Negative / Null Result ReportOpen accessPsychology
Catherine Hobaiter, Timothée Poisot, Klaus Zuberbühler et al. · 2014 · PLoS Biology
Social network analysis methods have made it possible to test whether novel behaviors in animals spread through individual or social learning. To date, however, social network analysis of wild populations has been limited to static models that cannot precisely reflect the dynamics of learning, for instance, the impact of multiple observations across time. Here, we present a novel dynamic version of network analysis that is capable of capturing temporal aspects of acquisition--that is, how successive observations by an individual influence its acquisition of the novel behavior. We apply this mo
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Amy R. Romijn, Julia J. Rucklidge, Roeline G. Kuijer et al. · 2017 · Australian & New Zealand Journal of Psychiatry
OBJECTIVES: This trial investigated whether probiotics improved mood, stress and anxiety in a sample selected for low mood. We also tested whether the presence or severity of irritable bowel syndrome symptoms, and levels of proinflammatory…
View details →Negative / Null Result ReportOpen accessMedicine
The INIS Collaborative Group · 2011 · New England Journal of Medicine
BACKGROUND: Neonatal sepsis is a major cause of death and complications despite antibiotic treatment. Effective adjunctive treatments are needed. Newborn infants are relatively deficient in endogenous immunoglobulin. Meta-analyses of…
View details →Negative / Null Result ReportOpen accessMedicine
Jane Warwick, Emanuela Falaschetti, Kenneth Rockwood et al. · 2015 · BMC Medicine
BACKGROUND: Treatment for hypertension with antihypertensive medication has been shown to reduce stroke, cardiovascular events, and mortality in older adults, but there is concern that such treatment may not be appropriate in frailer older adults. To investigate whether there is an interaction between effect of treatment for hypertension and frailty in older adults, we calculated the frailty index (FI) for all available participants from the HYpertension in the Very Elderly Trial (HYVET) study, a double-blind, placebo-controlled study of antihypertensives in people with hypertension aged 80 an
View details →Negative / Null Result ReportOpen accessHealth Professions
US Preventive Services Task Force, David C. Grossman, Susan J. Curry et al. · 2018 · JAMA
Importance: Falls are the leading cause of injury-related morbidity and mortality among older adults in the United States. In 2014, 28.7% of community-dwelling adults 65 years or older reported falling, resulting in 29 million falls (37.5%…
View details →Negative / Null Result ReportMedicine
William G. Lindsley, Terri Pearce, Judith B. Hudnall et al. · 2012 · Journal of Occupational and Environmental Hygiene
The question of whether influenza is transmitted to a significant degree by aerosols remains controversial, in part, because little is known about the quantity and size of potentially infectious airborne particles produced by people with…
View details →Negative / Null Result ReportSocial Sciences
Nazanin Andalibi, Pinar Ozturk, Andrea Forte · 2017
People can benefit from disclosing negative emotions or stigmatized facets of their identities, and psychologists have noted that imagery can be an effective medium for expressing difficult emotions. Social network sites like Instagram…
View details →Negative / Null Result ReportOpen accessEnergy
Ramadan J. Mustafa, Mohamed R. Gomaa, Mujahed Al‐Dhaifallah et al. · 2020 · Sustainability
This study scrutinizes the reliability and validity of existing analyses that focus on the impact of various environmental factors on a photovoltaic (PV) system’s performance. For the first time, four environmental factors (the accumulation of dust, water droplets, birds’ droppings, and partial shading conditions) affecting system performance are investigated, simultaneously, in one study. The results obtained from this investigation demonstrate that the accumulation of dust, shading, and bird fouling has a significant effect on PV current and voltage, and consequently, the harvested PV energy
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Mitchell T. Butler, Qingfeng Wang, Rasika M. Harshey · 2010 · Proceedings of the National Academy of Sciences
Swarming bacteria move in multicellular groups and exhibit adaptive resistance to multiple antibiotics. Analysis of this phenomenon has revealed the protective power of high cell densities to withstand exposure to otherwise lethal…
View details →Negative / Null Result ReportOpen accessMedicine
Mihai Gheorghiade, Michael Böhm, Stephen J. Greene et al. · 2013 · JAMA
IMPORTANCE: Hospitalizations for heart failure (HHF) represent a major health burden, with high rates of early postdischarge rehospitalization and mortality. OBJECTIVE: To investigate whether aliskiren, a direct renin inhibitor, when added…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Reid Tingley, Marcelo Vallinoto, Fernando Sequeira et al. · 2014 · Proceedings of the National Academy of Sciences
Accurate forecasts of biological invasions are crucial for managing invasion risk but are hampered by niche shifts resulting from evolved environmental tolerances (fundamental niche shifts) or the presence of novel biotic and abiotic…
View details →Negative / Null Result ReportEconomics, Econometrics and Finance
Thomas P. Lyon, Haitao Yin · 2010 · The Energy Journal
Renewable portfolio standards (RPSs) for electricity generation are politically popular in many U.S. states although economic analysis suggests they are not first-best policies. We present an empirical analysis of the political and…
View details →Negative / Null Result ReportOpen accessMedicine
Yan Wang, Fabiana Quagliarini, Viktoria Gusarova et al. · 2013 · Proceedings of the National Academy of Sciences
Angiopoietin-like protein (ANGPTL)8 (alternatively called TD26, RIFL, Lipasin, and Betatrophin) is a newly recognized ANGPTL family member that has been implicated in both triglyceride (TG) and glucose metabolism. Hepatic overexpression of…
View details →Negative / Null Result ReportOpen accessMedicine
Alice G. Cheng, Molly McAdow, Hwan Keun Kim et al. · 2010 · PLoS Pathogens
The bacterial pathogen Staphylococcus aureus seeds abscesses in host tissues to replicate at the center of these lesions, protected from host immune cells via a pseudocapsule. Using histochemical staining, we identified prothrombin and fibrin within abscesses and pseudocapsules. S. aureus secretes two clotting factors, coagulase (Coa) and von Willebrand factor binding protein (vWbp). We report here that Coa and vWbp together are required for the formation of abscesses. Coa and vWbp promote the non-proteolytic activation of prothrombin and cleavage of fibrinogen, reactions that are inhibited wi
View details →Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Carlos Serrano‐Cinca, Begoña Gutiérrez Nieto, Luz López-Palacios · 2015 · PLoS ONE
This paper studies P2P lending and the factors explaining loan default. This is an important issue because in P2P lending individual investors bear the credit risk, instead of financial institutions, which are experts in dealing with this risk. P2P lenders suffer a severe problem of information asymmetry, because they are at a disadvantage facing the borrower. For this reason, P2P lending sites provide potential lenders with information about borrowers and their loan purpose. They also assign a grade to each loan. The empirical study is based on loans' data collected from Lending Club (N = 24,
View details →Negative / Null Result ReportOpen accessSocial Sciences
Will Grant, Brenda Moon, Janie Busby Grant · 2010 · Australian Journal of Political Science
The recent emergence of online social media has had a significant effect on the contemporary political landscape, yet our understanding of this remains less than complete. This article adds to current understanding of the online engagement…
View details →Negative / Null Result ReportPsychology
Gerald Thomas, Philippe Lucas, N. Rielle Capler et al. · 2013 · Current Drug Abuse Reviews
INTRODUCTION: This paper reports results from a preliminary observational study of ayahuasca-assisted treatment for problematic substance use and stress delivered in a rural First Nations community in British Columbia, Canada. METHODS: The…
View details →Negative / Null Result ReportOpen accessEarth and Planetary Sciences
Sarah S. T. Mak, Shyam Gopalakrishnan, Christian Carøe et al. · 2017 · GigaScience
Ancient DNA research has been revolutionized following development of next-generation sequencing platforms. Although a number of such platforms have been applied to ancient DNA samples, the Illumina series are the dominant choice today, mainly because of high production capacities and short read production. Recently a potentially attractive alternative platform for palaeogenomic data generation has been developed, the BGISEQ-500, whose sequence output are comparable with the Illumina series. In this study, we modified the standard BGISEQ-500 library preparation specifically for use on degraded
View details →Negative / Null Result ReportOpen accessNeuroscience
Donna M. Werling, Neelroop Parikshak, Daniel H. Geschwind · 2016 · Nature Communications
Autism spectrum disorder (ASD) is more prevalent in males, and the mechanisms behind this sex-differential risk are not fully understood. Two competing, but not mutually exclusive, hypotheses are that ASD risk genes are sex-differentially regulated, or alternatively, that they interact with characteristic sexually dimorphic pathways. Here we characterized sexually dimorphic gene expression in multiple data sets from neurotypical adult and prenatal human neocortical tissue, and evaluated ASD risk genes for evidence of sex-biased expression. We find no evidence for systematic sex-differential ex
View details →Negative / Null Result ReportOpen accessMaterials Science
Arjan J. Houtepen, Zeger Hens, Jonathan S. Owen et al. · 2016 · Chemistry of Materials
One of the greatest challenges in the field of semiconductor nanomaterials is to make trap-free nanocrystalline structures to attain a remarkable improvement of their optoelectronic performances. In semiconductor nanomaterials, a very high…
View details →Negative / Null Result ReportOpen accessMedicine
Rolf Jorde, Monica Sneve, Peter A. Torjesen et al. · 2010 · Nutrition Journal
BACKGROUND: In meta-analyses supplementation with vitamin D appears to reduce incidence of fractures, and in cross-sectional studies there is a positive association between serum 25-hydroxyvitamin D (25(OH)D) levels and bone mineral density (BMD). However, the effect of supplementation with high doses of vitamin D on BMD is more uncertain and could in theory have both positive and negative effects. METHODS: The study was a one year, double blind placebo-controlled intervention trial performed at the University Hospital of North Norway. 421 subjects, 21 - 70 years old, were included and 312 com
View details →Negative / Null Result ReportOpen accessSocial Sciences
Andrés Rodríguez‐Pose, Roberto Ezcurra · 2010 · Journal of Economic Geography
The global drive towards decentralization has been increasingly justified on the basis that greater transfers of resources to subnational governments are expected to deliver greater efficiency in the provision of public goods and services…
View details →Negative / Null Result ReportMedicine
Julie Agel, Todd Rockwood, David Klossner · 2016 · Clinical Journal of Sport Medicine
OBJECTIVE: To present data on the rate of anterior cruciate ligament (ACL) injury in 15 collegiate sports from 2004 to 2005 through 2012 to 2013 updating the 1988-1989 to 2003-2004 data. DESIGN: Prospectively designed descriptive…
View details →Replication FailureOpen accessMedicine
Gabrielle Kingsley, Anna Kowalczyk, Helen Taylor et al. · 2012 · Lara D. Veeken
OBJECTIVE: MTX is widely used to treat synovitis in PsA without supporting trial evidence. The aim of our study was to test the value of MTX in the first large randomized placebo-controlled trial (RCT) in PsA. METHODS: A 6-month…
View details →Negative / Null Result ReportOpen accessNeuroscience
Tom G. Hansen, Jacob Krabbe Pedersen, Steen W. Henneberg et al. · 2011 · Anesthesiology
BACKGROUND: Although animal studies have indicated that general anesthetics may result in widespread apoptotic neurodegeneration and neurocognitive impairment in the developing brain, results from human studies are scarce. We investigated…
View details →Negative / Null Result ReportOpen accessMedicine
Luis Paz‐Ares, Y Chen, Niels Reinmuth et al. · 2022 · ESMO Open
•Durvalumab plus EP showed sustained OS benefit over EP with a well-tolerated safety profile after median follow-up >3 years.•Three times more patients were estimated to be alive at 3 years when treated with durvalumab plus EP versus EP…
View details →Negative / Null Result ReportOpen accessEnvironmental Science
Linda Steg, Judith I. M. de Groot, Lieke Dreijerink et al. · 2011 · Society & Natural Resources
Results of two studies are reported, in which we compare the predictive power of three general behavioral antecedents (i.e., values, worldviews, and environmental concern) in explaining personal norms, behavioral intentions (i.e.,…
View details →Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Raymond Kan, Cesare Robotti, Jay Shanken · 2013 · The Journal of Finance
ABSTRACT Over the years, many asset pricing studies have employed the sample cross‐sectional regression (CSR) R 2 as a measure of model performance. We derive the asymptotic distribution of this statistic and develop associated model…
View details →Negative / Null Result ReportEconomics, Econometrics and Finance
Hakan Berument, Nildağ Başak Ceylan, Nükhet Doğan · 2010 · The Energy Journal
This paper examines how oil price shocks affect the output growth of selected MENA countries that are considered either net exporters or net importers of this commodity, but are too small to affect oil prices. That an individual country’s…
View details →Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Andrew J. Sharp, Elisavet Stathaki, Eugenia Migliavacca et al. · 2011 · Genome Research
X-chromosome inactivation (XCI) is a dosage compensation mechanism that silences the majority of genes on one X chromosome in each female cell. To characterize epigenetic changes that accompany this process, we measured DNA methylation…
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