A phase 3, randomized, double-blind, multicenter, placebo-controlled study of S-588410, a five-peptide cancer vaccine as an adjuvant therapy after curative resection in patients with esophageal squamous cell carcinoma
Tomoki Makino; Hiroshi Miyata; Takushi Yasuda; Yuko Kitagawa; Kei Muro; Jae-Hyun Park; Tetsuro Hikichi; Takahiro Hasegawa · 2024 · Esophagus
WASTE classifies this as Replication Failure · AI classification, approximate
A previously reported effect did not replicate here — verify it holds before you build on it.
Abstract
BACKGROUND: S-588410, a cancer peptide vaccine (CPV), comprises five HLA-A*24:02-restricted peptides from five cancer-testis antigens. In a phase 2 study, S-588410 was well-tolerated and exhibited antitumor efficacy in patients with urothelial cancer. Therefore, we aimed to evaluate the efficacy, immune response, and safety of S-588410 in patients with completely resected esophageal squamous cell carcinoma (ESCC). METHODS: This phase 3 study involved patients with HLA-A*24:02-positive and lymph node metastasis-positive ESCC who received neoadjuvant therapy followed by curative resection. After
Abstract by Tomoki Makino; Hiroshi Miyata; Takushi Yasuda; Yuko Kitagawa; Kei Muro; Jae-Hyun Park; Tetsuro Hikichi; Takahiro Hasegawa, Esophagus (2024) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1007/s10388-024-01072-w