Polygenic risk of Alzheimer disease is associated with early- and late-life processes
Elizabeth C. Mormino; Reisa A. Sperling; Avram J. Holmes; Randy L. Buckner; Philip L. De Jager; Jordan W. Smoller; Mert R. Sabuncu; For the Alzheimer's Disease Neuroimaging Initiative · 2016 · Neurology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
OBJECTIVE: To examine associations between aggregate genetic risk and Alzheimer disease (AD) markers in stages preceding the clinical symptoms of dementia using data from 2 large observational cohort studies. METHODS: We computed polygenic…
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Metadata source: OpenAlex · DOI 10.1212/wnl.0000000000002922