VEGFA Isoforms as Pro-Angiogenic Therapeutics for Cerebrovascular Diseases
Amanda Louise White; Gregory Jaye Bix · 2023 · Biomolecules
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
The finding, in one line
“However, VEGFA administration in clinical trials has thus far failed to replicate the promising results seen in animal models.”
Abstract
Therapeutic angiogenesis has long been considered a viable treatment for vasculature disruptions, including cerebral vasculature diseases. One widely-discussed treatment method to increase angiogenesis is vascular endothelial growth factor (VEGF) A. In animal models, treatment with VEGFA proved beneficial, resulting in increased angiogenesis, increased neuronal density, and improved outcome. However, VEGFA administration in clinical trials has thus far failed to replicate the promising results seen in animal models. The lack of beneficial effects in humans and the difficulty in medicinal trans
Abstract by Amanda Louise White; Gregory Jaye Bix, Biomolecules (2023) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.3390/biom13040702