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Browse the failure-mode index

21,257 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

DNA metabarcoding for food authentication: identification of freshwater, marine, and terrestrial gastropods in commercial food products.

Andronache J, Cichna-Markl M, Dobrovolny S et al. · 2026 · NPJ science of food

Food fraud through species substitution has been reported for edible gastropods, particularly in processed products where morphological identification is not feasible. DNA-based methods have been used to identify gastropod species in food…

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Negative / Null Result Report

Anterior middle cingulate cortex gamma-aminobutyric acid level is elevated in children with both familial and prenatal alcohol exposure-associated attention deficit hyperactivity disorder

Alger JR, Gupta I, Farkouh L et al. · 2026 · Preprint

Background Prior neuroimaging suggests brain differences between children with attention deficit hyperactivity disorder due to prenatal alcohol exposure (ADHD+PAE) and non-exposed children with ADHD due to other, e.g., familial, causes…

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Negative / Null Result ReportMedicine

The Usefulness of Antinuclear Antibody Multiplex Immunoassay for Screening of Rheumatological Diseases: A Real-World Population-Based Study.

Hijaze E, Razi T, Arbel R et al. · 2026 · Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

Objective To evaluate the diagnostic performance of BioPlex 2200 multiplex immunoassay (BI) for detecting antinuclear antibodies (ANA), compared with the gold standard, the indirect immunofluorescence assay (IIF), as a screening…

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Negative / Null Result ReportMedicine

Early computed tomography may miss main pancreatic duct injury in distal pancreatic trauma: a prospective surgically verified diagnostic accuracy study.

Tri PM, Hung NT, Liet DH et al. · 2026 · Emergency radiology

Purpose To assess the diagnostic performance of computed tomography (CT) for predicting main pancreatic duct injury in surgically explored patients with distal pancreatic trauma. Methods We conducted a prospective single-center diagnostic…

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Negative / Null Result ReportMedicine

[Evaluation of the screening performance of ultrasound for fatty liver using transient elastography in the elderly population of Shanghai communities].

Wei XT, Zhu LY, Wu YL et al. · 2026 · Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

Objective: To evaluate the screening performance and related factors of ultrasound for hepatic steatosis in community-based elderly populations using controlled attenuation parameter (CAP) measured by transient elastography as the…

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Negative / Null Result Report

Diagnostic Accuracy of Magnetic Resonance Imaging versus Computed Tomography for Lumbar Spondylolysis in Patients with Chronic Low Back Pain: A Single-Center Retrospective Study

TEZCE A, DURMUŞ E · 2026 · Preprint

Abstract Purpose The objective of this study is to compare the diagnostic efficacy of Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) in detecting lumbar spondylolysis among patients presenting with chronic low back pain, and…

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Negative / Null Result ReportOpen accessMedicine

Diagnostic and therapeutic impact of PCR in uveitis: real-world data from intraocular fluid analysis of 45 uveitis patients in a tertiary referral center in Turkey.

Zorlutuna Kaymak N, Pekel İ, Demir Tekol S et al. · 2026 · BMC ophthalmology

Purpose To evaluate the diagnostic utility and real-world clinical impact of polymerase chain reaction (PCR) analysis of aqueous humor (AH) and vitreous samples in patients with uveitis including suspected infectious and mixed…

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Negative / Null Result ReportMedicine

[Expert consensus on newborn genetic screening process, interpretation of results, and recall (2026 Edition)].

Genetic And Metabolic Disorders Screening Subgroup Of The Birth Defects Prevention And Control Committee Chinese Preventive Medicine Association, Rare Diseases Branch Of Shandong Medical Association, Genetic Metabolism Branch Of Shandong Provincial Rare Disease Association et al. · 2026 · Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

High-throughput sequencing technology has recently been used in neonatal disease screening. To address the issues related to the screening process, interpretation of screening results, and recall of positive cases in neonatal genetic…

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Negative / Null Result ReportMedicine

18F choline PET/MR to assess clinically significant disease in prostate cancer: correlation with maximum and total cancer core length obtained via template mapping biopsies.

Haroon A, Almuhaideb A, Adeleke S et al. · 2026 · Nuclear medicine communications

Objective To assess the accuracy of 18F choline PET/magnetic resonance (MR) when compared with the reference standard MRI-guided template mapping (TPM) biopsies for evaluation of biochemical relapse of prostate cancer in patients with…

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Negative / Null Result ReportOpen accessMedicine

The sonographic Murphy sign: does analgesia matter?

Goldstein EL, Marcelo KR, Harjes WR et al. · 2025 · Emergency radiology

Purpose Controversy exists regarding analgesia premedication prior to right upper quadrant ultrasound (RUQUS) in the setting of abdominal pain when evaluating for acute cholecystitis (AC). The purpose of this study was to examine the…

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Failed Experiment ReportOpen accessMedicine

Comprehensive Cytogenetic Analysis Reveals Mosaicism in Newborn with Negative Prenatal Down Syndrome Screening: A Case Report.

Puppo I, Vardanyan A, Shahsuvaryan G et al. · 2025 · The American journal of case reports

BACKGROUND Down syndrome, or trisomy 21, is one of the most common chromosomal disorders associated with intellectual disability. Prenatal screening is a proactive approach to identify fetuses with common chromosomal abnormalities.…

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Null DatasetOpen accessMedicine

The unsung hero: <i>ntnh</i> gene as complementary botulism marker.

Valdezate S, Valiente M, Díaz-Ramón S et al. · 2026 · Frontiers in cellular and infection microbiology

Botulism is a rare but severe neurological disease caused by botulinum neurotoxins (BoNTs). Standard diagnostic methods including the mouse bioassay (SMB) and bont gene type-specific PCR, are often limited by the high genetic diversity…

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Null DatasetOpen accessMedicine

Diagnostic performance of the Sepsis qPCR MX-30<sup>®</sup> panel compared with conventional blood culture in pediatric febrile neutropenia: a single-center retrospective study.

Kurtipek FB, Yozgat AK, Gökçek E et al. · 2026 · BMC infectious diseases

Background Febrile neutropenia (FN) is a frequent and potentially life-threatening complication in patients with hematologic malignancies. Prompt and accurate identification of bloodstream pathogens is essential to optimize antimicrobial…

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Replication FailureMedicine

The Limited Utility of Synovial C-Reactive Protein in the Diagnosis of Knee and Hip Periprosthetic Joint Infection: Proposed New Diagnostic Cutoffs.

McCavitt DG, Culler MW, Palmer RC et al. · 2026 · The Journal of arthroplasty

Background The utility of synovial C-reactive protein (CRP) in diagnosing periprosthetic joint infection (PJI) remains controversial. This study examined the performance of synovial CRP for PJI diagnosis following total knee arthroplasty…

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Replication FailureMedicine

Case report: false-negative Xpert MRSA/SA BC result due to spa gene deletion in a patient with methicillin-resistant Staphylococcus aureus bacteremia.

Mura T, Aso M, Kawamura K et al. · 2025 · Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

Rapid diagnostic tests like the Xpert MRSA/SA BC assay are valuable for the early detection of Staphylococcus aureus (SA) and methicillin-resistant S. aureus (MRSA) in positive blood cultures. However, genetic variations in target regions…

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