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WASTE Journal

Browse the failure-mode index

21,277 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Differential impact of cumulative cerebral small-vessel disease burden on ischemic versus hemorrhagic stroke recurrence in hemorrhage-prone patients.

Park JH, Kwon SU · 2026 · Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Background Total cerebral small-vessel disease (cSVD) score is a well-established predictor of vascular risks. However, the specific type of recurrent stroke associated with cSVD scores remains unclear in hemorrhage-prone patients-those…

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Negative / Null Result ReportMedicine

Efficacy of Watercress (<i>Nasturtium officinale</i> R.Br.) Consumption on Blood Pressure, Oxidative Stress Biomarkers, and Estimated Cardiovascular Risk in Thai Middle-Aged Adults: A Randomized Placebo-Controlled Pilot Study.

Kijkuokool P, Rerkasem K, Fakfum P et al. · 2026 · Antioxidants (Basel, Switzerland)

Watercress ( Nasturtium officinale R.Br.) is a cruciferous vegetable rich in bioactive compounds that may improve cardiovascular disease (CVD) risk factors. However, clinical evidence regarding its direct impact on CVD risk remains…

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Negative / Null Result ReportMedicine

Serum ceramides predict all-cause and cardiovascular mortality in Chinese incident hemodialysis patients: a retrospective cohort study.

Zhang S, Wu YL, Li ZY et al. · 2026 · Kidney research and clinical practice

Background This study explored serum ceramide (Cer) levels' association with all-cause and cardiovascular disease (CVD) mortality in Chinese incident hemodialysis (HD) patients. Methods This retrospective cohort study included 253 adults…

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Negative / Null Result ReportMedicine

Unilateral posterior vertebral column resection versus bilateral approach for post-traumatic thoracic angular kyphosis: a propensity-matched non-inferiority study.

Ghobashy MK, AbdelFatah MA, Youssef ME et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Purpose Posterior vertebral column resection (PVCR) for severe post-traumatic thoracic angular kyphosis is effective but carries high morbidity. This study compares unilateral PVCR (UPVCR) with traditional bilateral PVCR (BPVCR),…

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Negative / Null Result Report

Theta Dual-Brain Stimulation of rTPJ Shapes Joint Agency

Kurihara Y, Tsuchiya A, Dumas G et al. · 2026 · Preprint

Summary Joint agency, the shared feeling of “we are doing this together”, has been linked to inter-brain synchrony, but its causal role in shaping this experience remains unclear. We applied dual transcranial alternating current…

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Negative / Null Result ReportMedicine

Face-to-face vs. telerehabilitation for thoracic hyperkyphosis in children- A randomized controlled pilot study.

Gözener Canbülbül S, Canbülbül B, Özcan Şİ et al. · 2026 · Journal of pediatric rehabilitation medicine

PurposeThis pilot study aimed to compare the effects of face-to-face and telerehabilitation approaches on thoracic hyperkyphosis, back extensor muscle strength, and discomfort in children.MethodsA randomized clinical trial was conducted in…

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Negative / Null Result ReportMedicine

The John Charnley Award: A Randomized Controlled Trial of Dual Mobility and Single Bearings for Patients at High Risk of Dislocation Following Primary Total Hip Arthroplasty.

Potluri AS, Yadav AS, Weintraub MT et al. · 2026 · The Journal of arthroplasty

Introduction This multicenter randomized controlled trial (RCT) sought to determine if dual-mobility bearings (DM) reduce dislocations in patients at high-risk for instability undergoing primary total hip arthroplasty (THA) compared to…

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Negative / Null Result ReportMedicine

Factors Affecting the Quantitative Value of the Pivot Shift Test Using a Navigation System in Anterior Cruciate Ligament Injured Knees.

Nakamae A, Nekomoto A, Nakata K et al. · 2026 · The journal of knee surgery

Abstract This study aimed to identify factors associated with greater quantitative pivot shift in anterior cruciate ligament (ACL)-injured knees by quantitatively assessing the pivot shift under anesthesia using a navigation system prior…

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Negative / Null Result ReportMedicine

Evaluation of the Effect of Different Drilling Systems on Trabecular Bone Microarchitecture During Implant Cavity Preparation Using CBCT: Ex Vivo Study.

Cakir M, Buyuk C, Kan B · 2026 · The International journal of oral & maxillofacial implants

Purpose Achieving optimal primary stability is critical for dental implant success, particularly in low-density bone regions such as the posterior maxilla. Conventional high-speed drilling with irrigation may remove vital bone fragments…

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Negative / Null Result ReportOpen accessMedicine

Dosimetric Impact of Artificial Intelligence (AI)-Based Autocontouring Software, OncoStudio, in High-Risk Prostate Cancer Treatment Planning: A Three-Group Comparative Study on the Slice Ranges of Seminal Vesicles.

Kawaguchi M, Hoshina M, Sugahara S et al. · 2026 · Cureus

Objective This pilot study investigated the dosimetric impact of artificial intelligence (AI)-generated seminal vesicle (SV) autocontouring (AC) compared with manual contouring (MC) in high-risk prostate cancer volumetric-modulated arc…

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Negative / Null Result ReportMedicine

Real-World Outcomes of Total Neoadjuvant Therapy Versus Standard Neoadjuvant Chemoradiotherapy in Stage II-III Locally Advanced Rectal Cancer: A Comparative Cohort Study.

Erken AA, Dincer ST · 2026 · Asia-Pacific journal of clinical oncology

Aim Total neoadjuvant therapy has been adopted to improve systemic disease control in locally advanced rectal cancer, yet long-term real-world outcomes, particularly in non-Western populations, remain incompletely defined. We compared…

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Negative / Null Result ReportMedicine

Inflammatory Biomarkers and Their Associations with Arrhythmic Burden Following SGLT2-I Treatment in Chronic Heart Failure-A Subanalysis of the ERASe Trial.

Benedikt M, Herrmann M, Aziz F et al. · 2026 · Journal of clinical medicine

Background : Sodium glucose-linked transport 2 inhibitors (SGLT2-Is) are well known to exert beneficial effects in chronic heart failure (CHF) independent of left ventricular ejection fraction (LVEF). As inflammation plays a key role in…

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Negative / Null Result ReportOpen accessMedicine

Two versus three cannulated screws in pediatric Delbet type II femoral neck fractures: a retrospective comparative study.

Erdoğan F, Cengiz T, Şimşek ŞA et al. · 2026 · Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES

Background Pediatric femoral neck fractures are rare but carry a high risk of complications such as avascular necrosis (AVN), premature physeal closure, and coxa vara. Although stable internal fixation is essential, the optimal number of…

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Negative / Null Result ReportMedicine

A randomized trial of carbon-dioxide flushing to reduce vascular brain injury in patients undergoing TAVI.

Khawaja SA, Hanna L, Singh A et al. · 2026 · EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

Background Stroke remains a significant concern in patients undergoing Transcatheter Aortic Valve Implantation (TAVI). Despite advances in TAVI technology and techniques, rates have remained unchanged, with trials of Cerebral embolic…

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Negative / Null Result ReportMedicine

FLAMSA versus FLAG-IDA as salvage therapy in adults with relapsed/refractory acute myeloid leukemia and acute lymphoblastic leukemia: A single-center real-world retrospective study.

Savaş EM, Bozkurt HH, Kemer NI et al. · 2026 · Leukemia research

Management of relapsed or refractory acute leukemia remains challenging, as allogeneic transplantation is the only curative option. Although targeted therapies are increasingly incorporated as bridge-to-transplant strategies in both AML…

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Negative / Null Result ReportMedicine

Effects of hydroxychloroquine sulfate combined with aspirin and enoxaparin sodium therapy on perinatal outcomes in patients with undifferentiated connective tissue disease-related recurrent miscarriage: a retrospective clinical study.

Pei LC, Wang T, Guo YJ et al. · 2026 · BMC pregnancy and childbirth

Background To evaluate the association between triple therapy (hydroxychloroquine sulfate, aspirin, and enoxaparin sodium) and pregnancy outcomes in patients with undifferentiated connective tissue disease (UCTD)-related recurrent…

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Negative / Null Result ReportMedicine

Real-world insights on switching aflibercept dosage for enhanced outcomes in age-related macular degeneration (RISE-AMD): Safety data.

Karunainathan MG, Lee C, Zohalinejad KD et al. · 2026 · Acta ophthalmologica

Purpose To evaluate real-world safety experience with aflibercept 8 mg in a large case series of patients with neovascular age-related macular degeneration (nAMD). Methods Due to a high proportion of patients on short treatment intervals,…

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Negative / Null Result ReportMedicine

Closing gaps in urban trauma systems: Outcomes of an inner-city community emergency department multidisciplinary trauma protocol.

London KS, Cherney A, Neupane S et al. · 2026 · The American journal of emergency medicine

Background Non-trauma center (NTC) emergency departments (EDs) play regular but underappreciated roles in the management of severely injured patients, yet many lack formal protocols to guide care. We describe the implementation and…

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Negative / Null Result ReportMedicine

Preoperative computed tomography findings of chest wall or mediastinal invasion in pulmonary metastases among children, adolescents, and young adults.

Shirane K, Kitagawa N, Morishima R et al. · 2026 · Journal of pediatric surgery

Background Pulmonary metastasectomy can improve the survival of children with pulmonary metastases from solid tumors. However, preoperative imaging often suggests chest wall and/or mediastinal invasion, raising concerns about…

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Negative / Null Result ReportOpen accessMedicine

Investigating the lasting effects of SARS-CoV-2 infection and the lung microbiome: no persistent microbial alterations in recovered COVID-19 patients with persistent radiological or respiratory abnormalities.

Teng NMY, Vijayakumar B, Smith DJF et al. · 2026 · Access microbiology

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was a global pandemic where infected individuals experienced mild or severe disease. Unfortunately, some patients who experienced severe disease also had lasting abnormalities.…

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