Modulation of autophagy: A phase II study of vorinostat (VOR) plus hydroxychloroquine (HCQ) vs regorafenib (RGF) in chemo-refractory metastatic colorectal cancer (mCRC).
Sukeshi Patel Arora; Laura Tenner; John Sarantopoulos; Jay Morris; Lisa Longoria; Qianqian Liu; Joel Michalek; Devalingam Mahalingam · 2019 · Journal of Clinical Oncology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
3551 Background: Agents targeting the angiogenic pathway have been a cornerstone therapy in mCRC. In chemo-refractory mCRC, RGF, an oral multikinase inhibitor with considerable angiogenic inhibition, has shown modest effects on survival.…
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Metadata source: OpenAlex · DOI 10.1200/jco.2019.37.15_suppl.3551