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Browse the failure-mode index

21,239 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessSocial Sciences

Examining the replicability of backfire effects after standalone corrections

Toby Prike, Phoebe Blackley, Briony Swire‐Thompson et al. · 2023 · Cognitive Research Principles and Implications

Corrections are a frequently used and effective tool for countering misinformation. However, concerns have been raised that corrections may introduce false claims to new audiences when the misinformation is novel. This is because boosting the familiarity of a claim can increase belief in that claim, and thus exposing new audiences to novel misinformation-even as part of a correction-may inadvertently increase misinformation belief. Such an outcome could be conceptualized as a familiarity backfire effect, whereby a familiarity boost increases false-claim endorsement above a control-condition or

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Negative / Null Result ReportPsychology

Examining a motivational treatment and its impact on adolescents' reading comprehension and fluency

Christopher A. Wolters, Marcia A. Barnes, Paulina A. Kulesz et al. · 2016 · The Journal of Educational Research

The authors' purpose was to examine adolescents' reading motivation in relation to standardized assessments of reading comprehension and fluency. After a reading pretest, 60 ninth-grade students (M age = 14.9 years) were randomly assigned…

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Negative / Null Result ReportOpen accessArts and Humanities

Evaluation of the auricular surface method for subadult sex estimation on Italian modern (19th to 20th century) identified skeletal collections

Roberta Marino, Viola Tanganelli, Annalisa Pietrobelli et al. · 2020 · American Journal of Physical Anthropology

OBJECTIVES: Sex estimation in subadult skeletal remains is still considered highly problematic. The aim of this research is to test the reliability of the method of subadult sex assessment proposed by Luna and co-workers in 2017, based on…

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Negative / Null Result ReportNeuroscience

Dissociated Predegenerated Peripheral Nerve Transplants for Spinal Cord Injury Repair: A Comprehensive Assessment of Their Effects on Regeneration and Functional Recovery Compared to Schwann Cell Transplants

Caitlin E. Hill, Danika M. Brodak, Mary Bartlett Bunge · 2012 · Journal of Neurotrauma

Several recent studies suggest that predegenerated nerves (PDNs) or dissociated PDNs (dPDNs) can improve behavioral and histological outcomes following transplantation into the injured rat spinal cord. In the current study we tested the…

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Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology

ASSA: Fast identification of statistically significant interactions between long RNAs

Ivan Antonov, Andrey V. Marakhonov, Maria A. Zamkova et al. · 2018 · Journal of Bioinformatics and Computational Biology

The discovery of thousands of long noncoding RNAs (lncRNAs) in mammals raises a question about their functionality. It has been shown that some of them are involved in post-transcriptional regulation of other RNAs and form inter-molecular…

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Negative / Null Result ReportOpen accessMedicine

Neural growth hormone: regional regulation by estradiol and/or sex chromosome complement in male and female mice

Kayla M. Quinnies, Paul J. Bonthuis, Erin P. Harris et al. · 2015 · Biology of Sex Differences

BACKGROUND: Sex differences in pituitary growth hormone (GH) are well documented and coordinate maturation and growth. GH and its receptor are also produced in the brain where they may impact cognitive function and synaptic plasticity, and estradiol produces Gh sex differences in rat hippocampus. In mice, circulating estradiol increases Gh mRNA in female but not in male medial preoptic area (mPOA); therefore, additional factors regulate sexually dimorphic Gh expression in the brain. Thus, we hypothesized that sex chromosomes interact with estradiol to promote sex differences in GH. Here, we as

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Negative / Null Result ReportMedicine

Studies on protein content, protease activity, antioxidants potential, melanin composition, glucosinolate and pectin constitution with brief statisticalanalysis in some medicinally significant fruit peels

Saranya Chitturi, Venkata Gopich, Talatam et al. · 2013 · Der pharmacia lettre

Recently, many studies have been oriented towards improving methods and efficiency of recovery from different fruit industry wastes. The investigations carried out were mainly aimed at evaluating Pectin content, Protease activity, Protein…

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Negative / Null Result ReportOpen accessNursing

Docosahexaenoic acid for reading, working memory and behavior in UK children aged 7-9: A randomized controlled trial for replication (the DOLAB II study)

Paul Montgomery, Thees F. Spreckelsen, Alice Burton et al. · 2018 · PLoS ONE

BACKGROUND: Omega-3 fatty acids are central to brain-development of children. Evidence from clinical trials and systematic reviews demonstrates the potential of long-chain Omega-3 supplementation for learning and behavior. However, findings are inconclusive and in need of robust replication studies since such work is lacking. OBJECTIVES: Replication of the 2012 DOLAB 1 study findings that a dietary supplementation with the long-chain omega-3 docosahexaenoic acid (DHA) had beneficial effects on the reading, working memory, and behavior of healthy schoolchildren. DESIGN: Parallel group, fixed-do

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Negative / Null Result ReportOpen accessMedicine

Genome‐wide time‐to‐event analysis on smoking progression stages in a family‐based study

Liang He, Janne Pitkäniemi, Kauko Heikkilä et al. · 2016 · Brain and Behavior

BACKGROUND: Various pivotal stages in smoking behavior can be identified, including initiation, conversion from experimenting to established use, development of tolerance, and cessation. Previous studies have shown high heritability for age of smoking initiation and cessation; however, time-to-event genome-wide association studies aiming to identify underpinning genes that accelerate or delay these transitions are missing to date. METHODS: We investigated which single nucleotide polymorphisms (SNPs) across the whole genome contribute to the hazard ratio of transition between different stages o

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Negative / Null Result ReportOpen accessMedicine

Association of common candidate variants with vascular malformations and intracranial hemorrhage in hereditary hemorrhagic telangiectasia

Ludmila Pawlikowska, Jeffrey Nelson, Diana E. Guo et al. · 2018 · Molecular Genetics & Genomic Medicine

BACKGROUND: Hereditary hemorrhagic telangiectasia (HHT) is caused by mutations in TGFβ/BMP9 pathway genes and characterized by vascular malformations (VM) including arteriovenous malformations (AVM) in lung, liver, and brain, which lead to severe complications including intracranial hemorrhage (ICH) from brain VM. The clinical heterogeneity of HHT suggests a role for genetic modifier effects. Common variants in loci that modify phenotype severity in Tgfb knockout mice were previously reported as associated with lung AVM in HHT. Common variants in candidate genes were reported as associated wit

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Negative / Null Result ReportNeuroscience

Determiner selection in romance languages: Evidence from French.

Alice Foucart, Holly P. Branigan, Ellen Gurman Bard · 2010 · Journal of Experimental Psychology Learning Memory and Cognition

Determiner selection requires the retrieval of the noun's syntactic features (e.g., gender) and sometimes of its phonological features. Miozzo and Caramazza (1999) argued that the selection of determiners in Germanic languages is more…

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Diabetes and Pancreatic Cancer

Burney, Saira, Muhammad Wasif Saif, Saif, Muhammad Wasif et al. · 2013 · PubMed

CONTEXT: Pancreatic cancer is the fourth leading cause of cancer mortality in the United States. Most of the patients are diagnosed in the metastatic staging. Consolidated risk factors include chronic pancreatitis, smoking and family…

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Genome-wide association study of treatment-related toxicity two years following radiotherapy for breast cancer

Harkeran K. Jandu, Colin Veal, Laura Fachal et al. · 2023 · Radiotherapy and Oncology

Background and purpose Up to a quarter of breast cancer patients treated by surgery and radiotherapy experience clinically significant toxicity. If patients at high risk of adverse effects could be identified at diagnosis, their treatment could be tailored accordingly. This study was designed to identify common single nucleotide polymorphisms (SNPs) associated with toxicity two years following whole breast radiotherapy. Materials and Methods A genome-wide association study (GWAS) was performed in 1,640 breast cancer patients with complete SNP, clinical, treatment and toxicity data, recruited a

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Negative / Null Result ReportOpen accessMedicine

Comparison of the Physical Demands of Friendly Matches and Different Types On-Field Integrated Training Sessions in Professional Soccer Players

Jesús Giménez, Julen Castellano, Patrycja Lipińska et al. · 2020 · International Journal of Environmental Research and Public Health

The aim of this study was to investigate the relationships among physical demands of two friendly matches (FMs) and three task training sessions (TS1,2,3) combining in a different way: a Small-Sided Game (SSG), Mini-Goals (MG), a ball Circuit Training (CT) and a Large-Sided Game (LSG): SSG+MG+LSG (TS1), SSG+CT+LSG (TS2) and MG+CT+LSG (TS3). The TS and match demands in running intensities were monitored in fourteen professional soccer players (age = 23.2 ± 2.7 years, height = 178 ± 6 cm, body mass = 73.2 ± 6.9 kg, mean and SD, respectively) using 10-Hz global positioning system devices, and pla

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Negative / Null Result Report

Assessment of Statistically Significant Command-Following in Pediatric Patients with Disorders of Consciousness, Based on Visual, Auditory and Tactile Event-Related Potentials

Marian Dovgialo, Anna Chabuda, Anna Duszyk et al. · 2019 · International Journal of Neural Systems

Disorders of consciousness (DOC) are among the major challenges of contemporary medicine, mostly due to the high rates of misdiagnoses in clinical assessment, based on behavioral scales. This turns our attention to potentially objective…

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Negative / Null Result ReportOpen accessMedicine

Impact of the Glucagon Assay When Assessing the Effect of Chronic Liraglutide Therapy on Glucagon Secretion

Caroline K. Kramer, Bernard Zinman, Haysook Choi et al. · 2017 · The Journal of Clinical Endocrinology & Metabolism

Context: Glucagon-like peptide-1 agonists acutely lower serum glucagon. However, in the Liraglutide and β-Cell Repair (LIBRA) Trial, 48-week treatment with liraglutide yielded lower/unchanged fasting glucagon but, surprisingly, enhanced…

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Negative / Null Result Report

No statistically significant kinematic difference found between a cruciate-retaining and posterior-stabilised Triathlon knee arthroplasty

N. C. Hunt, K. M. Ghosh, A. P. Blain et al. · 2015 · The Bone & Joint Journal

The aim of this study was to compare the maximum laxity conferred by the cruciate-retaining (CR) and posterior-stabilised (PS) Triathlon single-radius total knee arthroplasty (TKA) for anterior drawer, varus–valgus opening and rotation in…

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Pharmacoepigenetics of hypertension: genome-wide methylation analysis of responsiveness to four classes of antihypertensive drugs using a double-blind crossover study design

Marja-Liisa Nuotio, Heini Sánez Tähtisalo, Alexandra Lahtinen et al. · 2022 · Epigenetics

Essential hypertension remains the leading risk factor of global disease burden, but its treatment goals are often not met. We investigated whether DNA methylation is associated with antihypertensive responses to a diuretic, a beta-blocker, a calcium channel blocker or an angiotensin receptor antagonist. In addition, since we previously showed an SNP at the transcription start site (TSS) of the catecholamine biosynthesis-related ACY3 gene to associate with blood pressure (BP) response to beta-blockers, we specifically analysed the association of methylation sites close to the ACY3 TSS with BP

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

VEGF receptors mediate hypoxic remodeling of adult ovine carotid arteries

Olayemi O. Adeoye, Vincent Bouthors, Margaret C. Hubbell et al. · 2014 · Journal of Applied Physiology

Recent studies suggest that VEGF contributes to hypoxic remodeling of arterial smooth muscle, although hypoxia produces only transient increases in VEGF that return to normoxic levels despite sustained changes in arterial structure and…

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Negative / Null Result ReportOpen accessNeuroscience

Amygdala and nucleus accumbens involvement in appetitive extinction

Onno Kruse, S. Klein, Isabell Tapia León et al. · 2020 · Human Brain Mapping

Extinction of appetitive conditioning is regarded as an important model for the treatment of psychiatric disorders like addiction. However, very few studies have investigated its neural correlates. Therefore, we investigated neural…

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Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology

Replication of plasmids derived from Shiga toxin-converting bacteriophages in starved Escherichia coli

Bożena Nejman-Faleńczyk, Beata Nadratowska-Wesołowska, Agnieszka Szalewska-Pałasz et al. · 2010 · Microbiology

The pathogenicity of Shiga toxin-producing Escherichia coli (STEC) depends on the expression of stx genes that are located on lambdoid prophages. Effective toxin production occurs only after prophage induction, and one may presume that…

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Negative / Null Result ReportOpen accessSocial Sciences

Does governance matter to ensure significant effect of foreign direct investment on poverty reduction? Evidence from developing and emerging countries

Zouhaier Aloui, Mekki Hamdaoui, Samir Maktouf · 2024 · Transnational Corporation Review

This paper examines the moderating role of governance in the effect of Foreign Direct Investment (FDI) on poverty using simultaneous equations models for sub-Saharan African, Asian, Latin American and Eastern European countries over the…

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Negative / Null Result Report

Case studies to demonstrate challenges of driven piles on rock

Kam Ng, Todd Sullivan · 2017 · Geotechnical Research

In Wyoming, pile foundations for bridges are often driven on rock materials because of the state’s shallow bedrock stratigraphy. Unfortunately, no static analysis methods are currently available for estimating the resistance of these…

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Negative / Null Result ReportSocial Sciences

Psychometric Properties of the Institutional Betrayal Questionnaire, Version 2: Evidence for a Two-Factor Model

Anthony N. Reffi, Caitlin M. Pinciotti, Holly K. Orcutt · 2018 · Journal of Interpersonal Violence

Institutional betrayal reflects the failings of a trusted institution to prevent or respond appropriately to negative experiences. Following sexual assault, survivors who encounter institutional betrayal may experience greater distress and…

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