Acute Effects of Myeloperoxidase Inhibition on Exercise Hemodynamics in Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial.
Popovic D; Reddy YNV; Omar M; Omote K; Melenovsky V; Burkhoff D; Borlaug BA · 2025 · Mayo Clinic proceedings
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Objective Myeloperoxidase (MPO) is a heme peroxidase that scavenges nitric oxide and contributes to microvascular dysfunction. Patients with heart failure and preserved ejection fraction (HFpEF) have microvascular dysfunction that leads to…
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Metadata source: Europe PMC · DOI 10.1016/j.mayocp.2025.02.022