Growth directions and stiffness across cell layers determine whether tissues stay smooth or buckle
Avilash Singh Yadav; Lilan Hong; Patrick M. Klees; Annamária Kiss; Manuel Petit; Xi He; Iselle M. Barrios; Michelle Heeney · 2026 · Current Biology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Nature exhibits organs of various shapes and forms, ranging from smooth to undulated morphologies. How cells coordinate their growth to produce smoothly shaped leaves and leaf-like organs such as sepals remains unclear. We identified a mutant, as2-7D, that exhibits ectopic expression of ASYMMETRIC LEAVES 2 (AS2) on the outer epidermis. Our analysis reveals that ectopic AS2 expression causes the outer epidermis of as2-7D sepals to buckle during early stages of sepal development. Buckling is caused by conflicting cell growth directions and unequal tissue stiffness across the epidermal layers. Ov
Abstract by Avilash Singh Yadav; Lilan Hong; Patrick M. Klees; Annamária Kiss; Manuel Petit; Xi He; Iselle M. Barrios; Michelle Heeney, Current Biology (2026) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1016/j.cub.2026.08.011