Negative / Null Result ReportOpen accessEngineering
Mohamed Abdellatief, Mohamed Mortagi · 2026 · Scientific Reports
Accurate prediction of the unconfined compressive strength (UCS) of geopolymer-stabilized clayey soil is critical for geotechnical engineering. Conventional regression algorithms and even advanced machine learning approaches such as artificial neural networks often struggle to fully capture the highly non-linear interactions among soil properties and geopolymer mix parameters while maintaining computational efficiency and interpretability on limited datasets. To address these challenges, this investigation proposes a novel hybrid predictive framework based on a sector fruit fly optimization al
View details →Replication FailureOpen accessMedicine
Wungki Park, Catherine O’Connor, Joanne F. Chou et al. · 2026 · Nature Medicine
Homologous recombination deficiency (HRD) arising from BRCA1or BRCA2 or PALB2 mutations confers sensitivity to platinum chemotherapy and PARP inhibition in pancreatic cancer (PC) and may enable prolonged disease control with immune checkpoint blockade (ICB). The phase 2 POLAR trial evaluated maintenance pembrolizumab plus olaparib following platinum-based chemotherapy in biomarker-stratified metastatic PC. Sixty-three participants were enrolled into three cohorts: cohort A (BRCA1/BRCA2-mutated or PALB2-mutated HRD, n = 33), cohort B (non-core HRD, n = 15) and cohort C (platinum sensitive, HRD-
View details →Negative / Null Result ReportOpen accessPharmacology, Toxicology and Pharmaceutics
Remonda Raafat Ragheb, Rodayana Atef, Kareem Abdou et al. · 2026 · AAPS PharmSciTech
Abstract Venous thromboembolism (VTE) and pulmonary embolism (PE), remains a major global health burden, necessitating prolonged and reliable anticoagulant therapy. Although Apixaban (APX) is a cornerstone oral anticoagulant for VTE management, its therapeutic performance is limited by poor aqueous solubility and low oral bioavailability. To overcome these challenges, this study introduces a hybrid niosomal delivery system designed to enhance the absorption and systemic persistence of APX. The system was engineered by integrating hybrid of surfactants together with cholesterol to form a stable
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Zhenghao Sun, Qian Gong, Zi-lai Wang et al. · 2026 · International Journal of Biological Sciences
The gut microbiota, as a source of profound genetic and metabolic capacity, affects every aspect of human biology including health, development and aging, as well as disease. Studies have demonstrated the crosstalk between the gut…
View details →Negative / Null Result ReportOpen accessMedicine
Xiaohua Xiao, Xueqin Yan, Chunhua Liang et al. · 2026 · Frontiers in Neurology
Alzheimer's disease (AD) is a gradual and irreversible decline in the brain's ability to function which is not only signified by amyloid-beta plaques and neurofibrillary tangles but also by and metabolic and mitochondrial changes that have a negative impact on the classical neuropathological hallmarks. It is becoming increasingly clear that the central roles in the process of synaptic dysfunction, neuronal death and cognitive decline are played by the brain's impaired glucose utilization, insulin resistance, lipid metabolism alterations, and energy homeostasis disruption. Mitochondrial dysfunc
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Lucia Chico, Erika Schirinzi, Linda Balestrini et al. · 2026 · International Journal of Molecular Sciences
Neurodegenerative diseases (NDs) are among the leading causes of disability and mortality worldwide and are characterized by multifactorial pathogenesis involving interconnected mechanisms, such as oxidative stress, protein misfolding and aggregation, neuroinflammation, and mitochondrial dysfunction. Dysregulation of transcription factors, governing cellular defense responses, particularly nuclear factor erythroid 2-related factor 2 (Nrf2), a key regulator of antioxidant and proteostatic pathways, plays a critical role in neurodegenerative processes. Currently, available pharmacological treatm
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Moritz Mager, Lukas Zeilerbauer, Alexander Felgel-Farnholz et al. · 2026 · Waste Management
European legislation, particularly the Packaging and Packaging Waste Regulation (PPWR), is rapidly increasing the demand for high-quality recycled polypropylene (PP) in packaging applications. Achieving such qualities through mechanical recycling remains challenging due to the heterogeneity of post-consumer waste, while the role of intensified washing in the overall decontamination remains debated. This study evaluates the influence of additional sorting and washing intensity on material properties, product performance, and environmental impacts in mechanical recycling of Dutch post-consumer r
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
L E Mayorga, Arnau Noguera Segura, Laura Campderros et al. · 2026 · Gut
BACKGROUND: Inflammatory bowel disease (IBD) arises from complex interactions among diet, host and gut microbiome. Although diet influences intestinal inflammation, the microbial and metabolic pathways involved, and their differences…
View details →Replication FailureOpen accessMedicine
Lizl Veldsman, GA Richards, D. G. Nel et al. · 2025 · Journal of Parenteral and Enteral Nutrition
BACKGROUND: Muscle wasting is a hallmark of critical illness. We evaluated the effect of amino acid supplementation and mobilization on early muscle loss in critically ill patients. METHODS: We conducted a randomized parallel-group trial…
View details →Replication FailureOpen accessMedicine
Jennifer Duffecy, Arfa Rehman, Scott Gorman et al. · 2025 · JMIR mhealth and uhealth
Unlabelled: Background: Perimenopausal and menopausal symptoms affect many women's well-being and quality of life. Digital technologies, especially smartphones, allow self-management interventions for menopausal symptoms, but they are understudied., Objective: We evaluated whether a novel digital care app, Caria, effectively reduced vasomotor and behavioral health symptoms of menopause., Methods: We enrolled 149 women for a 6-week randomized controlled trial (app treatment: n=112; web-based educational control: n=37). Enrolled participants had problematic vasomotor symptoms and at least one el
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Tomasz Kulik, Paulina Staniszewska, Patryk Wiśniewski et al. · 2025 · Frontiers in Microbiology
Products derived from Trichoderma fungi, primarily marketed as biofungicides and biofertilizers, are widely utilized to promote sustainable and regenerative farming practices. In this study, we characterized Trichoderma -based products currently available in both international and local (the Polish) markets. We estimated the number of viable cells in these products, which is a key factor boosting their efficacy. We found substantial differences in the number of colony-forming units (CFUs) among various products, with all products exhibiting fewer CFUs than claimed. The degree of this inconsist
View details →Negative / Null Result ReportOpen accessMedicine
Claudiu Stoicescu, Cristina Văcărescu, Dragoș Cozma · 2025 · Journal of Clinical Medicine
High-density lipoprotein (HDL) and small dense low-density lipoprotein (sdLDL) represent two critical yet contrasting components in lipid metabolism and cardiovascular risk modulation. While HDL has traditionally been viewed as cardioprotective due to its role in reverse cholesterol transport and anti-inflammatory effects, emerging evidence emphasizes that HDL functionality-rather than concentration alone-is pivotal in atheroprotection. Conversely, sdLDL particles are increasingly recognized as highly atherogenic due to their enhanced arterial penetration, oxidative susceptibility, and prolong
View details →Negative / Null Result ReportOpen accessMaterials Science
Emrah Yıldırım, J. Naish, J. Trueba et al. · 2026 · Nuclear Fusion
Abstract An integrated tritium fuel-cycle architecture has been developed for ST-E1, a low-aspect-ratio, high-power fusion power plant. The approach couples a helium-cooled liquid-lithium breeder blanket with a dedicated circulation loop providing tritium extraction, heat removal, and inventory control within a unified system boundary. Downstream of the blanket, the tritium processing system comprises of extraction, purification, isotope separation, and storage subsystems sized to accommodate the plant’s dynamic tritium production and consumption rates. Inventory modelling is used to assess ca
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Byong Duk Ye, Hyo Jong Kim, Dongil Park et al. · 2026 · Journal of Gastroenterology and Hepatology
BACKGROUND AND AIM: The incidence of ulcerative colitis (UC) has been increasing in Asia. Comprehensive data on the long-term course of moderate-to-severe UC remain scarce. This study investigated the clinical outcomes and factors…
View details →Negative / Null Result ReportOpen accessNeuroscience
Elena Krugliakova, Friederike Breuer, Nico Adelhöfer et al. · 2025 · Physiological Reviews
Sleep is essentially contributing to human health and well-being through multiple biological functions, including restoration and biosynthesis, brain clearance, energy metabolism, immunological and endocrine processing, synaptic…
View details →Negative / Null Result ReportOpen accessEngineering
Justyna Kujawska, Wojciech Cel, B. Charmas et al. · 2026 · Energies
Biochar obtained from digestate is a promising material in the context of digestate management. However, it is important to note that the properties of the resulting material are largely dependent on the parameters of the pyrolysis process, with temperature being a particularly significant factor. The objective of this study was to evaluate the impacts of the digestate pyrolysis temperature on the chemical structure, thermal stability, and thermal decomposition characteristics of biochar produced at temperatures of 400, 500, 600, and 800 °C in an inert nitrogen atmosphere. Material characteriz
View details →Negative / Null Result ReportOpen accessSocial Sciences
Mohammad Hadra, Karleen Cambridge, Mostefa Mesbah · 2026 · International Journal for Educational Integrity
The rapid adoption of generative AI (GenAI) in higher education has intensified concerns about academic integrity, particularly for institutions serving English as a Foreign Language (EFL) learners. AI content detectors such as Turnitin…
View details →Replication FailureOpen accessMedicine
Christopher C. Butler, Andrew Pinto, Victoria Harris et al. · 2026 · New England Journal of Medicine
BACKGROUND: Nirmatrelvir-ritonavir has been shown to reduce progression to severe illness from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in unvaccinated high-risk outpatients. The effectiveness of nirmatrelvir-ritonavir in persons who have been vaccinated, infected naturally, or both is unclear. METHODS: In two open-label platform trials (PANORAMIC in the United Kingdom and CanTreatCOVID in Canada), we enrolled higher-risk adults (≥50 years of age or ≥18 years of age with coexisting conditions) in the community who tested positive for SARS-CoV-2 and had been unwell for 5 day
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
K. D. Alexander, R. Margutti, Sebastian Gomez et al. · 2026 · The Astrophysical Journal
Abstract Recent observations presented in Y. Cendes et al. show that optically selected tidal disruption events (TDEs) commonly produce delayed radio emission that can peak years after disruption. Here, we explore the multiwavelength properties of a sample of radio-observed optically selected TDEs, to shed light on the physical process(es) responsible for the late-rising radio emission. We combine new late-time X-ray observations with archival optical, UV, X-ray, and radio data to conclude that a diversity of accretion-driven outflows may power the delayed radio emission in TDEs. Our analysis
View details →Negative / Null Result ReportOpen accessEngineering
MD Irteeja Kobir, Pedro Machado, Ahmad Lotfi et al. · 2025 · Sensors
Human Activity Recognition (HAR) is crucial for understanding human behaviour through sensor data, with applications in healthcare, smart environments, and surveillance. While traditional HAR often relies on ambient sensors, wearable devices or vision-based systems, these approaches can face limitations in dynamic settings and raise privacy concerns. Device-free HAR systems, utilising Wi-Fi Channel State Information (CSI) to human movements, have emerged as a promising privacy-preserving alternative for next-generation health activity monitoring and smart environments, particularly for multi-u
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Rong Yuan, Tajul Ariffin Masron, Yujie Chen et al. · 2025 · International Journal of Environmental Science and Technology
Abstract The alarming rate of environmental degradation worldwide has prompted a renewed focus on government effectiveness as an essential factor affecting environmental quality. Few studies have demonstrated the role of government effectiveness in environmental degradation under the influence of economic development. Consequently, this study aims to investigate the effect of government effectiveness and how it impacts environmental degradation using panel data from 61 regions from 2007 to 2021 and the generalized method of moments (GMM) estimator. The results show that improving government ef
View details →Negative / Null Result ReportOpen accessPhysics and Astronomy
I. Delvecchio, E. Daddi, B. Magnelli et al. · 2025 · Astronomy and Astrophysics
Little red dots (LRDs) are a puzzling population of extragalactic sources whose origin is highly debated. In this work, we performed a comprehensive stacking analysis of NIRCam, MIRI, and ALMA images of a large and homogeneously selected sample of LRDs from multiple JWST Legacy fields. We report clear evidence of hot-dust emission in the median stacked spectral energy distribution (SED) that features a rising near-infrared continuum up to rest-frame λ rest ∼ 3 μm, which is best explained by a standard dusty active galactic nucleus (AGN) structure. Although LRDs are likely to be a heterogeneous
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Eric Kernfeld, Yunxiao Yang, Joshua S. Weinstock et al. · 2025 · Genome biology
Diverse machine learning methods promise to forecast gene expression changes in response to novel genetic perturbations. However, these methods' accuracy is not well characterized. We created a benchmarking platform that combines a panel…
View details →Negative / Null Result ReportOpen accessEngineering
Yu‐Hui Zhang, Lu-Qiang Wei, Chen-Shuang Liu et al. · 2025 · ACS Omega
High Resolution Image Download MS PowerPoint Slide Pesticides are of great significance in ensuring food yield. However, the extensive use of pesticides has led to severe environmental pollution and significant economic losses.…
View details →Negative / Null Result ReportOpen accessPsychology
Chantal A. Miller, Keshun Zhang, Ronald Hübner · 2025 · Humanities and Social Sciences Communications
Abstract Aesthetic preferences vary widely among individuals and across cultures. These culture-specific aesthetic preferences are reflected in the environment, artistic behaviour, and consumer choices. People have the ability to infer the aesthetic preferences of others within their own culture through their Theory of Aesthetic Preferences , which is a subcategory of the Theory of Mind. An important question is whether people can also infer aesthetic preferences across different cultures. This study aimed to investigate aesthetic preference and aesthetic inference, as well as the underlying m
View details →Negative / Null Result ReportOpen accessMedicine
Fedir Hladkykh, Tetiana Liadova, Mariia Matvieienko et al. · 2026 · Journal of Pain Research
Introduction: Central sensitization explains the mismatch between structural damage or inflammation and pain intensity in chronic musculoskeletal diseases. It defines the phenotype of fibromyalgia and contributes to persistent pain in…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Yashvee Dunneram, Jia Yi Lee, Cody Z. Watling et al. · 2026 · British Journal of Cancer
BACKGROUND: Vegetarian diets might influence cancer risk. METHODS: We studied 1,645,555 meat eaters, 57,016 poultry eaters, 42,910 pescatarians, 63,147 vegetarians and 8849 vegans in 9 cohorts (UK, US, Taiwan, India). After a median 16 years follow-up, incident cancers were: 4504 mouth and pharynx, 1308 oesophagus (squamous cell), 2105 oesophagus (adenocarcinoma), 3578 stomach, 30,528 colorectum, 2970 liver, 8030 pancreas, 3077 lung (never smokers), 61,368 breast, 11,220 endometrium, 8076 ovary, 45,946 prostate, 7193 kidney, 6869 bladder, 11,651 non-Hodgkin lymphoma, 4658 multiple myeloma and
View details →Replication FailureOpen accessMedicine
Junren Chen, Siqi Qin, Ziwei Xing et al. · 2026 · Cellular & Molecular Biology Letters
BACKGROUND: Diabetic wounds are a debilitating complication of diabetes mellitus with a high rate of amputation and mortality. 6-Hydroxyhyoscyamine hydrobromide (6-HH) is a belladonna alkaloid with smooth-muscle-relaxing and…
View details →Negative / Null Result ReportOpen accessMedicine
Cristina Migliore, Elisabetta Fenocchio, Silvia Giordano et al. · 2025 · Cancer Treatment Reviews
Gastric cancer (GC) is the third leading cause of cancer-related mortality worldwide, and is associated with a very poor prognosis, largely due to its aggressive nature and, typically, late-stage diagnosis. Molecular classifications proposed one decade ago have provided valuable insights into the disease's heterogeneity and paved the way for clinical trials of tailored treatments. However, most of these trials have failed, often due to inadequate patient selection, lack of reliable biomarkers of response/resistance, or for the high level of inter- and intra-tumor heterogeneity characterizing t
View details →Negative / Null Result ReportOpen accessMedicine
Steffen Tiedt, Alejandro Bustamante, Alan Cameron et al. · 2026 · The Lancet Neurology
The complexity and incomplete understanding of the pathophysiology of stroke poses substantial challenges to personalised medicine and the development of novel therapies, as reflected in the neutral results of many randomised trials. Current clinical algorithms lack the precision to diagnose stroke before hospital admission, predict disease progression and recovery, or assess recurrence risk. Biomarkers are urgently needed, yet the absence of a robust evidence base hinders their clinical translation. To lay the groundwork for addressing this knowledge gap, an international multidisciplinary pa
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