Significant Differences in RNA Structure Destabilization by HIV-1 Gag∆p6 and NCp7 Proteins
Micah J. McCauley; Ioulia Rouzina; Jasmine Li; Megan E. Núñez; Mark C. Williams · 2020 · Viruses
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
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Abstract
Retroviral nucleocapsid (NC) proteins are nucleic acid chaperones that play distinct roles in the viral life cycle. During reverse transcription, HIV-1 NC facilitates the rearrangement of nucleic acid secondary structures, allowing the transactivation response (TAR) RNA hairpin to be transiently destabilized and annealed to a complementary RNA hairpin. In contrast, during viral assembly, NC, as a domain of the group-specific antigen (Gag) polyprotein, binds the genomic RNA and facilitates packaging into new virions. It is not clear how the same protein, alone or as part of Gag, performs such d
Abstract by Micah J. McCauley; Ioulia Rouzina; Jasmine Li; Megan E. Núñez; Mark C. Williams, Viruses (2020) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3390/v12050484