AMP-activated protein kinase-driven lipid droplet dynamics govern melanoma sensitivity to polyunsaturated fatty acid and iron-induced ferroptosis
Sahar Motamedi; Nina Ravoet; Jonas Dehairs; Frank Vanderhoydonc; Abril Escamilla‐Ayala; Małgorzata Alicja Śliwińska; Shuncong Wang; Jakub Idkowiak · 2025 · Nature Communications
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Abstract (excerpt)
Ferroptosis, a regulated form of cell death driven by lipid peroxidation, holds promise for targeting treatment-resistant cancer cells. Using a panel of melanoma cell lines, we uncover variability in the timing of ferroptosis onset upon…
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Metadata source: OpenAlex · DOI 10.1038/s41467-025-66113-z