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Browse the failure-mode index

21,173 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportComputer Science

Serf and turf

Gang Wang, Christo Wilson, Xiaohan Zhao et al. · 2012

Popular Internet services in recent years have shown that remarkable things can be achieved by harnessing the power of the masses using crowd-sourcing systems. However, crowd-sourcing systems can also pose a real challenge to existing…

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Negative / Null Result ReportDecision Sciences

An empirical examination of customers’ adoption of m-banking in India

Madhurima Deb, Ewuuk Lomo‐David · 2014 · Marketing Intelligence & Planning

Purpose – The purpose of this paper is to identify factors impacting the adoption of m-banking. Design/methodology/approach – To attain the above objective a conceptual model was developed based on Technology Acceptance Model (TAM) and…

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A randomized, double‐blind, placebo‐controlled, multicenter trial: The MASTERS trial

R. Grace Walton, Cory M. Dungan, Douglas E. Long et al. · 2019 · Aging Cell

Progressive resistance exercise training (PRT) is the most effective known intervention for combating aging skeletal muscle atrophy. However, the hypertrophic response to PRT is variable, and this may be due to muscle inflammation susceptibility. Metformin reduces inflammation, so we hypothesized that metformin would augment the muscle response to PRT in healthy women and men aged 65 and older. In a randomized, double-blind trial, participants received 1,700 mg/day metformin (N = 46) or placebo (N = 48) throughout the study, and all subjects performed 14 weeks of supervised PRT. Although respo

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Negative / Null Result ReportBusiness, Management and Accounting

The effect of the Rana Plaza disaster on shareholder wealth of retailers: Implications for sourcing strategies and supply chain governance⋆

Brian W. Jacobs, Vinod R. Singhal · 2017 · Journal of Operations Management

Abstract Supply chain and reputational risks are often assumed to motivate firms to source production in developed, high‐cost countries rather than developing, low‐cost countries. To examine this assumption, we provide evidence from the…

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Negative / Null Result ReportOpen accessPsychology

Social status predicts wound healing in wild baboons

Elizabeth A. Archie, Jeanne Altmann, Susan C. Alberts · 2012 · Proceedings of the National Academy of Sciences

Social status can have striking effects on health in humans and other animals, but the causes often are unknown. In male vertebrates, status-related differences in health may be influenced by correlates of male social status that suppress…

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Negative / Null Result ReportOpen accessEarth and Planetary Sciences

Evaluation of 23 gridded precipitation datasets across West Africa

Frédéric Satgé, Dimitri Defrance, Benjamin Sultan et al. · 2019 · Journal of Hydrology

This study aims reporting on 23 gridded precipitation datasets (P-datasets) reliability across West Africa through direct comparisons with rain gauges measurement at the daily and monthly time scales over a 4 years period (2000–2003). All…

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Negative / Null Result ReportOpen accessMedicine

Alpha‐synuclein mRNA expression in oligodendrocytes in MSA

Yasmine T. Asi, Julie E. Simpson, Paul R. Heath et al. · 2014 · Glia

Multiple system atrophy (MSA) is a progressive neurodegenerative disease presenting clinically with parkinsonian, cerebellar, and autonomic features. α-Synuclein (αsyn), encoded by the gene SNCA, is the main constituent of glial cytoplasmic inclusion (GCI) found in oligodendrocytes in MSA, but the methods of its accumulation have not been established. The aim of this study is to investigate alterations in regional and cellular SNCA mRNA expression in MSA as a possible substrate for GCI formation. Quantitative reverse transcription polymerase chain reaction (qPCR) was performed on postmortem br

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Negative / Null Result ReportOpen accessSocial Sciences

Inputs, Incentives, and Complementarities in Education: Experimental Evidence from Tanzania*

Isaac Mbiti, Karthik Muralidharan, Mauricio Romero et al. · 2019 · The Quarterly Journal of Economics

Abstract We present results from a large-scale randomized experiment across 350 schools in Tanzania that studied the impact of providing schools with (i) unconditional grants, (ii) teacher incentives based on student performance, and (iii)…

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Polygenic risk of Alzheimer disease is associated with early- and late-life processes

Elizabeth C. Mormino, Reisa A. Sperling, Avram J. Holmes et al. · 2016 · Neurology

OBJECTIVE: To examine associations between aggregate genetic risk and Alzheimer disease (AD) markers in stages preceding the clinical symptoms of dementia using data from 2 large observational cohort studies. METHODS: We computed polygenic…

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Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology

Methylation at 5HTT Mediates the Impact of Child Sex Abuse on Women's Antisocial Behavior: An Examination of the Iowa Adoptee Sample

Steven R. H. Beach, Gene H. Brody, Alexandre A. Todorov et al. · 2010 · Psychosomatic Medicine

OBJECTIVE: To examine epigenetic processes linking childhood sex abuse to symptoms of antisocial personality disorder (ASPD) in adulthood and to investigate the possibility that the link between childhood sex abuse and deoxyribonucleic…

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Negative / Null Result ReportOpen accessMedicine

The Next Generation of Sepsis Clinical Trial Designs

Steven M. Opal, R. Phillip Dellinger, Jean‐Louis Vincent et al. · 2014 · Critical Care Medicine

OBJECTIVE: The developmental pipeline for novel therapeutics to treat sepsis has diminished to a trickle compared to previous years of sepsis research. While enormous strides have been made in understanding the basic molecular mechanisms…

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Negative / Null Result ReportOpen accessMedicine

Mortality Attributable to 9 Common Infections: Significant Effect of Influenza A, Respiratory Syncytial Virus, Influenza B, Norovirus, and Parainfluenza in Elderly Persons

Liselotte van Asten, Cees van den Wijngaard, Wilfrid van Pelt et al. · 2012 · The Journal of Infectious Diseases

BACKGROUND: Because there may be substantial hidden mortality caused by common seasonal pathogens, we estimated the number of deaths in elderly persons attributable to viruses and bacteria for which robust weekly laboratory surveillance…

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Negative / Null Result ReportOpen accessEarth and Planetary Sciences

Multi-species collapses at the warm edge of a warming sea

Gil Rilov · 2016 · Scientific Reports

Even during the current biodiversity crisis, reports on population collapses of highly abundant, non-harvested marine species were rare until very recently. This is starting to change, especially at the warm edge of species' distributions where populations are more vulnerable to stress. The Levant basin is the southeastern edge of distribution of most Mediterranean species. Coastal water conditions are naturally extreme, and are fast warming, making it a potential hotspot for species collapses. Using multiple data sources, I found strong evidence for major, sustained, population collapses of t

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Negative / Null Result ReportOpen accessSocial Sciences

Faith after an Earthquake: A Longitudinal Study of Religion and Perceived Health before and after the 2011 Christchurch New Zealand Earthquake

Chris G. Sibley, Joseph Bulbulia · 2012 · PLoS ONE

On 22 February 2011, Christchurch New Zealand (population 367,700) experienced a devastating earthquake, causing extensive damage and killing one hundred and eighty-five people. The earthquake and aftershocks occurred between the 2009 and 2011 waves of a longitudinal probability sample conducted in New Zealand, enabling us to examine how a natural disaster of this magnitude affected deeply held commitments and global ratings of personal health, depending on earthquake exposure. We first investigated whether the earthquake-affected were more likely to believe in God. Consistent with the Religio

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Negative / Null Result ReportOpen accessMedicine

Vitamin D, Calcium, or Combined Supplementation for the Primary Prevention of Fractures in Community-Dwelling Adults

US Preventive Services Task Force, David C. Grossman, Susan J. Curry et al. · 2018 · JAMA

Importance: Because of the aging population, osteoporotic fractures are an increasingly important cause of morbidity and mortality in the United States. Approximately 2 million osteoporotic fractures occurred in the United States in 2005,…

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Negative / Null Result ReportEconomics, Econometrics and Finance

Changing Business Dynamism and Productivity: Shocks versus Responsiveness

Ryan A. Decker, John Haltiwanger, Ron S. Jarmin et al. · 2020 · American Economic Review

The pace of job reallocation has declined in the United States in recent decades. We draw insight from canonical models of business dynamics in which reallocation can decline due to (i ) lower dis persion of idiosyncratic shocks faced by…

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Negative / Null Result ReportEconomics, Econometrics and Finance

Long-Run Health Impacts of Income Shocks: Wine and Phylloxera in Nineteenth-Century France

Abhijit Banerjee, Esther Duflo, Gilles Postel‐Vinay et al. · 2010 · The Review of Economics and Statistics

Between 1863 and 1890, phylloxera destroyed 40% of French vineyards. Using the regional variation in the timing of this shock, we identify and examine the effects on adult height, health, and life expectancy of children born in the years…

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Negative / Null Result ReportOpen accessPhysics and Astronomy

Scalable detection of statistically significant communities and hierarchies, using message passing for modularity

Pan Zhang, Cristopher Moore · 2014 · Proceedings of the National Academy of Sciences

Modularity is a popular measure of community structure. However, maximizing the modularity can lead to many competing partitions, with almost the same modularity, that are poorly correlated with each other. It can also produce illusory…

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Negative / Null Result ReportOpen accessMedicine

What Comes First? Multitissue Involvement Leading to Radiographic Osteoarthritis: Magnetic Resonance Imaging–Based Trajectory Analysis Over Four Years in the Osteoarthritis Initiative

Frank W. Roemer, C. Kent Kwoh, Michael J. Hannon et al. · 2015 · Arthritis & Rheumatology

OBJECTIVE: To assess whether the presence of structural osteoarthritis (OA) features over as many as 4 years prior to incident radiographic OA increases the risk of radiographic OA in a nested, case-control design. METHODS: We studied 355…

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Negative / Null Result ReportNeuroscience

The Animacy Continuum in the Human Ventral Vision Pathway

Long Sha, James V. Haxby, Hervé Abdi et al. · 2014 · Journal of Cognitive Neuroscience

Major theories for explaining the organization of semantic memory in the human brain are premised on the often-observed dichotomous dissociation between living and nonliving objects. Evidence from neuroimaging has been interpreted to…

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Genome-Wide Association Study (GWAS) for Growth Rate and Age at Sexual Maturation in Atlantic Salmon (Salmo salar)

Alejandro P. Gutiérrez, José M. Yáñez, Steve Fukui et al. · 2015 · PLoS ONE

Early sexual maturation is considered a serious drawback for Atlantic salmon aquaculture as it retards growth, increases production times and affects flesh quality. Although both growth and sexual maturation are thought to be complex processes controlled by several genetic and environmental factors, selection for these traits has been continuously accomplished since the beginning of Atlantic salmon selective breeding programs. In this genome-wide association study (GWAS) we used a 6.5K single-nucleotide polymorphism (SNP) array to genotype ∼ 480 individuals from the Cermaq Canada broodstock pr

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Negative / Null Result ReportBusiness, Management and Accounting

Determinants of Disclosure Noncompliance and the Effect of the SEC Review: Evidence from the 2006 Mandated Compensation Disclosure Regulations

John R. Robinson, Yanfeng Xue, Yong Yu · 2011 · The Accounting Review

ABSTRACT We investigate the economic forces that influence noncompliance with mandatory compensation disclosures and the effect of a subsequent focused enforcement action. We utilize SEC evaluations of compensation disclosures mandated by…

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Negative / Null Result ReportOpen accessBusiness, Management and Accounting

An examination of e-HRM as a means to increase the value of the HR function

Emma Parry · 2011 · The International Journal of Human Resource Management

This article examines the potential use of e-human resource management (e-HRM) as a means to increase the value of the human resources (HR) function, within the framework of the resource-based view. Past research has suggested that e-HRM…

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Negative / Null Result ReportOpen accessMedicine

A Randomized Trial of Nighttime Physician Staffing in an Intensive Care Unit

Meeta Prasad Kerlin, Dylan S. Small, Elizabeth Cooney et al. · 2013 · New England Journal of Medicine

BACKGROUND: Increasing numbers of intensive care units (ICUs) are adopting the practice of nighttime intensivist staffing despite the lack of experimental evidence of its effectiveness. METHODS: We conducted a 1-year randomized trial in an…

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Negative / Null Result ReportComputer Science

Toward better horizontal integration among IoT services

Ala Al‐Fuqaha, Abdallah Khreishah, Mohsen Guizani et al. · 2015 · IEEE Communications Magazine

Several divergent application protocols have been proposed for Internet of Things (IoT) solutions including CoAP, REST, XMPP, AMQP, MQTT, DDS, and others. Each protocol focuses on a specific aspect of IoT communications. The lack of a…

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Negative / Null Result ReportOpen accessNeuroscience

Stimulus-Specific Adaptation in Auditory Cortex Is an NMDA-Independent Process Distinct from the Sensory Novelty Encoded by the Mismatch Negativity

Brandon J. Farley, Michael C. Quirk, James Doherty et al. · 2010 · Journal of Neuroscience

The significance of the mismatch negativity (MMN), an event-related potential measured in humans which indexes novelty in the auditory environment, has motivated a search for a cellular correlate of this process. A leading candidate is…

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Blood Pressure and Hypertension Are Associated With 7 Loci in the Japanese Population

Fumihiko Takeuchi, Masato Isono, Tomohiro Katsuya et al. · 2010 · Circulation

BACKGROUND: Two consortium-based genome-wide association studies have recently identified robust and significant associations of common variants with systolic and diastolic blood pressures in populations of European descent, warranting…

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