Mast cells selectively produce inflammatory mediators and impact the early response to Chlamydia reproductive tract infection
Animamalar Mayavannan; Emily Shantz; Ian D. Haidl; Jun Wang; Jean S. Marshall · 2023 · Frontiers in Immunology
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
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Abstract
Introduction Chlamydia trachomatis ( C. trachomatis ) is a Gram-negative obligate intracellular bacterium that causes reproductive tract complications in women, including ectopic pregnancies and tubal factor infertility. We hypothesized that mast cells, which are common at mucosal barriers, may contribute to responses to Chlamydia infection and aimed to define human mast cell responses to C. trachomatis . Methods Human cord blood-derived mast cells (CBMCs) were exposed to C. trachomatis to assess bacterial uptake, mast cell degranulation, gene expression, and production of inflammatory mediato
Abstract by Animamalar Mayavannan; Emily Shantz; Ian D. Haidl; Jun Wang; Jean S. Marshall, Frontiers in Immunology (2023) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3389/fimmu.2023.1166068