21,691 real negative results, null findings, and replication failures. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Aidan E. Gilchrist, Brendan A. C. Harley · 2022 · Advanced Healthcare Materials
Abstract Hematopoietic stem cells are the progenitors of the blood and immune system and represent the most widely used regenerative therapy. However, their rarity and limited donor base necessitate the design of ex vivo systems that…
View details →Peter D. Dunning · 2020 · Structural and Multidisciplinary Optimization
Abstract This paper investigates the application of the co-rotational method to solve geometrically nonlinear topology optimization problems. The main benefit of this approach is that the tangent stiffness matrix is naturally positive definite, which avoids some numerical issues encountered when using other approaches. Three different methods for constructing the tangent stiffness matrix are investigated: a simplified method, where the linear elastic stiffness matrix is simply rotated; the consistent method, where the tangent stiffness is derived by differentiating residual forces by displacem
View details →Xiangxu Zou, Hui Zhang, Jie Zuo et al. · 2016 · Scientific Reports
Abstract To identify the facilitation effect of a cool-season aquatic macrophyte (FE am ) for use in effluent purification via constructed floating wetlands (CFWs) and to determine the possible pathways used during a winter period with an…
View details →Christopher W. Belter, Neal K. Kaske · 2016 · College & Research Libraries
Although cited reference studies are common in the library and information science literature, they are rarely performed in nonacademic institutions or in the atmospheric and oceanic sciences. In this paper, we analyze more than 400,000…
View details →Aimée C. Colbath, Steven W. Dow, Leone S. Hopkins et al. · 2020 · Equine Veterinary Journal
Abstract Background Allogeneic and autologous bone marrow‐derived mesenchymal stem cells (BMDMSCs) have been administered in equine joints for their anti‐inflammatory effects. However, allogeneic BMDMSC offer multiple clinical and…
View details →Rachel Charlton, Christine Damase‐Michel, Caroline Hurault‐Delarue et al. · 2019 · Pharmacoepidemiology and Drug Safety
Abstract Objectives In November 2014, the CMDh (a regulatory body representing EU Member States) advised doctors not to prescribe sodium valproate for epilepsy or bipolar disorder in preg nant women, in women who can become pregnant, or in…
View details →Kittisak Sanon, Takashi Hatayama, Antonín Tichý et al. · 2022 · Dental Materials Journal
This study investigated the influence of application/wash-out times of sodium hypochlorite (NaOCl) and hypochlorous acid (HOCl) on dentin bond strength of one-step self-etch adhesives (1-SEAs). Human coronal dentin discs with a…
View details →Da‐Tian Bau · 2011 · The Chinese Journal of Physiology
Many articles have reported the caveolin-1 gene to be down-regulated thus suggesting that it might be a candidate tumor suppressor gene in many tumors. However, its involvement in bladder cancer is not clear and may be depending on…
View details →Tracy Leskey, Heather Andrews, Angelika Bády et al. · 2021 · Journal of Economic Entomology
Brown marmorated stink bug, Halyomorpha halys, is native to Asia and has invaded North America and Europe inflicting serious agricultural damage to specialty and row crops. Tools to monitor the spread of H. halys include traps baited with…
View details →Andrea J. Savio, Mathieu Lemire, Miralem Mrkonjic et al. · 2012 · PLoS ONE
Single nucleotide polymorphisms (SNPs) are the most common form of genetic variation. We previously demonstrated that SNPs (rs1800734, rs749072, and rs13098279) in the MLH1 gene region are associated with MLH1 promoter island methylation, loss of MLH1 protein expression, and microsatellite instability (MSI) in colorectal cancer (CRC) patients. Recent studies have identified less CpG-dense "shore" regions flanking many CpG islands. These shores often exhibit distinct methylation profiles between different tissues and matched normal versus tumor cells of patients. To date, most epigenetic studie
View details →RuoLi Chen, Mohammad Alkataan Ahmed, Nicholas Robert Forsyth · 2022 · Biomolecules
Cells respond to reduced oxygen availability predominately by activation of the hypoxia-inducible factor (HIF) pathway. HIF activation upregulates hundreds of genes that help cells survive in the reduced oxygen environment. The aim of this…
View details →David R. Chalcraft · 2019 · Ecology Letters
Abstract Recent simulations suggest that ecologists can enhance the predictive ability of models by designing experiments that maximise the number of levels of an experimental factor by sacrificing replication. Here, I describe how these…
View details →Wanying Liang, Lihong Wang, Jian‐Hang Wei et al. · 2021 · Scientific Reports
Klotho, an important anti-aging protein, may be related to elevated blood pressure (BP) and arterial stiffness. We aimed to investigate associations between the serum klotho concentration and peripheral/central BP and arterial stiffness based on the carotid-femoral pulse wave velocity (cfPWV) in a Chinese population. We invited all inhabitants aged ≥ 18 years in two Dali communities for participation. The SphygmoCor system was used to record radial arterial waveforms. Aortic waveforms were derived using a generalized transfer function. The central BP was assessed by calibrating the brachial BP
View details →Haijiang Zhou · 2020 · World Journal of Emergency Medicine
BACKGROUND: To evaluate the accuracy of National Early Warning Score (NEWS) in predicting clinical outcomes (28-day mortality, intensive care unit [ICU] admission, and mechanical ventilation use) for septic patients with community-acquired…
View details →Zhili Wang, Mingsheng Liu, Zhengyi Cai et al. · 2020 · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Objective To determine the practical diagnostic utility of split-hand index (SI) values calculated from F-wave persistence (SIFP) and the F/M amplitude ratio (SIF/M) for differentiating patients with amyotrophic lateral sclerosis (ALS)…
View details →Daniel Rasbash, Kevin Joseph Dillman, Jukka Heinonen et al. · 2023 · Sustainability
Electrification is considered key to decarbonizing the transport sector. While electric vehicles (EVs) lack tailpipe emissions, battery and electricity production can lead to significant emissions. This study analysed whether EVs can effectively mitigate GHG emissions in North America, by calculating two GHG breakeven indicators for EVs and comparing them to internal combustion engine vehicles (ICEVs). EV life cycle emissions were compared to those of ICEVs in Canada, Mexico, and the USA. In addition, this study considered potential national electricity grids evolutions and improvements in bat
View details →Yun Gi Kim, Jong‐Il Choi, Ki Yung Boo et al. · 2019 · Clinical Cardiology
Abstract Background Age is a well‐established risk factor for thromboembolic events in patients with atrial fibrillation (AF). However, the mechanism underlying the association between age and thromboembolic events in AF remains unknown. Methods The prognostic value of age as a risk factor for thromboembolic events was analyzed using data from the Korean National Health Insurance Service (NHIS). In a large‐scale single‐center registry, cardiac hemodynamic parameters were examined to elucidate the cause of increased risk of thromboembolic events in older patients. Results NHIS sample cohort dat
View details →Katja Bächli, Patrick R. Schmidlin, Florian J. Wegehaupt et al. · 2019 · Materials
To assess the remineralizing potential of dentin matrix proteins and enamel matrix derivatives (DMPs and EMDs) after application on artificially induced dentin lesions, given the hypothesis that these materials increase the mineral uptake, binding, and mineralization. Forty-eight caries-free human premolars were used. Teeth were cut, polished, and embedded, leaving an open window on the root surface, of which one-third was covered with a flowable composite to preserve the healthy untreated dentin. Then, samples were demineralized in Buskes solution for 33 days. A micro-CT scan prior to treatme
View details →Melissa B. Gilkey, Brigid K. Grabert, Jennifer Heisler-MacKinnon et al. · 2022 · PEDIATRICS
BACKGROUND AND OBJECTIVES: US health departments routinely conduct in-person quality improvement (QI) coaching to strengthen primary care clinics' vaccine delivery systems, but this intervention achieves only small, inconsistent…
View details →Marlee R. Labroo, Jeffrey B. Endelman, Dorcus C. Gemenet et al. · 2023 · Theoretical and Applied Genetics
KEY MESSAGE: Reciprocal recurrent selection sometimes increases genetic gain per unit cost in clonal diploids with heterosis due to dominance, but it typically does not benefit autopolyploids. Breeding can change the dominance as well as additive genetic value of populations, thus utilizing heterosis. A common hybrid breeding strategy is reciprocal recurrent selection (RRS), in which parents of hybrids are typically recycled within pools based on general combining ability. However, the relative performances of RRS and other breeding strategies have not been thoroughly compared. RRS can have re
View details →Maureen van Eijnatten, Leonardo Rundo, Batenburg, Joost et al. · 2021 · Data Archiving and Networked Services (DANS)
Background and Objectives: Deep learning is being increasingly used for deformable image registration and unsupervised approaches, in particular, have shown great potential. However, the registration of abdominopelvic Computed Tomography…
View details →Qiang Liu, Kevin K. Lin, Bogi Andersen et al. · 2010 · Bioinformatics
Abstract Motivation: Time-course gene expression datasets provide important insights into dynamic aspects of biological processes, such as circadian rhythms, cell cycle and organ development. In a typical microarray time-course experiment,…
View details →Daniel M. Goldenholz, Celena Eccleston, Robert Moss et al. · 2024 · Epilepsia
OBJECTIVE: Recently, a deep learning artificial intelligence (AI) model forecasted seizure risk using retrospective seizure diaries with higher accuracy than random forecasts. The present study sought to prospectively evaluate the same…
View details →Orekoya Adedapo, Norbert Boros, Anna Boglárka Dálnoki et al. · 2024 · Discover Sustainability
Abstract The research examined the ability of each treatment to recover a known quantity of particles and the impact on identifying polymer type using a microscope. By conducting extensive research on the changes induced in the chemical…
View details →Anca Jivănescu, Adrian Bara, Andrei-Bogdan Faur et al. · 2021 · Applied Sciences
Is the accuracy of the older generation of IOSs an impediment for obtaining a quality intraoral digital impression? The aim of this study was to evaluate the differences in accuracy between four intraoral scanners (two of the latest IOSs…
View details →Eyüp Özkan, Aslan Erdoğan, Ali Karagöz et al. · 2023 · Angiology
This study compared the predictive power of the systemic immune-inflammation index (SII) and Naples prognostic score (NPS) in determining the severity of coronary artery disease (CAD). The study included 1138 patients who underwent…
View details →Jekaterina Kazantseva, Roman Ivanov, Michael Gasik et al. · 2016 · Scientific Reports
Abstract Three-dimensional (3D) customized scaffolds capable to mimic a native extracellular matrix open new frontiers in cells manipulation and advanced therapy. The major challenge is in a proper substrate for in vitro models on…
View details →Endre Willassen, Jon-Ivar Westgaard, Jon Anders Kongsrud et al. · 2022 · PeerJ
To protect and restore ecosystems and biodiversity is one of the 10 challenges identified by the United Nations’s Decade of the Ocean Science. In this study we used eDNA from sediments collected in two fjords of the Svalbard archipelago…
View details →Bente Silnes Tandberg, Kathrine Frey Frøslie, Trond Markestad et al. · 2019 · Acta Paediatrica
Abstract Aim The aim was to compare growth in very premature infants cared for in a single‐family room (SFR) and an open‐bay (OB) unit. We recorded duration of parental presence and skin‐to‐skin contact as proxies for parental involvement…
View details →Carolina Diller, Miguel Castañeda-Zárate, Steven D. Johnson · 2019 · Biology Letters
Bird pollination systems are dominated by specialist nectarivores, such as hummingbirds in the Americas and sunbirds in Africa. Opportunistic (generalist) avian nectarivores such as orioles, weavers and bulbuls have also been implicated as…
View details →