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Browse the failure-mode index

21,710 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Factors Affecting Country Differences in the Incidence of Type 2 Diabetes Mellitus Based on the Global Burden of Disease Data 2021: A Multilevel Longitudinal Ecological Study.

Jaafari Z, Hassanzadeh J, Sayadi M et al. · 2026 · Health science reports

Background and aims The variation in the incidence of type 2 diabetes mellitus (T2DM) in different countries is associated with various factors. This study aimed to examine the factors linked to the difference in the incidence of T2DM…

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Negative / Null Result ReportMedicine

Addressing Biases in Analysis of Time of Infusion: NCI/SWOG Trial S1404 Among Participants With High-Risk Resectable Melanoma Who Received Adjuvant Anti-PD-1 Therapy.

Othus M, Truong TG, Sharon E et al. · 2026 · JCO oncology practice

Purpose Multiple reports have suggested that receiving immunotherapy infusions earlier in the day is associated with improved outcomes, including longer overall survival (OS) and lower toxicity rates. However, the definition of early…

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Negative / Null Result ReportMedicine

The association between mode of delivery and severe intraventricular hemorrhage in very preterm infants.

Keel E, Kalimeris S, Adams M et al. · 2026 · The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

Background Infants born before 32 weeks of gestation are at high risk of developing intraventricular hemorrhage (IVH), which is associated with significant mortality and morbidity as well as long-term neurodevelopmental impairment. There…

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Negative / Null Result ReportOpen accessMedicine

Effectiveness of Community-Based Breast Cancer Screening Using Full-Field Digital Mammography With Digital Breast Tomosynthesis in an Urban Population in Central India: An Observational Study.

Pande S, Dakhore S, Arora D et al. · 2026 · Cureus

Background Breast cancer is the most common malignancy among women worldwide and remains a leading cause of cancer-related mortality. In India, delayed presentation and limited access to organised screening programmes contribute to poorer…

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Negative / Null Result ReportOpen accessMedicine

Targeting Human Epidermal Growth Factor Receptor 2 in Bladder Cancer: Evaluating Its Role as a More Robust Clinicopathological Biomarker Compared to Programmed Death Ligand 1 Expression.

Mittal A, Malhotra K, Panwar V et al. · 2026 · Urology research & practice

Objective: This retrospective cross-sectional analytical study evaluated the clinicopathological associations of programmed death ligand 1 (PD-L1) and human epidermal growth factor receptor 2 (HER2/neu) expression in 250 patients with…

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Negative / Null Result ReportOpen accessMedicine

Correlation between symptom distress and quality of life in patients with Chronic Kidney Disease Stage 5 undergoing hemodialysis in China: a multi-center cross-sectional study.

Qiao X, Wang Y, Tian Z et al. · 2026 · Frontiers in psychiatry

Aim To explore the symptom distress and quality of life status of patients with Chronic Kidney Disease (CKD) Stage 5 undergoing hemodialysis in China, and their correlation. Methods The Dialysis Symptom Index (DSI) and the Kidney Disease…

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Negative / Null Result ReportOpen accessMedicine

Creatine Supplementation Dose and Duration Are Not Associated with Increased Side Effects: A Structured Review and Study-Level Dose-Response Analysis of Randomized Controlled Trials.

Gonzalez DE, Dickerson BL, Hines K et al. · 2026 · Sports (Basel, Switzerland)

There are concerns that high-dose and/or long-term creatine monohydrate supplementation (CrM) leads to greater side effects (SEs) compared to placebo. This analysis investigated whether the dose or duration of CrM was associated with SEs.…

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