Genome-wide association study identifies single-nucleotide polymorphism in KCNB1 associated with left ventricular mass in humans: The HyperGEN Study
Kraemer Rachel; Claas Steven A; Devereux Richard B; Rao Dabeeru C; Tang Weihong; Li Na; Arnett Donna K; Broeckel Ulrich · 2009 · BMC Medical Genetics
WASTE classifies this as Replication Failure · AI classification, approximate
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The finding, in one line
“However, subsequent studies have often failed to replicate these associations.”
Abstract
Abstract Background We conducted a genome-wide association study (GWAS) and validation study for left ventricular (LV) mass in the Family Blood Pressure Program – HyperGEN population. LV mass is a sensitive predictor of cardiovascular mortality and morbidity in all genders, races, and ages. Polymorphisms of candidate genes in diverse pathways have been associated with LV mass. However, subsequent studies have often failed to replicate these associations. Genome-wide association studies have unprecedented power to identify potential genes with modest effects on left LV mass. We describe here a
Abstract by Kraemer Rachel; Claas Steven A; Devereux Richard B; Rao Dabeeru C; Tang Weihong; Li Na; Arnett Donna K; Broeckel Ulrich, BMC Medical Genetics (2009) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1186/1471-2350-10-43