Negative / Null Result Report
Ian I. Courter, Tom Chance, Ryan Gerstenberger et al. · 2022 · Canadian Journal of Fisheries and Aquatic Sciences
For over 150 years, hatchery-origin anadromous salmon and trout have been reared and released throughout the Pacific Northwest to mitigate for lost habitat and sustain harvest opportunity. Some studies demonstrate that introgression of…
View details →Negative / Null Result ReportOpen accessMedicine
Joanne H. Reed, Gwenny M. Verstappen, Maureen Rischmueller et al. · 2020 · PubMed
Primary Sjögren's syndrome (pSS) is often considered a B cell-mediated disease, yet the precise role of B cells in the pathogenesis is not fully understood. This is exemplified by the failure of multiple clinical trials directed at B cell…
View details →Negative / Null Result ReportOpen accessMedicine
Chandran Ramakrishna, Mari S. Golub, Abby J. Chiang et al. · 2017 · Behavioural Neurology
Herpes simplex virus 1 (HSV) encephalitis (HSE) has serious neurological complications, involving behavioral and cognitive impairments that cause significant morbidity and a reduced quality of life. We showed that HSE results from dysregulated central nervous system (CNS) inflammatory responses. We hypothesized that CNS inflammation is casually involved in behavioral abnormalities after HSE and that treatment with ACV and pooled human immunoglobulin (IVIG), an immunomodulatory drug, would improve outcomes compared to mice treated with phosphate buffered saline (PBS) or ACV alone. Anxiety level
View details →Negative / Null Result ReportOpen accessMedicine
Martin S. Weber, Jacqueline Nicholas, Michael R. Yeaman · 2021 · Neurology Neuroimmunology & Neuroinflammation
Bruton tyrosine kinase inhibitors (BTKis) encompass a new class of therapeutics currently being evaluated for the treatment of multiple sclerosis (MS). Whether BTKis affect COVID-19 risk or severity or reduce vaccine efficacy are important…
View details →Negative / Null Result ReportOpen accessMedicine
Mahima Chillakanti, Elaine Young, April Hopcroft et al. · 2024 · touchREVIEWS in Endocrinology
AID systems can achieve near-desired glycaemic targets with minimal hypoglycaemia in pregnant women with T1D. Randomized controlled trials are needed to confirm these findings and to win FDA indications in pregnancy.
View details →Negative / Null Result ReportOpen accessMedicine
Silvia Park, Emma Langley, Jong‐Mu Sun et al. · 2015 · Oncotarget
// Silvia Park 1, * , Emma Langley 2, * , Jong-Mu Sun 1 , Steve Lockton 2 , Jin Seok Ahn 1 , Anjali Jain 2 , Keunchil Park 1 , Sharat Singh 2 , Phillip Kim 2 , Myung-Ju Ahn 1 1 Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 2 Prometheus Laboratories Inc, A Nestlé Health Science Company, Department of Research and Development, San Diego, CA, USA * These authors have contributed equally to this work Correspondence to: Myung-Ju Ahn, e-mail: silkahn@skku.edu Phillip Kim, e-mail: pkim@prometheuslabs.co
View details →Negative / Null Result ReportOpen accessMedicine
Ciara Conduit, Ian D. Davis, Jeffrey C. Goh et al. · 2023 · British Journal of Urology
OBJECTIVE: To evaluate the efficacy of sequential treatment with ipilimumab and nivolumab following progression on nivolumab monotherapy in individuals with advanced, non-clear-cell renal cell carcinoma (nccRCC). MATERIALS AND METHODS:…
View details →Replication FailureOpen accessImmunology and Microbiology
Tomoki Makino, Hiroshi Miyata, Takushi Yasuda et al. · 2024 · Esophagus
BACKGROUND: S-588410, a cancer peptide vaccine (CPV), comprises five HLA-A*24:02-restricted peptides from five cancer-testis antigens. In a phase 2 study, S-588410 was well-tolerated and exhibited antitumor efficacy in patients with urothelial cancer. Therefore, we aimed to evaluate the efficacy, immune response, and safety of S-588410 in patients with completely resected esophageal squamous cell carcinoma (ESCC). METHODS: This phase 3 study involved patients with HLA-A*24:02-positive and lymph node metastasis-positive ESCC who received neoadjuvant therapy followed by curative resection. After
View details →Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Michal Mego, Barbora Judita Kasperová, Jozef Chovanec et al. · 2024 · Frontiers in Oncology
Background: Probiotics could decrease irinotecan-induced diarrhea due to the reduction of intestinal beta-d-glucuronidase activity. This study included a combined analysis of two clinical trials aimed to determine the effectiveness of the probiotics in the prophylaxis of irinotecan-induced diarrhea in metastatic colorectal cancer (CRC) patients. Methods: This combined analysis included 46 patients with CRC enrolled in the Probio-SK-003 (NCT01410955) and 233 patients from Probio-SK-005 (NCT02819960) starting a new line of irinotecan-based therapy with identical eligibility criteria. Patients we
View details →Negative / Null Result ReportOpen accessMedicine
Lien Anh Ha Do, Zheng Quan Toh, Paul Vincent Licciardi et al. · 2021 · The Lancet Global Health
Measles virus and respiratory syncytial virus (RSV) are two important global health pathogens causing substantial morbidity and mortality worldwide. The current measles vaccination schedule has the first dose given at 9-12 months of age…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Zhongwei Liu, Shuang Shi, Haitao Zhu et al. · 2018 · International Heart Journal
The phenotype shifting of vascular smooth muscle cells (VSMCs) was indicated to play a role during the initial stage of atherosclerotic plaque formation by facilitating extracellular matrix deposition. This study was aimed at investigating…
View details →Negative / Null Result ReportOpen accessMedicine
Adrian K. Davison, Ashma Krishan, Robert P New et al. · 2024 · Lara D. Veeken
OBJECTIVES: To test the hypothesis that photographs (in addition to self-reported data) can be collected daily by patients with SSc using a smartphone app designed specifically for digital lesions, and could provide an objective outcome measure for use in clinical trials. METHODS: An app was developed to collect images and patient-reported outcome measures including Pain score and the Hand Disability in Systemic Sclerosis-Digital Ulcers (HDISS-DU) questionnaire. Participants photographed their lesion(s) each day for 30 days and uploaded images to a secure repository. Lesions were analysed both
View details →Negative / Null Result ReportOpen accessMedicine
Shiho Arima, Kyoko Shimizu, Tomoyoshi Okamoto et al. · 2017 · Anticancer Research
BACKGROUND: Gemcitabine (GEM) plus cisplatin (CDDP) chemotherapy has been used worldwide as the standard first-line treatment for advanced biliary tract cancer (BTC). A phase II trial has also suggested promising activity of GEM plus S-1…
View details →Negative / Null Result ReportOpen accessMedicine
Xiao Xuan Xing, Chen Zhu, Yan Chu et al. · 2021 · BMC Gastroenterology
BACKGROUND: Perioperative patients are at risk of developing stress ulcers (SU), which can cause clinically important bleeding. Stress ulcer prophylaxis (SUP) is widely applied to the patients in Intensive care unit (ICU) as well as the general ward, so it may lead to overmedication. However, there have been no surveys regarding SUP knowledge or prescribing habits. OBJECTIVE: Our study assessed the knowledge, attitudes, and prescribing behavior of the surgeons toward perioperative patients regarding SUP and determined factors associated with low knowledge and high level of prescribing behavior
View details →Negative / Null Result ReportOpen accessImmunology and Microbiology
Shih-Hong Chen, Wing-Sum Chan, Chih‐Min Liu et al. · 2020 · Annals of Intensive Care
Abstract Background Endotoxins can induce an excessive inflammatory response and result in microcirculatory dysfunction. Polymyxin-B hemoperfusion (PMX-HP) has been recognized to effectively remove endotoxins in patients with sepsis and…
View details →Negative / Null Result ReportOpen accessEngineering
Yudan Wang, Litian Liu, Xinning Li et al. · 2022 · Journal of Interventional Cardiology
Background: Mortality after percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction (STEMI) patients with cardiogenic shock (CS) remains high. However, the real-world risk factors for mortality in these patients are poorly defined. Objective: The aim of this study is to establish a clinical prognostic nomogram for predicting in-hospital mortality after primary PCI in STEMI patients with CS. Methods: This retrospective, multicenter, observational study included STEMI patients with CS who underwent PCI at 39 hospitals in Hebei Province from January 2018 to December 2019. A
View details →Negative / Null Result ReportOpen accessMedicine
Kazuhiro Yamamoto · 2017 · Yonago acta medica
Heart failure with preserved ejection fraction is a socioeconomic burden in Japan as well as other developed countries. Diuretics are widely used to attenuate symptoms and signs of congestion in both heart failure with preserved and…
View details →Negative / Null Result ReportOpen accessMedicine
İpek Komşuoğlu Çelikyurt · 2011 · Pharmaceutica Analytica Acta
Affirmative influence of antioxidant vitamins may be observed in atherosclerosis and endothelial dysfunction, male infertility, Parkinson's disease (especially via lipoic acid), diabetes, brain tumors and skin maturation There is not yet…
View details →Negative / Null Result ReportOpen accessMedicine
Qiang Tang, Yanwei Liu, Yingfeng Fu et al. · 2021 · Scientific Reports
The 2019 Coronavirus Disease (COVID-19) has become an unprecedented public crisis. We retrospectively investigated the clinical data of 197 COVID-19 patients and identified 88 patients as disease aggravation cases. Compared with patients without disease aggravation, the aggravation cases had more comorbidities, including hypertension (25.9%) and diabetes (20.8%), and presented with dyspnoea (23.4%), neutrophilia (31.5%), and lymphocytopenia (46.7%). These patients were more prone to develop organ damage in liver, kidney, and heart (P < 0.05). A multivariable regression analysis showed that adv
View details →Negative / Null Result ReportOpen accessMedicine
Zachary Veitch, Alona Zer, Herbert H. Loong et al. · 2019 · Scientific Reports
ENMD-2076, an aurora-A kinase inhibitor with anti-angiogenic properties, has shown activity in solid and hematologic malignancies. We investigated oral ENMD-2076 in an open-label, single-arm phase II study using 275 mg daily on a 28-day cycle in patients with advanced soft-tissue sarcomas (STS) receiving ≤1 line of prior therapy. Primary endpoint was 6-month progression-free survival (PFS) with ≤15% indicating no interest, and ≥40% indicating further interest in ENMD-2076. Secondary/exploratory endpoints included clinical benefit (CBR ≥6-months) and objective response (ORR) rates, PFS, OS, saf
View details →Negative / Null Result ReportMedicine
Mao Uematsu, Yoko Tsukita, Takehiro Tozuka et al. · 2023 · Journal of Clinical Oncology
9012 Background: Immune checkpoint inhibitor (ICI) plus chemotherapy is now a standard treatment for non-small cell lung cancer (NSCLC) without targetable oncogene alternations. However, the efficacy and safety of ICI plus chemotherapy…
View details →Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Sukeshi Patel Arora, Laura Tenner, John Sarantopoulos et al. · 2019 · Journal of Clinical Oncology
3551 Background: Agents targeting the angiogenic pathway have been a cornerstone therapy in mCRC. In chemo-refractory mCRC, RGF, an oral multikinase inhibitor with considerable angiogenic inhibition, has shown modest effects on survival.…
View details →Negative / Null Result ReportOpen accessMedicine
Maya Gopalakrishnan, Satyendra Khichar, Suman Saurabh et al. · 2022 · Monaldi Archives for Chest Disease
Awake self-proning is being used widely as respiratory support in COVID-19 hypoxemia, in resource-limited settings. We aimed to investigate the effectiveness of early awake self-proning in preventing mortality and the need for intubation…
View details →Negative / Null Result ReportOpen accessMedicine
Sean Haimowitz, David Cohen, Aatin K. Dhanda et al. · 2022 · The Laryngoscope
OBJECTIVES: Mucosal melanoma (MM) is a rare malignancy that can present in the head and neck (H&N). The Oral cavity is the second most common primary site in the H&N after sinonasal mucosa. This study investigates the impact of demographic…
View details →Negative / Null Result ReportMedicine
Andrew Goudie, Douglas H.J. Elder, Harshal Deshmukh et al. · 2014 · European Journal of Heart Failure
BACKGROUND: The use of oral anticoagulation in patients with heart failure in sinus rhythm remains controversial as previous large randomized controlled trials (RCTs) have not shown a survival benefit. However, heterogeneity exists among…
View details →Negative / Null Result ReportMedicine
Sidsel Pedersen, Søren Møller, Marco Donia et al. · 2022 · Melanoma Research
Novel medical therapies have revolutionized outcome for patients with melanoma. However, patients with melanoma brain metastases (MBM) still have poor survival. Data are limited as these patients are generally excluded from clinical…
View details →Negative / Null Result ReportOpen accessMedicine
Fangzheng Wang, Jiang Chuner, Quanquan Sun et al. · 2018 · Journal of Cancer
In this study, we examined whether combining neoadjuvant chemotherapy (NAC) and/or concurrent chemotherapy (CC) with intensity-modulated radiotherapy (IMRT) improved survival in patients with stage II nasopharyngeal carcinoma (NPC). Two hundred forty-two stage II NPC patients were enrolled between May 2008 and April 2014 and received radical IMRT with simultaneous integrated boost technique using 6 MV photons; some patient groups also received chemotherapy every 3 weeks for 2-3 cycles. The median follow-up duration was 69 months for all patients. At the last follow-up, 18 patients had experien
View details →Negative / Null Result Report
R Karkee · 2012 · Journal of Nepal Medical Association
Nepal reportedly reduced the maternal mortality ratio by 48% within one decade between 1996-2005 and received the Millennium development goal award for this. However, there is debate regarding the accuracy of this figure. On the basis of…
View details →Negative / Null Result Report
Ananda Chairunnisa, Zuliani Dalimunthe · 2021 · Jurnal Akuntansi dan Keuangan
In Indonesia's capital market, there was a phenomenon that famous influencers seem to lead to behavioral bias in the stock market. The stock price changed significantly after those stock influencers shared information or recommended…
View details →Negative / Null Result ReportMedicine
Anne Debost‐Legrand, Lemlih Ouchchane, Christine Francannet et al. · 2015 · Birth Defects Research Part A Clinical and Molecular Teratology
BACKGROUND: Transposition of great arteries (TGA) defined as the combination of concordant atrioventricular and discordant ventriculo-arterial connections is one of the most common congenital heart defects. Prenatal diagnosis of TGA…
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