Negative / Null Result ReportOpen accessChemistry
Weida Wang, Chunqi Wang, Baocheng Zhao et al. · 2026 · Foods
Soybean protein content is a key indicator of nutritional value and quality grade, and its determination is important for quality evaluation and cultivar selection. To overcome the time-consuming and costly limitations of conventional chemical assays, this study proposed a multiple linear learner ensemble importance-score wavelength selection (MLLEISWS) method to identify informative wavelengths from soybean near-infrared spectra and establish a partial least squares (PLS) model. MLLEISWS was compared with competitive adaptive reweighted sampling, successive projections algorithm, and uninform
View details →Negative / Null Result ReportOpen accessComputer Science
Prabha M. Kumarage, Mirka Saarela · 2026 · AI
Generative Artificial Intelligence (GenAI) models produce increasingly sophisticated outputs, yet their underlying mechanisms remain opaque. To clarify how explainability is conceptualized and implemented in GenAI research, this two-stage review systematically examined 261 articles retrieved from six major databases. After removing duplicates and applying predefined inclusion criteria, 63 articles were retained for full analysis. In the first stage, an umbrella review synthesized insights from 18 review papers to identify prevailing frameworks, strategies, and conceptual challenges surrounding
View details →Negative / Null Result ReportOpen accessNeuroscience
Dawn Finzi, Eshed Margalit, Kendrick Kay et al. · 2026 · Nature Communications
Human visual cortex is organized into dorsal, lateral, and ventral streams. A long-standing hypothesis is that the functional organization into streams emerged to support distinct visual behaviors. Here, we compare neural network-based…
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Suresh Raja Neethirajan · 2026 · Agriculture
Digital twin technology is widely promoted as a transformative step for precision live-stock farming, yet no fully realized, engineering-grade digital twins are deployed in commercial dairy or poultry systems today. Existing platforms are better described as near-digital-twin systems with partial sensing and modelling, digital-twin-inspired prototypes, simulation frameworks or decision-support tools that are often labelled as twins despite lacking continuous synchronization and closed-loop control. This distinction matters because the empirical foundation supporting many claims remains limited
View details →Negative / Null Result ReportOpen accessSocial Sciences
Jamie Lars Hanson, Dorthea J Adkins, Brendon M. Nacewicz et al. · 2026 · Brain and Environment
Socioeconomic status (SES) in childhood can impact behavioral and brain development. Past work has consistently focused on the amygdala and hippocampus, two brain areas critical for emotion and behavioral responding. While there are SES differences in amygdala and hippocampal volumes, there are many unanswered questions in this domain connected to neurobiological specificity, and for whom these effects may be more pronounced. We may be able to investigate some anatomical subdivisions of these brain areas, as well as if relations with SES vary by participant age and sex. No work to date has how
View details →Negative / Null Result ReportOpen accessMaterials Science
Abhilash Purohit, S. Sathees Kumar, Pravat Ranjan Pati et al. · 2026 · Scientific Reports
Abstract The growing demand for sustainable materials has stimulated the development of bio-based composites, yet the combination of natural fibers and industrial waste fillers in polymer matrices has not been exploited synergistically. In line with Sustainable Development Goal 12 (SDG-12), the paper focuses on reusing the steel industry by-product Linz–Donawitz (LD) sludge to enhance the mechanical properties of epoxy composites when used with the jute fiber. Six composite specimens with constant jute fiber loading (20 wt%) and a range of LD sludge content (0–25 wt%) were prepared using hand
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
António Afonso, José Alves, João Jalles et al. · 2026 · Scottish Journal of Political Economy
ABSTRACT We examine how geopolitical risks (GPR) affect fiscal (FS) and external sustainability (ES) across 27 European Union economies over 2001Q4–2022Q3. We apply a two‐step strategy: first, estimating time‐varying FS and ES coefficients…
View details →Replication FailureOpen accessMedicine
Jeremy M. Shefner, Merit Cudkowicz, Angela L. Genge et al. · 2025 · JAMA Neurology
Importance: Treatment options for amyotrophic lateral sclerosis (ALS) remain suboptimal. Results from a phase 2 study of reldesemtiv in ALS suggested that it may slow disease progression. Objective: To assess the effect of reldesemtiv vs…
View details →Negative / Null Result ReportOpen accessMedicine
Mathilde Duchon, Raj Naik, Fabrice R Lecuru et al. · 2025 · Cancers
Background: The surgical and medical management of recurrent ovarian cancer is complex and requires a personalized approach based on several factors, including the timing of recurrence, the patient’s performance status, previous treatment regimens, and the tumor’s histology and molecular characteristics. Objectives: Five randomized trials—GOG-0213, DESKTOP III, SOC 1, HORSE, and CHIPOR—have been conducted and shed light on our practice. Results: Both the DESKTOP III and the SOC 1 trials support the benefit of secondary surgery. The GOG-0213 trial, however, did not show an overall survival bene
View details →Negative / Null Result ReportOpen accessPsychology
Joaquin A. Anguera, Aleem Choudhry, Michael Seaman et al. · 2025 · JMIR Formative Research
Background There is evidence that cognitive training interventions can positively impact executive functions, and that some studies have demonstrated that athletes typically exhibit greater accuracy and faster response times on select cognitive tasks. While the engagement of executive functions is suggested to be part of high-level sporting activities, it is unclear whether such training approaches could directly benefit athletic performance. Objective The objective of this study was to evaluate the impact of a combined virtual reality (VR)– and tablet-based cognitive training intervention on
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Ruiyi Tian, Xiaoyu Zong, Duo Ren et al. · 2026 · Nature Medicine
Abstract Incidence of early-onset cancer is rising globally in recent generations, which underscores the need to elucidate the influence of emerging generational risk factors. Systemic and organ-specific aging reflects the cumulative impact of exposures and may provide an integrative and complementary approach to understand early-onset cancer risk. Here among 154,169 young adults from the United Kingdom Biobank, systemic aging measured by PhenoAge increased across birth cohorts, with 23% s.d. increase for those born 1965–1974 versus 1950–1954, and was associated with early-onset solid cancer r
View details →Replication FailureOpen accessMedicine
Mrudula Kanakapura Peramalaiah, Sanjay Tejraj Parmar, Nariman Sepehri et al. · 2025 · JMIR Rehabilitation and Assistive Technologies
BACKGROUND: Children with neurodevelopmental disorders, such as cerebral palsy (CP), often experience motor impairments in manual dexterity, which hinder daily tasks and social interactions. Traditional rehabilitation methods require repetitive task practice, which can be difficult for children to sustain due to low engagement. Game-based rehabilitation devices and robots offer a promising alternative by combining therapy with digital play, improving motivation and compliance. However, many systems fail to incorporate actual object manipulation, which is essential for motor learning through se
View details →Negative / Null Result ReportOpen accessMedicine
Thu Ha Dang, Nilmini S. Wickramasinghe, Prem Prakash Jayaraman et al. · 2024 · JMIR Formative Research
BACKGROUND: Medication nonadherence is a serious problem in cancer, potentially impacts patients' health outcomes and health care costs. Although technology-based medication adherence (MA) interventions have emerged, evidence supporting their quality and effectiveness remains limited. OBJECTIVE: This study tested the acceptability, feasibility, and potential effects of Safety and Adherence to Medications and Self-care Advice in Oncology (SAMSON), a digital solution designed to support MA and self-management in cancer. METHODS: A 12-week, 2-arm, unblinded, pragmatic pilot randomized controlled
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Luyanda Majenge, Sakhile Mpungose, Simiso Msomi · 2025 · Energies
The transition of South Africa from coal-dependent energy systems to renewable energy alternatives presents economic and environmental trade-off complexities that require empirical investigation. This study employed threshold-switching dynamic models, NARDL analysis, and threshold Granger causality tests to investigate nonlinear relationships between renewable energy generation, economic growth, and carbon dioxide emissions in South Africa from 1980 to 2023. The threshold-switching dynamic models revealed critical structural breakpoints: a 56.4% renewable energy threshold for carbon dioxide em
View details →Negative / Null Result ReportOpen accessMedicine
Sofia Asioli, Lidia Gatto, Uri Vardy et al. · 2024 · Cancers
Background: Glioblastoma IDH-wildtype (GBM IDH-wt) is the most aggressive brain tumor in adults and is characterized by an immunosuppressive microenvironment. Different factors shaping its tumor microenvironment (TME) regulate tumor progression and treatment response. The aim of this study was to characterize the main immunosuppressive elements of the GBM IDH-wt TME. Methods: Immunohistochemistry for CD3, CD4, CD8, CD163, programmed death ligand 1 (PD-L1) and programmed death 1 (PD1) was performed on surgical tumor specimens from patients diagnosed with GBM IDH-wt, according to the CNS WHO 202
View details →Negative / Null Result ReportOpen accessMedicine
Lion Stammen, Eva J I Hoeijmakers, Thomas G. Flohr et al. · 2025 · European Radiology
OBJECTIVES: To evaluate diagnostic image quality (IQ) for pulmonary embolism detection in photon-counting detector CT (PCD-CT) with significantly reduced contrast media (CM) dose vs conventional energy-integrating detector CT (EID-CT), using optimized and individualized CM protocols. MATERIALS AND METHODS: Consecutive CT pulmonary angiography (CTPA) scans performed on the EID-CT (Jan 2024-Mar 2024) with an individualized kilovoltage (kV) and total body weight (TBW) adapted CM protocol, and on the PCD-CT (Aug 2023-Feb 2024) with a TBW adapted CM protocol matching the 70 kV EID-CT protocol, were
View details →Negative / Null Result ReportOpen accessMedicine
Jijuan Zhang, Hancheng Yu, Tingting Geng et al. · 2025 · BMC Medicine
BACKGROUND: Accelerated aging is a dynamic process, yet few studies examined the association of changes in accelerated aging with cardiovascular disease (CVD) and mortality. This study aims to evaluate this association in three prospective…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Nurcan Kilinc‐Ata, Alia Al-Fori · 2026 · Journal of risk and financial management
The intersection of financial innovation and environmental sustainability offers important opportunities for low- and middle-income (LMI) countries. This study examines the association between FinTech investment, geopolitical-economic uncertainty, urbanization, economic development, and carbon dioxide (CO2) emissions in LMI countries. CO2 emissions per capita are used as an environmental outcome indicator rather than as a direct measure of green finance. Using a panel dataset covering 2010–2021, the study applies fixed-effects panel regressions as the main empirical approach and reports one-st
View details →Negative / Null Result ReportOpen accessMedicine
Ismail Gögenür, Tobias Freyberg Justesen, Line Schmidt Tarpgaard et al. · 2026 · Journal of Clinical Oncology
PURPOSE: Neoadjuvant immune checkpoint inhibition has shown promise in localized deficient mismatch repair (dMMR) colorectal cancer, yet the optimal treatment duration, regimen, and methods for response evaluation remain undefined. This trial aimed to investigate the efficacy and safety of neoadjuvant pembrolizumab for patients with localized dMMR colon cancer. METHODS: Participants received a single cycle of pembrolizumab (4 mg/kg, max 400 mg, every-6-weeks dosing regimen), followed by a preoperative endoscopy with biopsies and surgery 3-5 weeks later. The primary end point was pathologic com
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sourav Goswami, Alisha Ansari, Chetan Saraf et al. · 2026 · Nature Communications
Bifidobacteria are key health-associated members of the human gut microbiome and are widely used as probiotics, but their colonization success varies substantially between individuals, partly due to baseline microbiome composition. We…
View details →Negative / Null Result ReportOpen accessMedicine
Emanuel J. Novais, Olivia K. Ottone, Sanjana Jagannath et al. · 2026 · Bone Research
Genetic background is a major determinant of disc degeneration, a leading cause of chronic back pain and disability. Herein, we demonstrate that premature disc cell senescence contributes to early-onset degeneration in SM/J mice and test two systemic senotherapeutic strategies to mitigate it: Navitoclax (Nav.) and a cocktail of Dasatinib and Quercetin (DQ). While Nav. treatment did not improve severe degeneration in SM/J mice or senescence status, DQ-treated mice showed lower grades of degeneration and a decreased abundance of senescence markers, including p19ARF, p21, and the senescence-assoc
View details →Negative / Null Result ReportOpen accessMedicine
Danielle J Sisnett, Katherine B Zutautas, Dan Hoang Nguyet Vo et al. · 2026 · Frontiers in Immunology
Endometriosis is a chronic inflammatory, hormone dependent disorder that affects more than 200 million women worldwide. Immune dysfunction has emerged as one of the predominant mechanisms facilitating endometriosis lesion growth and survival. In particular, T cell subsets are predominant effector immune cells within the complex endometriosis lesion microenvironment. T cell biology encompasses a highly regulated and diverse network of cellular differentiation, antigen recognition, and immune regulation, all of which play critical roles in immune homeostasis. This complexity becomes particularly
View details →Replication FailureOpen accessMedicine
Nick Woznitza, Lesley Smith, Janette Rawlinson et al. · 2026 · Nature Medicine
Prioritizing artificial intelligence (AI)-detected imaging findings may reduce the time to diagnosis of lung cancer. This prospective, multicentre, randomized controlled trial tested whether immediate AI prioritization of primary care-requested chest X-rays (CXR) influenced time to computed tomography (CT) and lung cancer diagnosis, the primary outcomes. Secondary outcomes included the number of urgent suspected lung cancer referrals, incidence and stage of lung cancer, times to urgent referral and treatment, concordance between AI and radiology reports, and algorithm accuracy. AI was availabl
View details →Negative / Null Result Report
P. Sumithran, K. Purcell, S. Kuyruk et al. · 2017 · Clinical Obesity
Summary Consistent, strong predictors of obesity treatment outcomes have not been identified. It has been suggested that broadening the range of predictor variables examined may be valuable. We explored methods to predict outcomes of a…
View details →Negative / Null Result Report
Richard A. Gallenstein, John P. Dougherty · 2024 · American Journal of Agricultural Economics
Abstract Index insurance programs in developing countries have focused almost entirely on agricultural production risk (i.e., yield) while largely avoiding output marketing risk (i.e., price). This omission may miss an important constraint…
View details →Negative / Null Result Report
Guangming Chen, Xiaoyun Shan, Huabin Wang · 2021 · Nephrology
Abstract Aim Various studies have reported that urinary neutrophil gelatinase‐associated lipocalin (NGAL), an indicator of tubular damage, may be an effective biomarker of renal impairment in patients with diabetes. This study aimed to…
View details →Negative / Null Result Report
Jason West, Maiko Chu, Lincoln Crooks et al. · 2018 · Journal of Business Strategy
Purpose Business wargames represent an alternative approach to challenge organisations to uncover internal capabilities through competitive actions designed to counteract external threats and address strategic mismatches. Internal…
View details →Negative / Null Result Report
Dolores Ruiz-Lupión, Jordi Pascual, Nereida Melguizo-Ruiz et al. · 2019 · Insects
Soil fauna play a key role in nutrient cycling and decomposition, and in recent years, researchers have become more and more interested in this compartment of terrestrial ecosystems. In addition, soil fauna can act as ecosystem engineers…
View details →Negative / Null Result Report
Natsu Sasaki, Reiko Kuroda, Kanami Tsuno et al. · 2022 · Neuropsychopharmacology Reports
Abstract Objectives This study aimed to examine the effectiveness of vaccination to improve mental health among employees in Japan based on a prospective study. Methods The data were retrieved from the Employee Cohort Study conducted…
View details →Negative / Null Result Report
Anna Adamczak-Bugno, Aleksandra Krampikowska · 2020 · Materials
This article proposes to use the acoustic emission (AE) method to evaluate the degree of change in the mechanical parameters of fiber–cement boards. The research was undertaken after a literature review, due to the lack of a methodology…
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