Negative / Null Result ReportOpen accessMedicine· cited by 196

Alpha‐synuclein mRNA expression in oligodendrocytes in MSA

Yasmine T. Asi; Julie E. Simpson; Paul R. Heath; Stephen B. Wharton; Andrew J. Lees; Tamás Révész; Henry Houlden; Janice L. Holton · 2014 · Glia

WASTE classifies this as Negative / Null Result Report · AI classification, approximate

The study found no significant effect — useful as a negative control or null benchmark for your own design.

Abstract

Multiple system atrophy (MSA) is a progressive neurodegenerative disease presenting clinically with parkinsonian, cerebellar, and autonomic features. α-Synuclein (αsyn), encoded by the gene SNCA, is the main constituent of glial cytoplasmic inclusion (GCI) found in oligodendrocytes in MSA, but the methods of its accumulation have not been established. The aim of this study is to investigate alterations in regional and cellular SNCA mRNA expression in MSA as a possible substrate for GCI formation. Quantitative reverse transcription polymerase chain reaction (qPCR) was performed on postmortem br

Abstract by Yasmine T. Asi; Julie E. Simpson; Paul R. Heath; Stephen B. Wharton; Andrew J. Lees; Tamás Révész; Henry Houlden; Janice L. Holton, Glia (2014) — licensed CC BY 4.0.

Read the full paper (open access)