Prophylactic norepinephrine infusion to reduce severe hypotension during induction of anaesthesia in patients undergoing cardiac surgery: a randomised controlled single-centre clinical trial.
Gaillard C; Breul L; Foucher A; Rigal JC; David CH; Souab F; Canevet M; Ryan M · 2026 · British journal of anaesthesia
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Background The EPITUBE trial aimed to determine whether a prophylactic infusion of norepinephrine reduced severe hypotension after induction of general anaesthesia and tracheal intubation in patients undergoing cardiac surgery. Methods We…
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Metadata source: Europe PMC · DOI 10.1016/j.bja.2025.10.055