Negative / Null Result ReportOpen accessMedicine
F Visalli, Matteo Capobianco, F. Cappellani et al. · 2026 · International Journal of Molecular Sciences
Mitochondrial dysfunction represents a central hallmark of aging and a broad spectrum of chronic diseases, ranging from metabolic to neurodegenerative and ocular disorders. Nicotinamide riboside (NR), a vitamin B3 derivative and efficient precursor of NAD+ (nicotinamide adenine dinucleotide), and berberine (BBR), an isoquinoline alkaloid widely investigated in metabolic regulation, have independently emerged as promising mitochondrial modulators. NR enhances cellular NAD+ pools, thereby activating sirtuin-dependent pathways, stimulating PGC-1α–mediated mitochondrial biogenesis, and triggering
View details →Negative / Null Result ReportOpen accessComputer Science
Sterling Williams-Ceci, Maurice Jakesch, Advait Bhat et al. · 2026 · Science Advances
Artificial intelligence (AI) writing assistants powered by large language models (LLMs) are increasingly used to make autocomplete suggestions to people as they write text. Can these AI writing assistants affect people’s attitudes in this…
View details →Negative / Null Result ReportOpen accessMedicine
Yi Zhang, Yanqi Han, Ying Sun et al. · 2026 · Signal Transduction and Targeted Therapy
Osteoarthritis (OA) is a debilitating joint disorder that causes chronic pain, inflammation, and detrimental bone alterations. Despite significant advances in understanding OA pathogenesis, current therapeutic strategies remain inadequate in halting disease progression or providing effective pain relief, highlighting unmet clinical needs. Recent insights into OA nociceptive pathways, inflammatory mediators, and organelle dysfunction have revealed promising therapeutic targets. Specifically, OA progression is driven by mitochondrial dysfunction (marked by accumulated damaged mitochondria with e
View details →Negative / Null Result ReportOpen accessMedicine
Sathish Babu Vasamsetti, Samreen Sadaf, Mohammad A. Uddin et al. · 2026 · Nature Communications
How cellular metabolism facilitates tissue-resident macrophage maintenance remains elusive. Here we show that visceral adipose tissue (VAT)-resident macrophages, unlike monocyte-derived macrophages, are enriched with mitochondrial-specific antioxidant enzymes restraining inflammation and promoting VAT homeostasis and insulin sensitivity. Additionally, VAT resident macrophages express high levels of plasminogen activator inhibitor type 2, encoded by SerpinB2, which is involved in the blood coagulation cascade. SerpinB2 promotes adipose resident macrophage survival by regulating mitochondrial ox
View details →Negative / Null Result ReportOpen accessEngineering
Cao Zhengzheng, Guo Fangxu, Rong Tao et al. · 2026 · Scientific Reports
Floor aquifers are responsible for approximately 55% of water inrush incidents in coal mines. As mining depths increase, the risk posed by confined floor aquifers becomes more severe. Grouting reinforcement and the sealing of water…
View details →Negative / Null Result ReportOpen accessDentistry
Chen Ding, Dize Li, Linzhu Su et al. · 2026 · International Journal of Oral Science
Nanotechnology has provided thousands of novel nano-antimicrobials possessing features uncommon in clinically available antimicrobials. Here, nanocarriers loaded with conventional antimicrobials and responding to environmental changes upon…
View details →Negative / Null Result ReportOpen accessEngineering
Bin Liu, Changfeng Yan, Ming Lv et al. · 2026 · Computers in Industry
Domain adaptation-based methods are extensively applied to predict the Remaining Useful Life (RUL) of rolling bearings under complex operating conditions. However, the nonlinear degradation process of bearings gives rise to markedly…
View details →Negative / Null Result ReportOpen accessMedicine
Qi Sun, Yanping Zhao, Simiao Qiao et al. · 2026 · Nature Communications
Radiotherapy can both activate and suppress immunity, making it difficult to predict or modulate these opposing effects for better cancer treatment. Boron neutron capture therapy (BNCT), a cellular-level radiotherapy, has demonstrated…
View details →Failed Experiment ReportOpen accessMedicine
Sahar Motamedi, Nina Ravoet, Jonas Dehairs et al. · 2025 · Nature Communications
Ferroptosis, a regulated form of cell death driven by lipid peroxidation, holds promise for targeting treatment-resistant cancer cells. Using a panel of melanoma cell lines, we uncover variability in the timing of ferroptosis onset upon…
View details →Negative / Null Result ReportOpen accessMedicine
Golan Carmi · 2025 · Education Sciences
Generative AI technologies are rapidly permeating higher education as innovative tools that support teaching and learning processes. This study investigates the integration of GenAI tools into academic learning and examines their influence on students’ learning effectiveness, attitudes, and satisfaction. A quantitative survey was administered to 485 college students. The findings indicate that students’ attitudes, satisfaction, and accumulated experience with GenAI constitute the most influential factors in promoting effective learning. Perceived advantages and disadvantages also play a substa
View details →Negative / Null Result ReportOpen accessPsychology
Gerui Xu, Shruthi Venkatesha Murthy, Bochen Jia · 2025 · Informatics
As AI decision support systems play a growing role in high-stakes decision making, ensuring effective integration of human intuition with AI recommendations is essential. Despite advances in AI explainability, challenges persist in fostering appropriate reliance. This review explores AI decision support systems that enhance human intuition through the analysis of 84 studies addressing three questions: (1) What design strategies enable AI systems to support humans’ intuitive capabilities while maintaining decision-making autonomy? (2) How do AI presentation and interaction approaches influence
View details →Negative / Null Result ReportOpen accessMedicine
Ruben P. A. van Eijk, Daphne N. Weemering, Sarah Opie-Martin et al. · 2025 · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Objective To characterize the natural history of the revised ALS functional rating scale (ALSFRS-R) over a 24-month period following initial assessment, and to assess its associations with survival.Methods Longitudinal ALSFRS-R…
View details →Negative / Null Result ReportOpen accessMedicine
Émilie Le Rhun, Lakshmi Nayak, Mary Jane Lim-Fat et al. · 2024 · Neuro-Oncology
BACKGROUND: There are no validated tools for the clinical neurological assessment of patients with leptomeningeal metastases (LM). However, clinical examination during the course of the disease guides medical management and is part of response assessment in clinical trials. Because neuroimaging may not always be obtained owing to rapid clinical deterioration, clinical neurological assessment of LM is essential, and standardization is important to minimize rater disagreement. METHODS: The Response Assessment in Neuro-oncology-LM group launched a 2-step process, aiming at improving and standardi
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Alina Marculetiu, Çiğdem Ataseven, Injazz J. Chen · 2025 · Business Ethics the Environment & Responsibility
ABSTRACT This study investigates the effectiveness of institutional pressures in motivating two contrasting sustainability strategies, symbolic and substantive, and their subsequent impact on the triple bottom line (TBL). Using data from…
View details →Negative / Null Result ReportOpen accessMedicine
Solveigh C. Koeberle, Maria Thürmer, Fengting Su et al. · 2025 · Theranostics
: Our study deciphers the structural features of silybin contributing to hepatic lipid remodeling and suggests that silymarin/silybin protects the liver in individuals with mild metabolic dysregulation, involving a lipid class switch from triglycerides to phospholipids, whereas it may be less effective in disease states associated with severe metabolic dysregulation.
View details →Negative / Null Result ReportOpen accessEngineering
M. A. Huque, Leon M. Tolbert, Benjamin J. Blalock et al. · 2026 · IMAPSource Proceedings
High-temperature power conversion modules (DC-DC converters, inverters, etc.) have enormous potential in extreme environment applications, including automotive, aerospace, geothermal, nuclear, and well logging. Power-to-volume and…
View details →Replication FailureOpen accessMedicine
Nicholas A. Marston, Erin A. Bohula, Ajay Bhatia et al. · 2026 · JAMA
Importance: Intensive lowering of low-density lipoprotein cholesterol (LDL-C) levels with PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors for cardiovascular event reduction has largely been reserved for patients with…
View details →Negative / Null Result ReportOpen accessEngineering
Bianca Menzani, Priscille De Gea, Xavier Gidrol et al. · 2026 · Lab on a Chip
models for studying human physiology, development and disease. Their potential is very important and they have broad applications, but their impact is currently limited by persistent challenges such as incomplete maturation, batch…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Amalie Kjær Andresen, Mathilde Sophie Felding, Margarida M. A. Sacramento et al. · 2025 · Journal of Controlled Release
Bacterial biofilms pose a significant clinical challenge due to their intrinsic resistance to antibiotics and immune clearance. Traditional systemic antibiotic therapies are often ineffective against the structured microbial communities, emphasizing the urgent need for localized and targeted drug delivery systems. Hydrogels are three-dimensional, water-rich polymeric networks, and have emerged as a versatile platform for localized delivery of antimicrobial agents, offering controlled release, biocompatibility and the potential for functionalization with bioactive components. This review explor
View details →Negative / Null Result ReportOpen accessMedicine
Florian Missey, Emma Acerbo, Adam S. Dickey et al. · 2025 · Brain stimulation
INTRODUCTION: Medication-refractory focal epilepsy creates a significant clinical challenge, with approximately 30 % of patients deemed ineligible for surgery due to involvement of eloquent cortical regions within the epileptogenic network. For these patients, electrical neuromodulation represents a promising alternative therapy. We investigated the potential of non-invasive temporal interference (TI) electrical stimulation in reducing epileptic biomarkers in patients with mesiotemporal epilepsy (MTLE) MATERIAL AND METHOD: Thirteen patients implanted with stereoelectroencephalography (sEEG) de
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Anna Barton, Maciej Jaśkiewicz, Anna Więch -Walów et al. · 2025 · Cell Communication and Signaling
Abstract The cellular and tissue response to acute hypoxia is mediated by a complex adaptive response initiated by hypoxia-inducible factors (HIF) 1 and 2. HIF proteins are key transcription factors that modulate gene expression to adapt cells to the low oxygen tension. Cellular studies of hypoxia have used the low oxygen model by using hypoxia chambers to monitor the gene expression changes, while others have utilized hypoxia mimetics in normoxic conditions. Here, we provide a comparison of the utility and limitations of two hypoxia mimetics by studying the changes in the miRNA and mRNA expre
View details →Replication FailureOpen accessMedicine
Mette Kruse Klausen, Signe Justesen, Julie Niemann Pedersen et al. · 2026 · The Lancet
BACKGROUND: Alcohol use disorder accounts for 5% of deaths worldwide annually, and there is an urgent need for new therapeutic interventions. Preclinical and initial human studies indicate that the GLP-1 receptor agonist semaglutide might reduce alcohol drinking. This study evaluated the efficacy of semaglutide once-weekly in treatment-seeking patients with alcohol use disorder and comorbid obesity. METHODS: In a 26-week, single-centre, randomised, double-blinded, placebo-controlled trial, treatment-seeking participants with moderate to severe alcohol use disorder and comorbid obesity were ass
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
S. H. Suyu, Ana Acebrón, C. Grillo et al. · 2026 · Astronomy and Astrophysics
Robust mass modeling of strong-lensing galaxy clusters is crucial for studying cosmology and galaxy evolution. We present and compare seven mass models of the galaxy cluster MACS J0138−2155, constructed using six independent modeling software programs, including parametric and free-form approaches. By conducting a blind analysis where all the mass-modeling teams constructed their models independently without exchanging results, we quantified uncertainties arising from modeling software and assumptions. MACS J0138−2155 is unique as the only cluster found to strongly lens two supernovae (SNe), R
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
R. Abbasi, M. Ackermann, J. Adams et al. · 2026 · The Astrophysical Journal Letters
Abstract Recently, IceCube reported neutrino emission from the Seyfert galaxy NGC 1068. Using 13.1 yr of IceCube data, we present a follow-up search for neutrino sources in the northern sky. NGC 1068 remains the most significant neutrino source among 110 preselected gamma-ray emitters while also being spatially compatible with the most significant location in the northern sky. Its energy spectrum is characterized by an unbroken power-law with spectral index γ = 3.4 ± 0.2. Consistent with previous results, the observed neutrino flux exceeds its gamma-ray counterpart by at least 2 orders of magn
View details →Negative / Null Result ReportOpen accessEngineering
Lihua Liang, Xiaodong Li, Shutong Liu et al. · 2026 · Buildings
This study develops and applies an integrated methodology that combines deep learning-based computer vision and spatial statistics to automate the large-scale identification and analysis of morphological features in vernacular courtyard dwellings. Focusing on Liangshuaixiu dwellings in Wu’an, southern Hebei, we trained an HRNetV2 semantic segmentation model on high-resolution satellite imagery to identify and extract contours for 134,280 courtyard spaces. Core morphological parameters (area, orientation) were calculated and analyzed using GIS spatial statistics and the geographic detector mode
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Ming Yi, Tianye Li, Yinhui Gu et al. · 2026 · Nature Communications
Antibodies targeting TGF-β and PD-L1 initially showed promise as second-generation PD-L1 agents. However, consecutive trial failures have limited their clinical success. Our study reveals that the efficacy of the TGF-β×PD-L1 bispecific…
View details →Negative / Null Result ReportOpen accessEngineering
Lina Maria Ellegård, Gustav Kjellsson, Linn Mattisson · 2026 · The Economic Journal
Abstract The emergence of markets for on-demand online physician consultations —direct-to-consumer telemedicine (DCT) — is currently transforming many healthcare settings. DCT may be a cost-effective substitute for in-person consultations, but the convenience of seeking DCT may increase the demand for the service and consequently also the costs for health insurers. To causally assess the degree to which DCT consultations substitute for in-person primary care consultations, we exploit exogenous changes in patient fees in a fuzzy difference-in-discontinuities analysis of young adults in Sweden.
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
A. J. Nayana, R. Margutti, Eli Wiston et al. · 2025 · The Astrophysical Journal Letters
Abstract We present X-ray (0.3–79 keV) and radio (0.25–203 GHz) observations of the most luminous fast blue optical transient (LFBOT) AT 2024wpp at z = 0.0868, spanning 2–280 days after first light. AT 2024wpp shows luminous ( L X ≈ 1.5 × 10 43 erg s −1 ), variable X-ray emission with a Compton hump peaking at δt ≈ 50 days. The X-ray spectrum evolves from a soft ( F ν ∝ ν −0.6 ) to an extremely hard state ( F ν ∝ ν 1.26 ) accompanied by a rebrightening at δt ≈ 50 days. The X-ray emission properties favor an embedded high-energy source shining through asymmetric expanding ejecta. We detect radi
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Wenying Huo, Yingying Qiao, Xiangru He et al. · 2025 · Toxins
Mycotoxins are toxic secondary metabolites produced by filamentous fungi that contaminate agricultural commodities, posing risks to food safety, animal productivity, and human health. The gastrointestinal tract is the first and most critical site of exposure, where the intestinal epithelium functions as both a physical and immunological barrier against luminal toxins and pathogens. While extensive research has demonstrated that mycotoxins disrupt epithelial integrity through tight junction impairment, oxidative stress, apoptosis, and inflammation, their effects on the intestinal stem cell (ISC
View details →Negative / Null Result ReportOpen accessEngineering
Fhysmélia Firmino de Albuquerque, Rodrigo M. Iost, Frank N. Crespilho · 2025 · ACS Measurement Science Au
The development of enzyme-based bioelectronic devices, including biosensors and biomimetic systems, has significantly advanced with the introduction of innovative materials such as hydrogels, deep eutectic solvents (DES), and ionic liquids (ILs). These materials offer unique advantages in enhancing biodevice performance, particularly in enzyme stabilization, biocompatibility, and electrochemical sensitivity. Hydrogels, known for their high water content and flexibility, provide an ideal matrix for enzyme immobilization in biological applications but are limited by low ionic conductivity. DES,
View details →