of coenzyme Q10 involves enzymes coq1 (PDSS1, PDSS2) through coq9,…
View details →Martin BI, Mirza SK, Ko H et al. · 2026 · The spine journal : official journal of the North American Spine Society
Background context Medicare's Transforming Episode Accountability Model (TEAM) holds hospitals accountable for 30-day postoperative complications across 18 categories of spinal fusion bundles, yet baseline differences in complication rates…
View details →Anijs RJS, Nguyen YN, Yanovska M et al. · 2025 · Thrombosis research
Background Colorectal cancer (CRC) patients are at increased risk of developing venous thromboembolism (VTE), leading to high morbidity and mortality. The exact mechanism remains unknown, which complicates risk prediction and treatment.…
View details →Yang S, Qin M, Wei J et al. · 2026 · Industrial Crops & Products.
Nicotinic acid (NIA) is known to function in heavy metal detoxification; however, the regulation and physiological significance of its endogenous secretion in metal tolerance remain unclear. In this study, NIA was identified as a…
View details →Jung J, Lutz KL, Dreager-Tougas KC et al. · 2025 · Journal of neurophysiology
Proctolin, an arthropod neuropeptide, is present in synaptic terminals innervating body wall muscles of Drosophila larvae. It acts as a cotransmitter with the excitatory neurotransmitter, l-glutamate (Glu). Previous work showed that…
View details →Vondrasek JD, Brown JE, Grosicki GJ et al. · 2026 · Journal of strength and conditioning research
Abstract Vondrasek, JD, Brown, JE, Grosicki, GJ, and Flatt, AA. Effects of short-duration cycling after resistance exercise on aortic stiffness and next-day recovery in strength-trained men. J Strength Cond Res 40(5): 536-544, 2026-We…
View details →Bessonova Y, Clark I, Sumida R et al. · 2025 · Preprint
Neuromodulators play a key role in determining how an organism processes and responds to sensory cues. Often, different neuromodulators act on the same set of neural circuits to produce diverging behavioral outcomes. In this study, we…
View details →Scherer JS, Wu W, Wetmore JB et al. · 2026 · Kidney360
Background Legalization of cannabis across several US states may increase its use by individuals on hemodialysis, particularly among those with chronic pain. Contemporary data on frequency or factors associated with cannabis use by this…
View details →Men X, Taylor ZL, Marshe VS et al. · 2026 · Canadian journal of psychiatry. Revue canadienne de psychiatrie
BackgroundVenlafaxine is commonly prescribed for older adults with depression, yet the relationship between venlafaxine-related exposure and treatment outcomes remains unclear. We aimed to assess the association of exposure to venlafaxine,…
View details →Littmann J, Steiner N, Cabrejo-Jones K et al. · 2026 · The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
Background A Moberg osteotomy is a dorsal closing wedge osteotomy of the base of the first proximal phalanx that is thought to augment the effect of cheilectomy by increasing dorsiflexion and ultimately improve patient outcomes in Hallux…
View details →Böhm M, Stegemann A, Wolnicka-Głubisz A et al. · 2026 · Aging and disease
Alpha-melanocyte-stimulating hormone (α-MSH) is a key endocrine mediator of photoprotection in the ultraviolet (UV)B-induced skin response. Its effects are mediated by the melanocortin-1 (MC1R) receptor and include increased eumelanin…
View details →Cabaret J, Guerrero Molina C, Martínez-Ortiz-de Montellano C et al. · 2026 · Pathogens (Basel, Switzerland)
Faecal egg counts (FECs) are used to assess the intensity of gastrointestinal nematode (GIN) infections in herbivores. FEC distribution is aggregated, meaning that approximately 20% of animals harbour 80% of infections. In times of…
View details →Santos de Oliveira N, Barbieri M, Moraes PA et al. · 2026 · Women & health
A prospective longitudinal study was conducted among 70 users of the etonogestrel contraceptive implant. World Health Organization Quality of Life (WHOQOL-BREF), Female Sexual Function Index (FSFI), and Birth Control Satisfaction…
View details →Yaqub M, Bonde N, Maity T et al. · 2026 · Preprint
Acinetobacter baumannii is a major cause of multidrug-resistant nosocomial infections, particularly ventilator-associated pneumonia, for which therapeutic options are increasingly limited. Colistin, a polymyxin antibiotic, is a drug of…
View details →Nie Y, Staley A, Hinz TK et al. · 2026 · Clinical lung cancer
Background Although ALK-positive non-small cell lung cancer (NSCLC) derives limited benefit from immune checkpoint inhibitors, PD-L1 expression is frequently elevated at diagnosis. The clinical relevance of PD-L1 expression for the…
View details →Bonilla AM, Garrido G, Consolini AE et al. · 2025 · Preprint
Gomphrena perennis L. possesses a rich phenolic profile and has demonstrated cardiovascular and anti-inflammatory activities; however, its neuropharmacological properties re-main unexplored. The behavioral effects, underlying mechanisms,…
View details →Marcotte-Chénard A, Sandilands RE, Teixeira AA et al. · 2026 · American journal of physiology. Cell physiology
Beta-hydroxybutyrate (BHB) exerts anti-inflammatory effects in cell and animal models, but translational work in humans remains limited. We investigated how exogenous ketone monoester (KME) ingestion in vivo and BHB treatment of human…
View details →Effinger D, Hirschberger S, Arntjen T et al. · 2026 · Nutrients
Background/Objectives : The ketogenic diet (KD) has been shown to exert beneficial effects on human immunity by enhancing cytotoxic T lymphocyte function through metabolic reprogramming. However, strict dietary restrictions limit adherence…
View details →Kobayashi A, Kawashima S, Kimura T et al. · 2026 · The journal of medical investigation : JMI
Whether the difference in video laryngoscope view affects the success of endotracheal intubation in beginners is unknown. In the current study, we aimed to investigate whether the revision of the monitor program in a Macintosh-type video…
View details →Gálvez-García G, Romero-Arias T, Barramuño-Medina M et al. · 2026 · Behavioural brain research
This study examined the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on inhibitory control during motor tasks of varying complexity. Motor task complexity was manipulated in a Simon task using two approaches: (1)…
View details →Bos MD, Ho CSL, Meyer NH et al. · 2026 · The Journal of surgical research
Introduction Epidemiological studies indicate that physical activity reduces cancer risk and mortality, while sedentary behavior exerts opposite effects. However, their impact on tumor metastasis remains unclear. This study investigated…
View details →Sogawa K, Funada M · 2026 · Toxicology letters
Cannabidiol (CBD) is a non-psychoactive cannabinoid with increasing global use, yet safety data during pregnancy remain limited. Preclinical studies suggest possible developmental neurotoxicity. Here, we examined the effects of CBD…
View details →Takata M, Nishikawa M, Hayashi H et al. · 2025 · Cureus
Background It remains unclear whether omecamtiv mecarbil, a cardiac myosin direct activator, enhances vascular smooth muscle myosin function at clinical and supra-clinical doses. Aims The current study evaluated the effect of omecamtiv…
View details →Day AS, Ballard TM, Benetti M et al. · 2026 · Journal of the Academy of Nutrition and Dietetics
Background The "gold standard" for successful blinding in controlled food-based dietary interventional trials includes a sham diet. Objective This study aimed to develop and evaluate a sham diet intended for use as a comparator in…
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