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Browse the failure-mode index

21,277 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Model-based planning is unaffected by ketamine, antidepressant and internet delivered cognitive behavioural therapy treatments in depression.

Donegan KR, Hossein S, Panny BM et al. · 2025 · Translational psychiatry

Cognitive impairments have been observed in patients with depression. These include deficits in inhibition, shifting, and updating; cognitive processes that are critical for goal-directed control over behavior ('model-based planning').…

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Negative / Null Result ReportOpen accessMedicine

No Impact of COVID-19 Pandemic on Early Mortality for Thyroid Cancer in the US. Comment on Lee et al. Impact of the COVID-19 Pandemic on Thyroid Cancer Surgery. <i>Curr. Oncol.</i> 2024, <i>31</i>, 3579-3590.

Nocini R, Lippi G, Mattiuzzi C · 2024 · Current oncology (Toronto, Ont.)

Thyroid cancer is relatively rare in the general population compared to other malignancies, but its incidence appears to have increased in recent decades [...].

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Negative / Null Result ReportOpen accessMedicine

Cognitive and physiological impacts of psychotherapy incorporating human-equine interactions during substance withdrawal: A scoping review.

Friend MM, Nicodemus MC, Cavinder CA et al. · 2025 · Journal of equine rehabilitation

The use of psychotherapy incorporating equine interaction (PIE) is becoming widely utilized for the treatment of a range of conditions; however, evidence supporting the efficacy of this treatment is highly variable, inconsistently defined,…

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Negative / Null Result ReportMedicine

Synthetic Versus Biologic Mesh for Complex Open Ventral Hernia Repair: 3-Year Follow-Up of a Pilot Randomized Controlled Trial.

Dhanani NH, Lyons NB, Lee KH et al. · 2025 · HCA healthcare journal of medicine

Background Biologic mesh is often used in complex hernia repair, but there has been limited clinical evidence to date to support this practice. The aim of this study was to compare clinical and patient-reported outcomes of biologic versus…

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Negative / Null Result ReportMedicine

Derailment in adolescence: Factor analytic structure and correlates.

Ratner K, Zhu G, Li Q et al. · 2024 · Journal of research on adolescence : the official journal of the Society for Research on Adolescence

Derailment is the sense of being "off-course" in life. But what could this mean for adolescents, who are often establishing identity and self-direction for the first time? We examined the structure and correlates of the Derailment Scale…

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Negative / Null Result ReportMedicine

Early Sodium Bicarbonate Use in Pediatric In-Hospital Cardiac Arrest: A Single-Center, Retrospective Cohort Study, 2013-2023.

Duster NA, Grossestreuer AV, Sorcher JL et al. · 2025 · Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Objectives To explore the association of intra-arrest sodium bicarbonate (SB) use with outcomes in pediatric in-hospital cardiac arrest (p-IHCA) when accounting for the timing of initial SB administration. We hypothesized that…

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Negative / Null Result ReportMedicine

Sudden Sensorineural Hearing Loss Before COVID-19, During COVID-19, and After Inactivated Vaccination: Experience From a Tertiary Referral Center in China.

Cao X, Yi H · 2024 · Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

Objective The purpose of this study was to investigate the incidence rate and audiological characteristics of sudden sensorineural hearing loss (SSHL) before the COVID-19 pandemic, during the COVID-19 pandemic, and after inactivated…

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Negative / Null Result ReportOpen accessMedicine

Parent emotion regulation difficulties statistically mediate the association between parental adverse childhood experiences and child emotion regulation.

Freeman SE, Staples AD, Loverich TM et al. · 2025 · Frontiers in global women's health

Introduction Emotion regulation (ER) abilities predict positive outcomes among children. While parenting behaviors that promote young children's ER development have been widely studied, less is known about how a parent's history of early…

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Negative / Null Result ReportOpen accessMedicine

Less Than Zero?

Hackländer RPM, Schlüter H, Rolke AK et al. · 2025 · Experimental psychology

Not all information encountered is equally important to remember. Some information may be valuable, while others may be irrelevant. Importantly, retrieving and acting upon some information may even have negative consequences. Research has…

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Negative / Null Result ReportMedicine

Internalizing symptoms, negative urgency, and coping motives: Potential pathways to alcohol consequences.

McDonald A, Corbin W · 2025 · Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors

Objective Building upon prior research, the present study tested coping motives as a mediator of relations between both negative urgency and internalizing symptoms (depression, anxiety, and stress), and alcohol-related consequences using…

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Negative / Null Result ReportOpen access

No evidence that retinol is protective for skin cancer

Helder M, Pandeya N, Seviiri M et al. · 2024 · Preprint

ABSTRACT With over 1.5 million new cases annually, skin cancers are the most commonly diagnosed group of cancers worldwide. Among these, melanoma and keratinocyte cancers (KC), comprising squamous cell carcinoma (SCC) and basal cell…

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Abandoned HypothesisOpen accessMedicine

Finding Ramón: Navigating Failure and Luck in Mexico.

Jones GA · 2025 · Critical criminology

Failure is taboo. Yet as researchers we often encounter failure in the field and engage in confessional conversations with colleagues about 'what went wrong'. Failure is regarded as an unfortunate and unproductive part of research. Better…

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Negative / Null Result ReportOpen accessMedicine

Association between maternal serum levels of Alpha-Fetoprotein and eruption timing of the first central deciduous tooth: a cross-sectional study.

Faghihian E, Ghobadi S, Rezaei R et al. · 2025 · The Saudi dental journal

The current study investigated the relationship between the first central deciduous tooth eruption time and serum levels of maternal alpha-fetoprotein and related multiple of the median (MoM). The cross-sectional study was performed on a…

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Negative / Null Result ReportOpen accessMedicine

Exploring the effects of faecal microbiota transplantation on cognitive function: A review of clinical trials.

Alaeddin S, Chatterjee A, Roberts TL et al. · 2025 · Brain, behavior, & immunity - health

Faecal Microbiota Transplantation (FMT) is a widely used microbiota-modulation technique to treat recurrent Clostridioides difficile infections (rCDI). Rodent studies and clinical trials on probiotic interventions indicate that alterations…

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