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Browse the failure-mode index

21,239 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result Report

Skin‐to‐skin contact during eye examination did not reduce pain compared to standard care with parental support in preterm infants

Laila Kristoffersen, Ragnhild Støen, Håkon Bergseng et al. · 2019 · Acta Paediatrica

Abstract Aim We compared the pain relieving effect of skin‐to‐skin contact versus standard care in the incubator during screening for retinopathy of prematurity. Methods This randomised crossover study included 35 preterm infants of less…

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Negative / Null Result ReportOpen accessMedicine

Effect of high-volume hemofiltration on children with sepsis

Botao Ning, Sheng Ye, Yi Lyu et al. · 2020 · Translational Pediatrics

BACKGROUND: Sepsis has always been a challenge in pediatric intensive care unit (PICU) with poor prognosis. In order to evaluate the effect between routine continuous renal replacement therapy (CRRT) and high-volume hemofiltration (HVHF)…

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Negative / Null Result ReportOpen accessMedicine

Outcome is unchanged by adding vincristine upfront to the Malawi 28‐day protocol for endemic Burkitt lymphoma

Sarita Depani, Kondwani Joseph Banda, Simon Bailey et al. · 2015 · Pediatric Blood & Cancer

BACKGROUND: We previously reported a 28-day treatment protocol for children with endemic Burkitt lymphoma (BL) which included four doses of cyclophosphamide (CPM), intrathecal methotrexate and hydrocortisone (IT MTX/HC) at Queen Elizabeth…

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Negative / Null Result ReportOpen accessMedicine

Effects of Changes in the Levels of Damage-Associated Molecular Patterns Following Continuous Veno–Venous Hemofiltration Therapy on Outcomes in Acute Kidney Injury Patients With Sepsis

Jie Wu, Jianan Ren, Qinjie Liu et al. · 2019 · Frontiers in Immunology

Background: Continuous veno–venous hemofiltration (CVVH) could influence immunomodulation by cytokine removal. Damage-associated molecular patterns (DAMPs) are released by injured cells and have roles in sepsis. We investigated if the magnitude of DAMPs removal was associated with mortality in patients with sepsis undergoing CVVH. Methods: We conducted a prospective, observational study on patients acquiring CVVH at department of surgery, Jinling Hospital. Circulating levels of DAMPs (mitochondrial DNA [mtDNA]; nuclear DNA [nDNA]; heat shock protein [HSP]70) and cytokines were measured at the

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Negative / Null Result Report

Can we find the right balance in cause‐related marketing? Analyzing the boundaries of balance theory in evaluating brand‐cause partnerships

Joseph T. Yun, Brittany R. L. Duff, Patrick Vargas et al. · 2019 · Psychology & Marketing

Abstract Cause‐related marketing (CRM) refers to the phenomenon where brands partner with causes, such as nonprofit organizations. Consumers may see some CRM partnerships as less compatible than others, however the level of perceived…

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Negative / Null Result ReportOpen accessMedicine

The effects of midazolam or propofol plus fentanyl on ICU mortality: a retrospective study based on the MIMIC-IV database

Wen Sun, Yan Yang, Shidong Hu et al. · 2022 · Annals of Translational Medicine

Background: Patients in the intensive care unit (ICU) are often under stress and fail to cooperate well with invasive treatments. Analgesia and sedation are of great significance for reducing the suffering of patients and ensuring the…

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Negative / Null Result ReportOpen accessMedicine

Nebulized heparin and salbutamol versus salbutamol alone in acute exacerbations of chronic obstructive pulmonary disease requiring mechanical ventilation: a double-blind randomized controlled trial

Tarek Mohamed Ashoor, Ahmad Mahmoud Hasseb, Ibrahim M. Esmat · 2020 · Korean journal of anesthesiology

Background: Nebulized heparin has been effectively used in the management of many pulmonary diseases. However, its effect on mechanically ventilated patients with acute exacerbation chronic obstructive pulmonary disease (AECOPD) has never…

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Negative / Null Result ReportOpen accessMedicine

A comparison of different vitrification devices and the effect of blastocoele collapse on the cryosurvival of <i>in vitro</i> produced porcine embryos

Louise Katherine Bartolac, Jenna Lowe, George Koustas et al. · 2015 · Journal of Reproduction and Development

The aim of this study was to determine the optimum conditions for vitrifying in vitro produced day 7 porcine embryos using different vitrification devices and blastocoele collapse methods. Firstly embryos were collapsed by micro-pipetting,…

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Negative / Null Result ReportOpen accessPsychology

How to tell a happy person: Accuracy of subjective well-being perception from texts

Olga Stavrova, Lena Haarmann · 2019 · Motivation and Emotion

Abstract Although perceptions of subjective well-being (SWB) in unacquainted others have been shown to play a major role in impression formation, little is known about how accurate such perceptions are. In two original studies and one pre-registered replication, we explored the accuracy of life satisfaction and happiness judgments from texts and its underlying mechanisms (use of linguistic cues). Participants filled in life satisfaction and happiness measures and completed a brief writing task. Another sample of participants judged the targets’ life satisfaction and happiness from the obtained

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Analysis of Genome-Wide Association Study (GWAS) data looking for replicating signals in Alzheimer's disease (AD).

Hui Shi, Christopher Medway, James M. Bullock et al. · 2010 · PubMed

We have performed cross-platform comparisons of output from 4 GWAS in late-onset Alzheimer's disease (LOAD) - Reiman et al., 2007; Li et al., 2008; Beecham et al., 2008 and Carrasquillo et al., 2009 to search for new association signals.…

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Negative / Null Result ReportOpen accessPsychology

Some Alternatives? Event-Related Potential Investigation of Literal and Pragmatic Interpretations of Some Presented in Isolation

Cécile Barbet, Guillaume Thierry · 2016 · Frontiers in Psychology

In sentence verification tasks involving under-informative statements such as Some elephants are mammals, some adults appear more tolerant to pragmatic violations than others. The underlying causes of such inter-individual variability remain however essentially unknown. Here, we investigated inter-individual variation in adults deriving the scalar inference "not all" triggered by the quantifier some. We first assessed the individual intolerance to pragmatic violations in adult participants presented with under-informative some-statements (e.g., Some infants are young). We then recorded event-r

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Negative / Null Result ReportOpen accessMedicine

Overactive bladder and sleep disturbance have a significant effect on indoor falls: Results from the community health survey in Japan

Sakae Konishi, Shingo Hatakeyama, Atsushi Imai et al. · 2020 · LUTS Lower Urinary Tract Symptoms

OBJECTIVES: To evaluate the effect of overactive bladder (OAB) and frailty on indoor fall events in community-dwelling adults aged 50 or older. METHODS: We conducted a cross-sectional study involving 723 adults between 2016 and 2017 in…

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Negative / Null Result ReportPsychology

Early Childhood Teachers’ Perception of Creative Personality as a Predictor of Their Support of pedagogy important for fostering Creativity: A Chinese Perspective

Rebecca Hun Ping Cheung, Magdalena Mo Ching Mok · 2018 · Creativity Research Journal

Previous studies have suggested that teacher’s personality traits and pedagogy are the important areas of investigation in creativity research; however, little is known about the relationship between teachers’ personality traits and…

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Heritability and Genome-Wide Association Analyses of Human Gait Suggest Contribution of Common Variants

Hieab H.H. Adams, Vincentius J.A. Verlinden, Michele L. Callisaya et al. · 2015 · The Journals of Gerontology Series A

Human gait is a complex neurological and musculoskeletal function, of which the genetic basis remains largely unknown. To determine the influence of common genetic variants on gait parameters, we studied 2,946 participants of the Rotterdam…

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Negative / Null Result ReportOpen accessSocial Sciences

Examining the replicability of backfire effects after standalone corrections

Toby Prike, Phoebe Blackley, Briony Swire‐Thompson et al. · 2023 · Cognitive Research Principles and Implications

Corrections are a frequently used and effective tool for countering misinformation. However, concerns have been raised that corrections may introduce false claims to new audiences when the misinformation is novel. This is because boosting the familiarity of a claim can increase belief in that claim, and thus exposing new audiences to novel misinformation-even as part of a correction-may inadvertently increase misinformation belief. Such an outcome could be conceptualized as a familiarity backfire effect, whereby a familiarity boost increases false-claim endorsement above a control-condition or

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Negative / Null Result ReportPsychology

Examining a motivational treatment and its impact on adolescents' reading comprehension and fluency

Christopher A. Wolters, Marcia A. Barnes, Paulina A. Kulesz et al. · 2016 · The Journal of Educational Research

The authors' purpose was to examine adolescents' reading motivation in relation to standardized assessments of reading comprehension and fluency. After a reading pretest, 60 ninth-grade students (M age = 14.9 years) were randomly assigned…

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Negative / Null Result ReportOpen accessArts and Humanities

Evaluation of the auricular surface method for subadult sex estimation on Italian modern (19th to 20th century) identified skeletal collections

Roberta Marino, Viola Tanganelli, Annalisa Pietrobelli et al. · 2020 · American Journal of Physical Anthropology

OBJECTIVES: Sex estimation in subadult skeletal remains is still considered highly problematic. The aim of this research is to test the reliability of the method of subadult sex assessment proposed by Luna and co-workers in 2017, based on…

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Negative / Null Result ReportNeuroscience

Dissociated Predegenerated Peripheral Nerve Transplants for Spinal Cord Injury Repair: A Comprehensive Assessment of Their Effects on Regeneration and Functional Recovery Compared to Schwann Cell Transplants

Caitlin E. Hill, Danika M. Brodak, Mary Bartlett Bunge · 2012 · Journal of Neurotrauma

Several recent studies suggest that predegenerated nerves (PDNs) or dissociated PDNs (dPDNs) can improve behavioral and histological outcomes following transplantation into the injured rat spinal cord. In the current study we tested the…

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Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology

ASSA: Fast identification of statistically significant interactions between long RNAs

Ivan Antonov, Andrey V. Marakhonov, Maria A. Zamkova et al. · 2018 · Journal of Bioinformatics and Computational Biology

The discovery of thousands of long noncoding RNAs (lncRNAs) in mammals raises a question about their functionality. It has been shown that some of them are involved in post-transcriptional regulation of other RNAs and form inter-molecular…

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Negative / Null Result ReportOpen accessMedicine

Neural growth hormone: regional regulation by estradiol and/or sex chromosome complement in male and female mice

Kayla M. Quinnies, Paul J. Bonthuis, Erin P. Harris et al. · 2015 · Biology of Sex Differences

BACKGROUND: Sex differences in pituitary growth hormone (GH) are well documented and coordinate maturation and growth. GH and its receptor are also produced in the brain where they may impact cognitive function and synaptic plasticity, and estradiol produces Gh sex differences in rat hippocampus. In mice, circulating estradiol increases Gh mRNA in female but not in male medial preoptic area (mPOA); therefore, additional factors regulate sexually dimorphic Gh expression in the brain. Thus, we hypothesized that sex chromosomes interact with estradiol to promote sex differences in GH. Here, we as

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Negative / Null Result ReportMedicine

Studies on protein content, protease activity, antioxidants potential, melanin composition, glucosinolate and pectin constitution with brief statisticalanalysis in some medicinally significant fruit peels

Saranya Chitturi, Venkata Gopich, Talatam et al. · 2013 · Der pharmacia lettre

Recently, many studies have been oriented towards improving methods and efficiency of recovery from different fruit industry wastes. The investigations carried out were mainly aimed at evaluating Pectin content, Protease activity, Protein…

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Negative / Null Result ReportOpen accessNursing

Docosahexaenoic acid for reading, working memory and behavior in UK children aged 7-9: A randomized controlled trial for replication (the DOLAB II study)

Paul Montgomery, Thees F. Spreckelsen, Alice Burton et al. · 2018 · PLoS ONE

BACKGROUND: Omega-3 fatty acids are central to brain-development of children. Evidence from clinical trials and systematic reviews demonstrates the potential of long-chain Omega-3 supplementation for learning and behavior. However, findings are inconclusive and in need of robust replication studies since such work is lacking. OBJECTIVES: Replication of the 2012 DOLAB 1 study findings that a dietary supplementation with the long-chain omega-3 docosahexaenoic acid (DHA) had beneficial effects on the reading, working memory, and behavior of healthy schoolchildren. DESIGN: Parallel group, fixed-do

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Negative / Null Result ReportOpen accessMedicine

Genome‐wide time‐to‐event analysis on smoking progression stages in a family‐based study

Liang He, Janne Pitkäniemi, Kauko Heikkilä et al. · 2016 · Brain and Behavior

BACKGROUND: Various pivotal stages in smoking behavior can be identified, including initiation, conversion from experimenting to established use, development of tolerance, and cessation. Previous studies have shown high heritability for age of smoking initiation and cessation; however, time-to-event genome-wide association studies aiming to identify underpinning genes that accelerate or delay these transitions are missing to date. METHODS: We investigated which single nucleotide polymorphisms (SNPs) across the whole genome contribute to the hazard ratio of transition between different stages o

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Negative / Null Result ReportOpen accessMedicine

Association of common candidate variants with vascular malformations and intracranial hemorrhage in hereditary hemorrhagic telangiectasia

Ludmila Pawlikowska, Jeffrey Nelson, Diana E. Guo et al. · 2018 · Molecular Genetics & Genomic Medicine

BACKGROUND: Hereditary hemorrhagic telangiectasia (HHT) is caused by mutations in TGFβ/BMP9 pathway genes and characterized by vascular malformations (VM) including arteriovenous malformations (AVM) in lung, liver, and brain, which lead to severe complications including intracranial hemorrhage (ICH) from brain VM. The clinical heterogeneity of HHT suggests a role for genetic modifier effects. Common variants in loci that modify phenotype severity in Tgfb knockout mice were previously reported as associated with lung AVM in HHT. Common variants in candidate genes were reported as associated wit

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Negative / Null Result ReportNeuroscience

Determiner selection in romance languages: Evidence from French.

Alice Foucart, Holly P. Branigan, Ellen Gurman Bard · 2010 · Journal of Experimental Psychology Learning Memory and Cognition

Determiner selection requires the retrieval of the noun's syntactic features (e.g., gender) and sometimes of its phonological features. Miozzo and Caramazza (1999) argued that the selection of determiners in Germanic languages is more…

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