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Browse the failure-mode index

21,165 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessDentistry

Accuracy of four intraoral scanners in oral implantology: a comparative in vitro study

Mario Imburgia, Silvia Logozzo, Uli Hauschild et al. · 2017 · BMC Oral Health

BACKGROUND: Until now, only a few studies have compared the ability of different intraoral scanners (IOS) to capture high-quality impressions in patients with dental implants. Hence, the aim of this study was to compare the trueness and precision of four IOS in a partially edentulous model (PEM) with three implants and in a fully edentulous model (FEM) with six implants. METHODS: Two gypsum models were prepared with respectively three and six implant analogues, and polyether-ether-ketone cylinders screwed on. These models were scanned with a reference scanner (ScanRider®), and with four IOS (C

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Negative / Null Result ReportOpen accessPsychology

The impact of shift work on the psychological and physical health of nurses in a general hospital: a comparison between rotating night shifts and day shifts

Paola Ferri, Matteo Guadi, Luigi Marcheselli et al. · 2016 · Risk Management and Healthcare Policy

BACKGROUND: Shift work is considered necessary to ensure continuity of care in hospitals and residential facilities. In particular, the night shift is one of the most frequent reasons for the disruption of circadian rhythms, causing…

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Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Identification of loci governing eight agronomic traits using a GBS‐GWAS approach and validation by QTL mapping in soya bean

Humira Sonah, Louise S. O’Donoughue, Elroy R. Cober et al. · 2014 · Plant Biotechnology Journal

Soya bean is a major source of edible oil and protein for human consumption as well as animal feed. Understanding the genetic basis of different traits in soya bean will provide important insights for improving breeding strategies for this…

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Negative / Null Result ReportEconomics, Econometrics and Finance

Racial Bias in Bail Decisions*

David Arnold, Will Dobbie, Crystal Yang · 2018 · The Quarterly Journal of Economics

Abstract This article develops a new test for identifying racial bias in the context of bail decisions—a high-stakes setting with large disparities between white and black defendants. We motivate our analysis using Becker’s model of racial…

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Tumor-associated macrophages-derived exosomes promote the migration of gastric cancer cells by transfer of functional Apolipoprotein E

Peiming Zheng, Qin Luo, Weiwei Wang et al. · 2018 · Cell Death and Disease

Abstract Tumor-associated macrophages (TAMs) are a major component of the tumor microenvironment and have been shown to contribute to tumor aggressiveness. However, the detailed mechanisms underlying the pro-metastatic effect of TAMs on gastric cancer are not clearly defined. Here, we show that TAMs are enriched in gastric cancer. TAMs are characterized by M2-polarized phenotype and promote migration of gastric cancer cells in vitro and in vivo. Furthermore, we find that M2-derived exosomes determine the TAMs-mediated pro-migratory activity. Using mass spectrometry, we identify that apolipopro

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Negative / Null Result ReportOpen accessPsychology

The Effect of Problem-Based Learning on the Creative Thinking and Critical Thinking Disposition of Students in Visual Arts Education

Kani Ülger · 2018 · Interdisciplinary Journal of Problem-based Learning

The problem-based learning (PBL) approach was implemented as a treatment for higher education visual arts students over one semester to examine its effect on the creative thinking and critical thinking disposition of these students. PBL…

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Negative / Null Result ReportOpen accessImmunology and Microbiology

Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease

Dermot McGovern, Michelle R. Jones, Kent D. Taylor et al. · 2010 · Human Molecular Genetics

Genetic variation in both innate and adaptive immune systems is associated with Crohn's disease (CD) susceptibility, but much of the heritability to CD remains unknown. We performed a genome-wide association study (GWAS) in 896 CD cases…

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Negative / Null Result ReportOpen accessSocial Sciences

The President and the Distribution of Federal Spending

Christopher R. Berry, Barry C. Burden, William G. Howell · 2010 · American Political Science Review

Scholarship on distributive politics focuses almost exclusively on the internal operations of Congress, paying particular attention to committees and majority parties. This article highlights the president, who has extensive opportunities,…

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Negative / Null Result ReportOpen accessPhysics and Astronomy

The NANOGrav 11 Year Data Set: Pulsar-timing constraints on the Stochastic Gravitational-wave Background

Zaven Arzoumanian, P. T. Baker, Adam Brazier et al. · 2024 · Figshare

We search for an isotropic stochastic gravitational-wave background (GWB) in the newly released 11 year data set from the North American Nanohertz Observatory for Gravitational Waves (NANOGrav). While we find no evidence for a GWB, we place constraints on a population of inspiraling supermassive black hole (SMBH) binaries, a network of decaying cosmic strings, and a primordial GWB. For the first time, we find that the GWB constraints are sensitive to the solar system ephemeris (SSE) model used and that SSE errors can mimic a GWB signal. We developed an approach that bridges systematic SSE diff

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Formation and dissociation of M 1 muscarinic receptor dimers seen by total internal reflection fluorescence imaging of single molecules

Jonathan A. Hern, Asma Baig, Gregory I. Mashanov et al. · 2010 · Proceedings of the National Academy of Sciences

G-protein-coupled receptors (GPCRs) are the largest family of transmembrane signaling proteins in the human genome. Events in the GPCR signaling cascade have been well characterized, but the receptor composition and its membrane…

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Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

The making of a pest: the evolution of a fruit-penetrating ovipositor inDrosophila suzukiiand related species

Joel Atallah, Lisa Teixeira, Raul Salazar et al. · 2014 · Proceedings of the Royal Society B Biological Sciences

Evolutionary innovation can allow a species access to a new ecological niche, potentially reducing competition with closely related species. While the vast majority of Drosophila flies feed on rotting fruit and other decaying matter, and…

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease

Lasse Folkersen, Eric B. Fauman, Maria Sabater‐Lleal et al. · 2017 · PLoS Genetics

Recent advances in highly multiplexed immunoassays have allowed systematic large-scale measurement of hundreds of plasma proteins in large cohort studies. In combination with genotyping, such studies offer the prospect to 1) identify mechanisms involved with regulation of protein expression in plasma, and 2) determine whether the plasma proteins are likely to be causally implicated in disease. We report here the results of genome-wide association (GWA) studies of 83 proteins considered relevant to cardiovascular disease (CVD), measured in 3,394 individuals with multiple CVD risk factors. We id

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Negative / Null Result ReportOpen accessBusiness, Management and Accounting

Why do people buy organic food? The moderating role of environmental concerns and trust

Anushree Tandon, Amandeep Dhir, Puneet Kaur et al. · 2020 · Journal of Retailing and Consumer Services

Although consumer interest in organic food has risen over time, resulting in a generally positive attitude toward these organic food products, scholarly research suggests a comparatively low volume of its consumption in the market. This has resulted in an urgent need to study the motivations which enhance consumers’ proclivity to purchase food items produced organically. The current research attempts to understand potential associations between motivations (intrinsic and extrinsic), attitude, and buying behaviour towards organic food. Self-determination theory (SDT) was applied to develop a th

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Negative / Null Result ReportEconomics, Econometrics and Finance

Recourse and Residential Mortgage Default: Evidence from US States

Andra C. Ghent, Marianna Kudlyak · 2011 · Review of Financial Studies

We quantify the effect of recourse on default and find that recourse affects default by lowering the borrower's sensitivity to negative equity. At the mean value of the default option for defaulted loans, borrowers are 30% more likely to…

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Negative / Null Result ReportOpen accessBusiness, Management and Accounting

Effects of Green Manufacturing and Eco-innovation on Sustainability Performance

Bülent Sezen, Sibel Yıldız Çankaya · 2013 · Procedia - Social and Behavioral Sciences

Firms are facing growing pressure to become “greener” or more environmentally friendly. Consequently, firms have had to review their production processes as a result of pressures from the community and governments. This pilot study…

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Negative / Null Result ReportOpen accessDecision Sciences

Likelihood of Null Effects of Large NHLBI Clinical Trials Has Increased over Time

Robert M. Kaplan, Veronica L. Irvin · 2015 · PLoS ONE

BACKGROUND: We explore whether the number of null results in large National Heart Lung, and Blood Institute (NHLBI) funded trials has increased over time. METHODS: We identified all large NHLBI supported RCTs between 1970 and 2012 evaluating drugs or dietary supplements for the treatment or prevention of cardiovascular disease. Trials were included if direct costs >$500,000/year, participants were adult humans, and the primary outcome was cardiovascular risk, disease or death. The 55 trials meeting these criteria were coded for whether they were published prior to or after the year 2000, wheth

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