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Browse the failure-mode index

21,710 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Evaluation of predictive factors for conception after saline infusion sonosalpingography.

Ramadhan D, Al-Rasheedy M, Alsarraj L · 2026 · Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina

Objective For evaluation of predictive factors of sponataneous conception after saline infused sonosalpingography (SIS). Method A prospective study was conducted from August 2023 to December 2024 at reproductive medial unit  at…

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Negative / Null Result ReportMedicine

Clinical real-world data evaluation: comparison of central macular thickness after anti-VEGF treatment in diabetic macular edema patients treated with or without topical anti-glaucoma agents.

Baybora H, Özal E, Özal SA · 2026 · BMC ophthalmology

Background There are research findings suggesting that antiglaucoma agents may reduce aqueous humor outflow and decrease the elimination of intravitreally administered anti-vascular endothelial growth factor agents, prolonging their…

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Negative / Null Result ReportOpen accessMedicine

Mid-Term Oncological Outcomes of Vaginal Natural Orifice Transluminal Endoscopic Surgery Compared with Total Laparoscopic Hysterectomy for Early-Stage Endometrial Cancer: A Single-Center Retrospective Study.

Imai K, Abe J, Chikazawa K et al. · 2026 · Journal of clinical medicine

Background/Objectives : Vaginal natural orifice transluminal endoscopic surgery (vNOTES) is increasingly being used to avoid abdominal incisions; however, its mid-term oncological safety in endometrial cancer remains unclear. Methods :…

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Negative / Null Result ReportOpen accessMedicine

Alfentanil May Reduce Early Postoperative Nausea and Vomiting in Moderate-to-High Risk Patients Undergoing Gastrointestinal Endoscopy: A Prospective Double-Blind Randomized Study.

Gu XY, Cao JF, Zhang XY et al. · 2026 · Drug design, development and therapy

Objective This trial aimed to compare the effects of alfentanil and sufentanil on postoperative nausea and vomiting (PONV) in patients at moderate-to-high risk undergoing sedated gastrointestinal endoscopy. Methods Two hundred and eighteen…

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Negative / Null Result ReportOpen accessMedicine

Morphometrıc evaluatıon of patıents wıth mandıbular hypomobılıty due to coronoıd process hyperplasıa usıng cone beam computed tomography.

Kurt Akgül Ş, Boylu ÖF · 2026 · Surgical and radiologic anatomy : SRA

PURPOSE: Mandibular hypomobility is a condition in which the jaw joint is restricted due to various causes, including temporomandibular joint disorders (TMD), ankylosis, head and neck infections and tumors, coronoid processes hyperplasia…

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Negative / Null Result ReportOpen accessMedicine

Evaluation of multiple freeze-thaw cycles on growth factor and cytokine stability in canine platelet lysate: PDGF, TGF-<i>β</i>, and TNF-<i>α</i> preservation across cycles.

Sumner SM, Naskou MC · 2026 · Frontiers in veterinary science

Introduction Platelet-rich plasma (PRP) and platelet lysate (PL) are biologically active products used in regenerative medicine because of their high concentrations of growth factors, cytokines, and other bioactive molecules that promote…

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Negative / Null Result ReportMedicine

Observation on the clinical effects of four kinds of root canal filling materials in the treatment of chronic periapical periodontitis.

Wang K, Chen Y, Fu H et al. · 2026 · American journal of translational research

Objective To compare the clinical efficacy of four root canal filling materials for the treatment of chronic periapical periodontitis. Methods The clinical data of 200 patients with chronic periapical periodontitis from January 2023 to…

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Negative / Null Result ReportMedicine

Residual gastric content after holding of glucagon-like peptide-1 receptor agonists before elective surgery: a cross-sectional study - the RESIDUAL study.

Boudreau C, Couture M, Rousseau-Saine N et al. · 2026 · BMC anesthesiology

Introduction Glucagon-like peptide-1 receptor agonists (GLP-1 RA) are now increasingly used for glycemic control in type 2 diabetes mellitus as well as for weight loss. Their effect on gastric emptying may increase the risk of aspiration…

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Negative / Null Result ReportMedicine

Desflurane versus sevoflurane and postoperative inflammatory biomarkers in older adults undergoing minor- to moderate-risk noncardiac surgery.

Adamowitsch N, Reiterer C, Fleischmann E et al. · 2026 · Scientific reports

Volatile anesthetics modulate inflammatory responses, but it remains unclear whether desflurane and sevoflurane differ in their effects on postoperative inflammation. We evaluated in this secondary analysis of a prospective randomized…

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Negative / Null Result ReportOpen accessMedicine

Effects of acute HMB-FA supplementation on antioxidant status and muscle damage in Elite Judoka: a randomized pilot trial.

Tayebi SM, Mirzaei M, Stout JR · 2026 · Journal of the International Society of Sports Nutrition

Purpose High-intensity judo bouts induce oxidative stress and muscle damage, impairing recovery. This randomized, double-blind, placebo-controlled pilot trial examined whether acute β -hydroxy- β -methylbutyrate free acid (HMB-FA)…

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Negative / Null Result ReportOpen accessMedicine

CO<sub>2</sub>-Extract-Based Phytopreparation from <i>Arctium tomentosum</i> Mill. Root Exhibits No Acute and Subacute Toxicity and Suppresses Xylene-Induced Ear Edema and LPS-Induced Acute Inflammation in Mice.

Aitynova A, Dyusebaeva M, Issayeva D et al. · 2026 · Molecules (Basel, Switzerland)

A phytopreparation based on the CO 2 extract of Arctium tomentosum Mill. root (AT) was evaluated for its safety and anti-inflammatory potential in Swiss albino mice. Acute and 28-day subacute oral toxicity studies demonstrated that AT, at…

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Negative / Null Result ReportMedicine

Parameter Specific Modulation of Neuronal Firing and Extracellular Action Potential Dynamics by Transcranial Focused Ultrasound Stimulation in Rat Motor Cortex.

Huang H, Smets C, Chen L et al. · 2026 · Brain stimulation

Background Transcranial focused ultrasound stimulation (TUS) has emerged as a promising tool for noninvasive neuromodulation. However, the specific effects of stimulation parameters on neural activity remain incompletely understood.…

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