Negative / Null Result ReportMedicine
Zhou DD, Lord SJ, Lin FP et al. · 2026 · Lung cancer (Amsterdam, Netherlands)
Background In NSCLC, TP53 mutations are heterogeneous with varied effects on protein synthesis, function and clinical outcomes. We hypothesize that a refined classification of TP53 mutations, beyond binary categorization, could improve…
View details →Negative / Null Result ReportMedicine
Peckler GL, Adcock SJJ · 2025 · Research in Veterinary Science
Mastitis is a major concern in sheep farming. Detecting subclinical mastitis, which manifests without apparent signs, is particularly challenging. While somatic cell count (SCC) and the California Mastitis Test (CMT) are widely used in…
View details →Negative / Null Result ReportMedicine
Coşkun Yaş S, Üçöz Kocaşaban D, Güler S et al. · 2026 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Optic nerve sheath diameter (ONSD) measurement is a non-invasive marker of intracranial pressure. Its role in predicting post-thrombolytic intracranial hemorrhage in acute ischemic stroke patients remains unclear. This study aimed to…
View details →Negative / Null Result ReportMedicine
Kim J, Lee YY, Kim TJ et al. · 2026 · International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
Objective Sarcopenia is a known adverse prognostic factor in gastrointestinal cancers undergoing bowel resection; however, its prognostic relevance in epithelial ovarian cancer remains unclear. This study aimed to evaluate the prognostic…
View details →Negative / Null Result Report
Kuhlmann BG, Shakoor S, Schicker LA et al. · 2025 · Preprint
While it is well-established that sleep benefits episodic memory, most evidence is on younger adults. The current study examined sleep benefits in older adults and chose spatial source memory as a target measure for which a recent study in…
View details →Negative / Null Result ReportMedicine
Liang J, Pillai T, Chopra S et al. · 2025 · Aesthetic surgery journal
Background Utilization of glucagon-like peptide-1 receptor agonists (GLP-1ras) has increased dramatically in recent years. Although GLP-1ras appear safe to use overall, it remains unclear whether preoperative GLP-1ra use impacts body…
View details →Negative / Null Result ReportMedicine
Jourde HR, Ujevco A, Coffey EBJ · 2025 · NeuroImage
Slow oscillations and sleep spindles are neural events that both occur during non-rapid eye movement sleep and are implicated in sleep-dependent memory consolidation. Their temporal co-occurrence, or 'coupling', is thought to support…
View details →Negative / Null Result ReportMedicine
Mehari KR, Schuler KR, Haiflich A et al. · 2025 · Violence and victims
This study examined the implementation of a state law in the southern United States that required hospitals to report gunshot wounds (GSWs) to law enforcement by exploring changes in the proportion of reported GSW cases in a level 1 trauma…
View details →Negative / Null Result Report
Gago T, Sargisson RJ, Milfont TL · 2025 · Preprint
Despite being an important mental health consequence of climate change, climate anxiety assessment has been fragmented. Reviews of measures of climate anxiety raise concerns about content and convergent validity. We aimed to select the…
View details →Negative / Null Result ReportMedicine
Hernández L, Williamson TM, Campbell T et al. · 2025 · The Canadian journal of cardiology
Background Cardiac rehabilitation (CR) participation improves depressive and anxious symptoms post-coronary catheterization, yet it is unclear to what extent improvements are clinically significant. This study characterized the proportion…
View details →Negative / Null Result Report
Bagchi A, Sengupta S, Ghosh P et al. · 2026 · Preprint
Abstract Background Rheumatoid arthritis (RA) is associated with inflammation, oxidative stress along with infiltration of immune cells (~ 90% neutrophils) into inflamed joints. Neutrophils have demonstrated the ability to…
View details →Negative / Null Result ReportMedicine
Ivanov YV, Kartashov AV, Ivanova AI et al. · 2026 · Functional plant biology : FPB
Global climate change is accompanied by an increase in the frequency and severity of droughts, which negatively impact plant growth. One of the protective mechanisms that allows plants to withstand the negative drought effects is the…
View details →Negative / Null Result Report
Kalluri VS, Kalluri R · 2026 · Preprint
Tumstatin and Endostatin are endogenous extracellular matrix-derived inhibitors of angiogenesis generated from the non-collagenous domains of type IV and type XVIII collagens, respectively. Although both molecules suppress angiogenesis and…
View details →Negative / Null Result Report
Mbaluto CM, Martinez-Goni XS, Tripathi A et al. · 2026 · Preprint
Cereal grafting using embryonic tissues has recently become technically feasible; however, the physiological consequences of cereal grafting remain uncharacterized. We systematically evaluate photosynthetic performance and stomatal…
View details →Negative / Null Result Report
Segura-Chama P, Hernández VS, Zhang L · 2026 · Preprint
Adrenal chromaffin cells are key effectors of the sympathoadrenal response and play a central role in physiological adaptation to stress. While acetylcholine and pituitary ad-enylate cyclase-activating polypeptide (PACAP) are recognized…
View details →Negative / Null Result Report
Chan A, Freschi L, de-Pinna GFAM · 2026 · Preprint
Abstract Leaf sheaths in monocotyledons may be open or closed, yet the developmental regulation of sheath margins remains unclear in Commelinaceae, a family with closed sheaths. This study investigated the morphogenesis of leaf sheaths in…
View details →Negative / Null Result ReportMedicine
Lanham BS, Morris RL · 2026 · Marine environmental research
The strength of biotic stressors (i.e., predation) can determine the success of shellfish reef restoration projects. In recruitment limited systems where seeding is a common restoration strategy, ensuring the survival of seeded individuals…
View details →Negative / Null Result ReportMedicine
Turner KM, Svegborn A, Robbins TW · 2026 · Psychopharmacology
Rationale Recent research on habits and skills has produced a wave of new theories regarding the shift in control from medial to lateral regions of the dorsal striatum, and how these regions are implicated in the selected and executed of…
View details →Failed Experiment ReportMedicine
Strandberg E, Vikmoen O, Svindland KV et al. · 2026 · European journal of sport science
To evaluate whether strength training during chemotherapy alters (1) serum cytokines and (2) skeletal muscle autophagy- and heat-shock-related proteins in women with breast cancer. Exploratory analyses assessed associations between changes…
View details →Failed Experiment Report
Fortugno P, Foti F, Caparra P et al. · 2026 · Preprint
Bergamot-derived products have gained increasing interest as dietary supplements in small animal nutrition, due to their potential to improve meat quality, and provide functional bioactive compounds. This paper investigated the effects of…
View details →Failed Experiment ReportMedicine
García-Mendoza A, González-Hernández M, Vega-Manriquez DX et al. · 2026 · Veterinary sciences
This study investigated the associations among dam lactation number, passive immunity transfer, internal parasite burden, and weaning performance in female calves. Early consumption of high-quality colostrum is critical for effective…
View details →Negative / Null Result Report
Uenishi R, Kawata R, Manabe T et al. · 2026 · Preprint
Neuroinflammation is a central driver of tauopathy, yet the precise chemokines that orchestrate the inflammatory microenvironment remain elusive. Here, we report C-X-C motif chemokine ligand 10 (CXCL10) is markedly upregulated in the…
View details →Negative / Null Result Report
Dachille GP, Zuanna AD, Paiella M et al. · 2026 · Preprint
Abstract We quantify how the employment expansion accompanying Italy’s post-pandemic recovery mitigated the distributional consequences of the contemporaneous surge in prices, which disproportionately affected households at the bottom of…
View details →Negative / Null Result Report
Cárdenas SA · 2026 · Preprint
Objective(s): Strategic overcharging involves threatening disproportionately harsh punishment to widen the differential between the potential sentence if convicted at trial (PTS) and the plea sentence. Though larger discounts increase plea…
View details →Negative / Null Result ReportMedicine
Enciso-Pablo Ó, Sierra-Ramírez F, Sotres-Bayon F · 2026 · Psychopharmacology
Rationale Benzodiazepines are widely used to treat anxiety; however, their influence on defensive behavior when threats compete with rewards remains unclear. Objectives Here, we tested the effects of diazepam on reactive avoidance (no…
View details →Negative / Null Result Report
Ben-Chetrit E, Zilberstein Z, Levin PD · 2026 · Preprint
Abstract Background Obtaining blood cultures at IV insertion is common practice, but is probably associated with greater contamination. Whether use of first-aliquot-diversion (diversion) reduces contamination in this context is not clear.…
View details →Methods Dead-EndMedicine
Jiang Y, Zanganeh M, Waugh N et al. · 2026 · Gastrointestinal endoscopy
Background and aims Endoscopy units are increasingly being encouraged to consider replacing multiple-use (MU) endoscopes with single-use (SU) endoscopes, largely due to reduction in cross-infection. While evidence suggests comparable…
View details →Negative / Null Result Report
DiLeone R, Trinko JR, Atangana E et al. · 2026 · Preprint
Binge eating disorder (BED) is characterized by episodic overconsumption of palatable food and involves dysregulated motivational and arousal processes. The orexin (hypocretin) system, through its widespread projections to mesolimbic…
View details →Negative / Null Result ReportMedicine
Plouhinec L, Maresca M, Saget J et al. · 2026 · Applied microbiology and biotechnology
As demand for sustainable and welfare-conscious food production increases, reducing the environmental and health impacts of animal feed has become a key challenge. Soybean meal (SBM) is widely used in poultry diets for its high protein…
View details →Negative / Null Result Report
Pearson AL, Tomaszewska MA, Brown CD et al. · 2026 · Preprint
Abstract Exposure to heat in urban settings is a significant and growing public health concern. Yet, few studies have longitudinally measured everyday heat exposure using GPS-derived activity space data, paired with fine resolution…
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