Contribution of Coagulases towards Staphylococcus aureus Disease and Protective Immunity
Alice G. Cheng; Molly McAdow; Hwan Keun Kim; Taeok Bae; Dominique Missiakas; Olaf Schneewind · 2010 · PLoS Pathogens
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
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Abstract
The bacterial pathogen Staphylococcus aureus seeds abscesses in host tissues to replicate at the center of these lesions, protected from host immune cells via a pseudocapsule. Using histochemical staining, we identified prothrombin and fibrin within abscesses and pseudocapsules. S. aureus secretes two clotting factors, coagulase (Coa) and von Willebrand factor binding protein (vWbp). We report here that Coa and vWbp together are required for the formation of abscesses. Coa and vWbp promote the non-proteolytic activation of prothrombin and cleavage of fibrinogen, reactions that are inhibited wi
Abstract by Alice G. Cheng; Molly McAdow; Hwan Keun Kim; Taeok Bae; Dominique Missiakas; Olaf Schneewind, PLoS Pathogens (2010) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.1371/journal.ppat.1001036