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Browse the failure-mode index

21,710 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result Report

Fatal Human H3N8 Influenza Virus has a Moderate Pandemic Risk

Le Sage V, Vu MN, Maltepes MA et al. · 2025 · Preprint

In China, low pathogenic avian influenza (LPAI) H3N8 virus is widespread among chickens and has recently caused three zoonotic infections, with the last one in 2023 being fatal. Here we evaluated the relative pandemic risk of this 2023…

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Negative / Null Result ReportMedicine

Aortic Arch Morphology and Cerebrovascular Accidents After Transfemoral Transcatheter Aortic Valve Implantation.

Baltruskeviciute L, Moccetti F, Wolfrum M et al. · 2026 · The American journal of cardiology

Cerebrovascular accidents (CVA) after transcatheter aortic valve implantation (TAVI) remain a major concern. However, the impact of aortic arch morphology has not been investigated in this context. To address this gap, consecutive patients…

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Negative / Null Result ReportOpen accessMedicine

Impact of an Educational Programme in Primary Care for mothers With Infant Colic Babies: Quasi-Experimental Study.

Martínez-Lentisco MDM, Carreño-Segura S, León-Morillas F et al. · 2026 · Clinical pediatrics

This quasi-experimental study assessed the impact of a postpartum educational programme on health care utilization and maternal stress in mothers of infants with colic. A total of 84 mothers took part in 2 individual sessions, 15 days…

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Negative / Null Result ReportMedicine

Prophylactic norepinephrine infusion to reduce severe hypotension during induction of anaesthesia in patients undergoing cardiac surgery: a randomised controlled single-centre clinical trial.

Gaillard C, Breul L, Foucher A et al. · 2026 · British journal of anaesthesia

Background The EPITUBE trial aimed to determine whether a prophylactic infusion of norepinephrine reduced severe hypotension after induction of general anaesthesia and tracheal intubation in patients undergoing cardiac surgery. Methods We…

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Negative / Null Result ReportMedicine

Low dose of landiolol does not prevent postoperative atrial fibrillation after cardiac surgery in non-Asian patients: a multicentre randomised study.

Amour J, Naudin C, Besnard A et al. · 2026 · British journal of anaesthesia

Background Postoperative atrial fibrillation (POAF) affects 30% of patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Beta-blockers are the first-line agents recommended for POAF prevention. Landiolol, an…

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Negative / Null Result ReportMedicine

Effect of use of virtual reality on morphine-sparing in patients with sickle cell disease for main management of vaso-occlusive crises in an adult emergency department.

Dubreucq Guerif E, Agut S, Rousseau A et al. · 2026 · European journal of emergency medicine : official journal of the European Society for Emergency Medicine

Background and importance Vaso-occlusive crisis is the main reason for emergency department (ED) visits for patients with sickle cell disease. Therapeutic management involves multimodal analgesia, which often comprises the administration…

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Negative / Null Result Report

ZYS-1 is not an ADAR1 inhibitor

Smoak CN, Gardner EN, Chua RN et al. · 2025 · Preprint

Adenosine deaminase acting on RNA 1 (ADAR1) edits double-stranded RNA (dsRNA) substrates by the deamination of adenosine to inosine in a process known as A-to-I editing. Modulation of ADAR1 expression and editing activity has previously…

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Negative / Null Result ReportMedicine

Medial and Lateral Column Load Distribution After In Situ Subtalar/Talonavicular Fusion With and Without Calcaneocuboid Fusion: A Cadaveric Study.

Alkaramany E, Gallagher BP, Abbasi P et al. · 2025 · Foot & ankle international

Background Previous investigations have speculated that stiffening the lateral column of the hindfoot in triple arthrodesis can increase lateral plantar pressure with resulting lateral column pain. It is unclear whether sparing of the…

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Negative / Null Result ReportMedicine

Turning the tide: A randomized controlled trial of a brief digital mindfulness intervention to reduce immediate and delayed negative interpretation bias.

Wang Y, Wang S, Lin J et al. · 2026 · Journal of affective disorders

Objective The current study aimed to explore the effectiveness and mechanisms of mindfulness on alleviating both immediate and delayed negative interpretation biases (NIB). Method A total of 105 college students (female: 84.62 %, age:…

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Negative / Null Result ReportMedicine

Effect of standard wound dressing versus prophylactic closed incision negative-pressure therapy on surgical-site infection after open incisional hernia repair: multicentre randomized clinical trial.

Marckmann M, Henriksen NA, Krarup PM et al. · 2025 · The British journal of surgery

Background The benefit of closed incision negative-pressure therapy (ciNPT) after open incisional hernia repair in reducing surgical-site infection (SSI) is uncertain. Methods The PROPRESS multicentre RCT was conducted from 1 March 2023 to…

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Negative / Null Result Report

Postoperative Management After Penile Fracture Surgery: Intra-operative Drainage Does Not Reduce Early Morbidity After Penile Fracture Repair (FRACT AFUF project)

DE BREK N, PEYROTTES A, DARIANE C et al. · 2025 · Preprint

Abstract Purpose: Penile fracture is a rare urological emergency treated by surgical exploration. However, the indication for intra-operative drainage remains debated due to limited evidence. This study aimed to assess the impact of…

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Negative / Null Result ReportMedicine

Magnesium sulfate does not reduce propofol requirements but contributes to lower opioid consumption in bitches undergoing ovariohysterectomy.

Boff GA, Iepsen LB, Serighelli-Junior G et al. · 2025 · Veterinary research communications

This study aimed to evaluate the effects of magnesium sulfate on propofol requirements and perioperative analgesia in dogs undergoing ovariohysterectomy. Fourteen female dogs (2 ± 1 years, 17 ± 5 kg) were enrolled in this randomized and…

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Negative / Null Result ReportMedicine

The effects of marine fatty acid omega-3 supplements on incident fractures and bone mineral density in generally healthy adults.

LeBoff MS, Chou SH, Ratnarajah DM et al. · 2026 · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Although preclinical studies suggest that omega-3 fatty acids may benefit skeletal health, there are few randomized controlled trials investigating effects of supplemental omega-3 on bone outcomes. This VITamin D and OmegA-3 TriaL (VITAL)…

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Negative / Null Result ReportMedicine

Left Ventricular Unloading in Anterior ST-Segment Elevation Myocardial Infarction Without Shock: The ST-Segment Elevation Myocardial Infarction Door to Unload Randomized Controlled Trial.

Kapur NK, Mangner N, Aghili N et al. · 2026 · Journal of the American College of Cardiology

Background Despite rapid percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI), large infarcts contribute to heart failure and mortality. Left ventricular (LV) wall tension and load are major…

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