21,247 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Rolando A. Rebolledo, Bo Liu, Mohammed Z. Akhtar et al. · 2015 · BioMed Research International
Effect of glucocorticoid administration on improving the outcomes of kidney and liver allografts has not been clearly elucidated. This study investigated the effect of prednisolone administration after onset of brain death (BD) on kidney…
View details →Mona Almalik, Alice Kiger, Janet Tucker · 2010 · International Journal of Qualitative Methods
Although a few researchers mention that involving interpreters can have an impact on the research process and research findings, little is published regarding methods of assessing the interpretation work's quality and impact. The impact of…
View details →Thomas Gerhard Wolf, Elena Baumgärtner, Burkhard Peter · 2022 · Frontiers in Psychology
Several publications with healthcare professionals, such as psychotherapists, have shown a significant difference in personality styles in practitioners using hypnosis compared to those not using hypnosis. To investigate differences in…
View details →Yui Matsuda, Todd A. Schwartz, YunKyung Chang et al. · 2019 · Journal of the American Psychiatric Nurses Association
BACKGROUND: Mothers’ depressive symptoms affect their children’s growth as well as physical and mental well-being. Moreover, mothers of young children with developmental delay or disability (DD) tend to have higher depressive symptoms.…
View details →Natsu Sasaki, Reiko Kuroda, Kanami Tsuno et al. · 2022 · Neuropsychopharmacology Reports
Abstract Objectives This study aimed to examine the effectiveness of vaccination to improve mental health among employees in Japan based on a prospective study. Methods The data were retrieved from the Employee Cohort Study conducted…
View details →Guangming Chen, Xiaoyun Shan, Huabin Wang · 2021 · Nephrology
Abstract Aim Various studies have reported that urinary neutrophil gelatinase‐associated lipocalin (NGAL), an indicator of tubular damage, may be an effective biomarker of renal impairment in patients with diabetes. This study aimed to…
View details →Qun Xiao, WeiCheng Huang, Yuheng Zhuang et al. · 2025 · Aging Clinical and Experimental Research
BACKGROUND: Stroke is a significant public health issue, with its risk influenced by various metabolic factors. The Cholesterol, High-Density Lipoprotein, Glucose (CHG) index has been identified as a valid stroke predictor. However, the…
View details →Rafael Cabral, Ricardo Santos, José A.F.O. Correia et al. · 2025 · Sensors
The automated inspection of civil infrastructure with Unmanned Aerial Vehicles (UAVs) is hampered by the challenge of accurately segmenting multi-damage in high-resolution imagery. While foundational models like the Segment Anything Model (SAM) offer data-efficient segmentation, their effectiveness is constrained by prompting strategies, especially for geometrically complex defects. This paper presents a comprehensive comparative analysis of deep learning strategies to identify an optimal deep learning pipeline for segmenting cracks, efflorescences, and exposed rebars. It systematically evalua
View details →Andrea Espis, Chiara Marzi, Stefano Diciotti · 2025 · Scientific Reports
Self-supervised learning (SSL) in computer vision has shown its potential to reduce reliance on labeled data. However, most studies focused on balanced, large, broad-domain datasets like ImageNet, whereas, in real-world medical applications, dataset size is typically limited. This study compares the performance of SSL versus supervised learning (SL) on small, imbalanced medical imaging datasets. We experimented with four binary classification tasks: age prediction and diagnosis of Alzheimer's disease from brain magnetic resonance imaging scans, pneumonia from chest radiograms, and retinal dise
View details →Manav Raj, Justin M. Berg, Rob Seamans · 2026 · Journal of Experimental Psychology General
= 27,491), we examine how evaluations of creative writing are affected by whether participants believe the content is produced with an AI model. We find consistent evidence of an AI disclosure penalty: Participant evaluations of creative…
View details →Mateja Napravnik, Franko Hržić, Martin Urschler et al. · 2025 · Scientific Reports
Deep learning models require large amounts of annotated data, which are hard to obtain in the medical field, as the annotation process is laborious and depends on expert knowledge. This data scarcity hinders a model's ability to generalise…
View details →M. Said Doğru, Emily Faulconer · 2025 · Research in Science Education
Abstract The emergence of ChatGPT brings an opportunity to lighten the workload of in-person teaching assistance in science laboratory courses. We investigated the use of the language model developed by OpenAI as a virtual teaching assistant for an introductory undergraduate biology laboratory course. Student-generated questions related to a laboratory exercise on enzyme activity were separately provided to ChatGPT and a cohort of graduate teaching assistants (TAs). Responses were evaluated for content accuracy and teaching effectiveness. Results revealed that human TAs were more accurate in t
View details →Nina Boskovic, Marilin Ivask, Gamze Yazgeldi Gunaydin et al. · 2025 · Scientific Reports
Abstract Mammalian preimplantation embryo development is a complex sequence of events. This period of development is sensitive to oxygen (O 2 ) levels that can affect various cellular processes. We compared the influence of O 2 tension by culturing embryos either in normoxic (20% O 2 ) or physiological hypoxic (6% O 2 ) conditions, or sequential low O 2 concentration starting with 6% O 2 until 16-cell stage and then switching to ultrahypoxic conditions (2% O 2 ). Due to ethical concerns, we used bovine as an animal model with a good similarity of embryogenesis to human. We found that the cleav
View details →Paul Behrens, Catherine M. Champagne, Jason C. G. Halford et al. · 2025 · Frontiers in Science
The global obesity crisis involves an unprecedented and rapid change to the human phenotype. Conferring vast levels of avoidable morbidity and mortality at enormous cost, it has proved refractory to previous policy-led action. This article reviews recent developments in our understanding of obesity and its links to the climate co-crisis, aiming to inform evidence-based, societal-level actions to address both. Recent therapeutic developments now offer transformative interventions for millions of people living with obesity. However, treating all affected adults and children with major bariatric
View details →Orkhan Ibrahimov, László Vancsura, Anett Parádi-Dolgos · 2025 · Economies
Measuring financial performance is pivotal not only for assessing a firm’s current health but also for informing strategic decisions that shape its long-term trajectory. This study investigates how macroeconomic volatility affects the firm profitability across five major sectors in Türkiye—industrial manufacturing, food, beverage and tobacco, chemicals and plastics, technology, and energy—during the turbulent period from 2016 to 2023. Using return on assets (ROA) and return on equity (ROE) as performance indicators, we apply panel data regression to test the impact of inflation, interest rates
View details →Amir Nasrolahi Shirazi, Rajesh Vadlapatla, Ajoy Koomer et al. · 2025 · Pharmaceutics
Selenium nanoparticles (SeNPs) have emerged as promising metal-based nanoparticles for drug delivery due to their unique physicochemical properties, intrinsic bioactivity, and biocompatibility. SeNPs offer a lower toxicity, higher bioavailability, and flexibility to be customized for surface chemistry compared to traditional selenium compounds. Advances in synthetic strategies, including chemical reduction, green biosynthesis, and surface functionalization with polymers, peptides, or ligands, have improved their stability, targeting capability, and circulation time. SeNP-based systems have dem
View details →Lucie E. Rowland, Mauro Stefanon, R. J. Bouwens et al. · 2026 · Monthly Notices of the Royal Astronomical Society
ABSTRACT Metallicity is a crucial tracer of galaxy evolution, providing insights into gas accretion, star formation, and feedback. At high redshift, these processes reveal how early galaxies assembled and enriched their interstellar medium. In this work, we present rest-frame optical spectroscopy of 12 massive ($\log (M_*/\mathrm{{\rm M}_{\odot }})>9$) galaxies at $z\sim 6$–8 from the Reionization Era Bright Emission Line Survey (REBELS) Atacama Large Millimetre/submillimetre Array (ALMA) large program, observed with the James Webb Space Telescope (JWST) NIRSpec integral field unit spec
View details →Dayoung Seo, Yangsean Choi, Eunseon Jeong et al. · 2025 · Nature Communications
Although brain alterations have been reported in post-acute sequelae of SARS-CoV-2 (PASC), their prevalence and relationship to neurodegeneration remain unclear. We analyzed blood proteins and brain MRI from individuals approximately one…
View details →Matěj Opatrný, Tomáš Havránek, Zuzana Iršová et al. · 2025 · Journal of Labor Economics
Class size reduction mandates are frequent and invariably justified by studies reporting positive effects on student achievement. Yet other studies report no effects, and the literature as a whole awaits correction for potential…
View details →Joanna M Porter, Cici Jin, Michael Churchman et al. · 2025 · European Journal of Cancer
BACKGROUND: Antibody-drug conjugates (ADCs) are emerging anti-cancer agents. The folate receptor alpha (FOLRα)-directed ADC mirvetuximab soravtansine recently demonstrated clinical activity in platinum-resistant ovarian cancer, with other ADCs currently in development. The relative expression of FOLRα and other ADC targets is largely unknown across ovarian cancer histotypes. METHODS: Expression levels of the ADC targets FOLRα, TROP2 and B7-H4 were assessed by immunohistochemistry in patient cohorts using tumour tissue microarrays of the major ovarian cancer histotypes: high grade serous (HGSOC
View details →Robert W. Lentz, Tyler J. Friedrich, Patrick J. Blatchford et al. · 2024 · Clinical Cancer Research
PURPOSE: In this single-institution phase II investigator-initiated study, we assessed the ability of MAPK and VEGF pathway blockade to overcome resistance to immunotherapy in microsatellite-stable metastatic colorectal cancer (MSS mCRC).…
View details →J. Jithish, Nagarajan Mahalingam, Bo Wang et al. · 2025 · Cybersecurity
Abstract The forthcoming 6G technology offers significant potential for the advancement of the smart grid domain. 6G promises ultra-low latency, higher data transfer rates, native Artificial Intelligence (AI) support, enhanced connectivity, and improved security for smart grids. Smart grids are vulnerable to cyberattacks, such as Distributed Denial-of-Service (DDoS) attacks, posing a significant threat to grid functionality. To address security concerns, smart grids implement intrusion detection systems (IDS), but detecting novel attacks such as subtle multi-domain DDoS attacks through traditi
View details →Jason Smith, Rebecca Cardigan, Emily Sanderson et al. · 2026 · New England Journal of Medicine
BACKGROUND: Whole-blood transfusion has recently gained favor in the management of severe hemorrhage; however, data from large clinical trials evaluating its clinical effectiveness and safety are lacking. METHODS: We conducted a pragmatic,…
View details →Noor Wortelboer, Annemiek van Ommen-Nijhof, Inge R. Konings et al. · 2026 · JAMA Oncology
Importance: Cyclin-dependent kinase (CDK) 4 and 6 inhibitors (CDK4/6i) combined with endocrine therapy are widely used in hormone receptor (HR)-positive, ERBB2-negative advanced breast cancer (ABC). The SONIA trial evaluates the optimal…
View details →Fiyinfoluwa Demilade Ojeniyi, Adeola Oluwakemi Ayoola, Olajumoke Ibitoye et al. · 2025 · Scientific Reports
Rapid diagnostic tests (RDTs) have revolutionized malaria diagnosis, playing a crucial role in improving timely treatment and supporting surveillance efforts, especially in resource-limited settings. However, the performance of RDTs can…
View details →Rafael Scaf de Molon, João Paulo Steffens, Érica Dorigatti de Ávila et al. · 2026 · Journal of Periodontal Research
Periodontitis is a chronic, host-mediated inflammatory disease in which microbial dysbiosis and dysregulated immune responses drive the destruction of tooth-supporting tissues. Although conventional therapy remains centered on mechanical biofilm control, persistent inflammation and alveolar bone loss in susceptible individuals underscore the need for adjunctive strategies. Translating preclinical discoveries into predictable clinical outcomes, however, remains a major challenge in periodontal research. This narrative review integrates two interrelated themes, translational research methodology
View details →F Visalli, Matteo Capobianco, F. Cappellani et al. · 2026 · International Journal of Molecular Sciences
Mitochondrial dysfunction represents a central hallmark of aging and a broad spectrum of chronic diseases, ranging from metabolic to neurodegenerative and ocular disorders. Nicotinamide riboside (NR), a vitamin B3 derivative and efficient precursor of NAD+ (nicotinamide adenine dinucleotide), and berberine (BBR), an isoquinoline alkaloid widely investigated in metabolic regulation, have independently emerged as promising mitochondrial modulators. NR enhances cellular NAD+ pools, thereby activating sirtuin-dependent pathways, stimulating PGC-1α–mediated mitochondrial biogenesis, and triggering
View details →Guangxiang Liu, Md Kamal Hossain · 2026 · Journal of Computer Assisted Learning
ABSTRACT Background Amid Bangladesh's national efforts to enhance digital inclusion, rural university students continue to face persistent infrastructural and educational inequalities that limit their access to quality English learning…
View details →Rachel O’Neill · 2025 · International Journal of Cultural Studies
Medical doctors are central to existing networks for wellness content on Instagram in and beyond the UK, yet remain overlooked within scholarship concerned with this terrain. Taking a case study approach, this article examines three such figures prominent in the UK context. In doing so, it challenges existing conceptualisations of the 'wellness influencer' and argues for an expanded understanding of the category, one that does not assume its representatives are 'lay' persons without recognised expertise in health and well-being. The analysis developed demonstrates that credentials cannot resol
View details →Valdemar Brimnes Ingemann Johansen, Anna Katrina Jógvansdóttir Gradel, Stephanie Kjærulff Holm et al. · 2025 · Cell Reports Medicine
Liver-expressed antimicrobial peptide 2 (LEAP2) is an endogenous antagonist and inverse agonist of the ghrelin receptor, countering ghrelin's effects on cell signaling and feeding. However, despite an emerging interest in LEAP2's…
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