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Browse the failure-mode index

21,165 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportEconomics, Econometrics and Finance

Are Government Spending Multipliers Greater during Periods of Slack? Evidence from Twentieth-Century Historical Data

Michael T. Owyang, Valerie Ramey, Sarah Zubairy · 2013 · American Economic Review

A key question that has arisen during recent debates is whether government spending multipliers are larger during times when resources are idle. This paper seeks to shed light on this question by analyzing new quarterly historical data…

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Negative / Null Result ReportOpen accessMedicine

Phase III Trial of Prophylactic Cranial Irradiation Compared With Observation in Patients With Locally Advanced Non–Small-Cell Lung Cancer: Neurocognitive and Quality-of-Life Analysis

A. Sun, Kyounghwa Bae, Elizabeth Gore et al. · 2010 · Journal of Clinical Oncology

PURPOSE: There are scant data regarding the effects of prophylactic cranial irradiation (PCI) on neurocognitive function (NCF) and quality of life (QOL). Radiation Therapy Oncology Group trial 0214 showed no overall survival (OS) benefit…

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Negative / Null Result ReportOpen accessMedicine

Parkinson's disease age at onset genome‐wide association study: Defining heritability, genetic loci, and α‐synuclein mechanisms

Cornelis Blauwendraat, Karl Heilbron, Costanza L. Vallerga et al. · 2019 · Movement Disorders

BACKGROUND: Increasing evidence supports an extensive and complex genetic contribution to PD. Previous genome-wide association studies (GWAS) have shed light on the genetic basis of risk for this disease. However, the genetic determinants…

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Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Nutritional value of a partially defatted and a highly defatted black soldier fly larvae (Hermetia illucens L.) meal for broiler chickens: apparent nutrient digestibility, apparent metabolizable energy and apparent ileal amino acid digestibility

Achille Schiavone, Michele De Marco, Silvia Martínez-Miró et al. · 2017 · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology

The study aimed to determine the apparent total tract digestibility coefficients (ATTDC) of nutrients, the apparent metabolizable energy (AME and AMEn) and the amino acid (AA) apparent ileal digestibility coefficients (AIDC) of a partially defatted (BSFp) and a highly defatted (BSFh) black soldier fly larvae meal. The experimental diets were: a basal diet and two diets prepared by substituting 250 g/kg (w/w) of the basal diet with BSFp or BSFh, respectively. Significant differences were found between BSFp and BSFh meals for ATTDC of the nutrients: BSFp resulted more digestible than BSFh, excep

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Negative / Null Result ReportOpen accessMedicine

Tirapazamine, Cisplatin, and Radiation Versus Cisplatin and Radiation for Advanced Squamous Cell Carcinoma of the Head and Neck (TROG 02.02, HeadSTART): A Phase III Trial of the Trans-Tasman Radiation Oncology Group

Danny Rischin, Lester J. Peters, Brian O’Sullivan et al. · 2010 · Journal of Clinical Oncology

PURPOSE: Promising results in a randomized phase II trial with the hypoxic cytotoxin tirapazamine (TPZ) combined with cisplatin (CIS) and radiation led to this phase III trial. PATIENTS AND METHODS: Patients with previously untreated stage…

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Negative / Null Result ReportMedicine

Increasing incidence of acute Achilles tendon rupture and a noticeable decline in surgical treatment from 1994 to 2013. A nationwide registry study of 33,160 patients

Ann Ganestam, Thomas Kallemose, Anders Troelsen et al. · 2015 · Knee Surgery Sports Traumatology Arthroscopy

The purpose of this study is to investigate the incidence of acute Achilles tendon rupture in Denmark from 1994 to 2013 with focus on sex, age, geographical areas, seasonal variation and choice of treatment. The National Patient Registry…

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Negative / Null Result ReportOpen accessDecision Sciences

Students’ Acceptance of ChatGPT in Higher Education: An Extended Unified Theory of Acceptance and Use of Technology

Artur Strzelecki · 2023 · Innovative Higher Education

Abstract AI-powered chat technology is an emerging topic worldwide, particularly in areas such as education, research, writing, publishing, and authorship. This study aims to explore the factors driving students' acceptance of ChatGPT in higher education. The study employs the unified theory of acceptance and use of technology (UTAUT2) theoretical model, with an extension of Personal innovativeness, to verify the Behavioral intention and Use behavior of ChatGPT by students. The study uses data from a sample of 503 Polish state university students. The PLS-SEM method is utilized to test the mod

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Negative / Null Result ReportEconomics, Econometrics and Finance

Early Impacts of the Affordable Care Act on Health Insurance Coverage in Medicaid Expansion and Non‐Expansion States

Charles Courtemanche, James Marton, Benjamin Ukert et al. · 2016 · Journal of Policy Analysis and Management

The Affordable Care Act (ACA) aimed to achieve nearly universal health insurance coverage in the United States through a combination of insurance market reforms, mandates, subsidies, health insurance exchanges, and Medicaid expansions,…

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Negative / Null Result ReportOpen accessSocial Sciences

RT to Win! Predicting Message Propagation in Twitter

Saša Petrović, Miles Osborne, Victor Lavrenko · 2021 · Proceedings of the International AAAI Conference on Web and Social Media

Twitter is a very popular way for people to share information on a bewildering multitude of topics. Tweets are propagated using a variety of channels: by following users or lists, by searching or by retweeting. Of these vectors, retweeting…

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Negative / Null Result ReportOpen accessMedicine

Human Stromal (Mesenchymal) Stem Cells from Bone Marrow, Adipose Tissue and Skin Exhibit Differences in Molecular Phenotype and Differentiation Potential

May Al-Nbaheen, Radhakrishnan Vishnubalaji, Dalia Ali et al. · 2012 · Stem Cell Reviews and Reports

Human stromal (mesenchymal) stem cells (hMSCs) are multipotent stem cells with ability to differentiate into mesoderm-type cells e.g. osteoblasts and adipocytes and thus they are being introduced into clinical trials for tissue regeneration. Traditionally, hMSCs have been isolated from bone marrow, but the number of cells obtained is limited. Here, we compared the MSC-like cell populations, obtained from alternative sources for MSC: adipose tissue and skin, with the standard phenotype of human bone marrow MSC (BM-MSCs). MSC from human adipose tissue (human adipose stromal cells (hATSCs)) and h

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Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Gut microbiota in Parkinson's disease: Temporal stability and relations to disease progression

Velma T. E. Aho, Pedro A. B. Pereira, Sari Voutilainen et al. · 2019 · EBioMedicine

BACKGROUND: Several publications have described differences in cross-sectional comparisons of gut microbiota between patients with Parkinson's disease and control subjects, with considerable variability of the reported differentially…

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Negative / Null Result ReportOpen accessSocial Sciences

COVID-19 conspiracy beliefs, health behaviors, and policy support

Valerie A. Earnshaw, Lisa A. Eaton, Seth C. Kalichman et al. · 2020 · Translational Behavioral Medicine

Conspiracy theories have been proliferating during the COVID-19 pandemic. Evidence suggests that belief in conspiracy theories undermines engagement in pro-health behaviors and support for public health policies. Moreover, previous work…

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Negative / Null Result ReportMedicine

Assessment of Quality Outcomes for Robotic Pancreaticoduodenectomy

Brian A. Boone, Mazen S. Zenati, Melissa E. Hogg et al. · 2015 · JAMA Surgery

IMPORTANCE: Quality assessment is an important instrument to ensure optimal surgical outcomes, particularly during the adoption of new surgical technology. The use of the robotic platform for complex pancreatic resections, such as the…

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Negative / Null Result ReportOpen accessMedicine

Treatment of Multisystem Inflammatory Syndrome in Children

Andrew McArdle, Ortensia Vito, Harsita Patel et al. · 2021 · New England Journal of Medicine

BACKGROUND: Evidence is urgently needed to support treatment decisions for children with multisystem inflammatory syndrome (MIS-C) associated with severe acute respiratory syndrome coronavirus 2. METHODS: We performed an international…

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Negative / Null Result ReportBusiness, Management and Accounting

Capital Allocation and Timely Accounting Recognition of Economic Losses

Robert M. Bushman, Joseph D. Piotroski, Abbie J. Smith · 2011 · Journal of Business Finance &amp Accounting

Abstract: This paper explores direct relations between corporate investment behavior and the timeliness of accounting recognition of economic losses (TLR) reflected in a country's accounting regime. We explicitly investigate the extent to…

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Negative / Null Result ReportOpen accessEnvironmental Science

Amazon forests did not green‐up during the 2005 drought

Arindam Samanta, Sangram Ganguly, Hirofumi Hashimoto et al. · 2010 · Geophysical Research Letters

The sensitivity of Amazon rainforests to dry‐season droughts is still poorly understood, with reports of enhanced tree mortality and forest fires on one hand, and excessive forest greening on the other. Here, we report that the previous…

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Negative / Null Result ReportOpen accessEngineering

Tuning Alginate Bioink Stiffness and Composition for Controlled Growth Factor Delivery and to Spatially Direct MSC Fate within Bioprinted Tissues

Fiona E. Freeman, Daniel J. Kelly · 2017 · Scientific Reports

Alginate is a commonly used bioink in 3D bioprinting. Matrix stiffness is a key determinant of mesenchymal stem cell (MSC) differentiation, suggesting that modulation of alginate bioink mechanical properties represents a promising strategy to spatially regulate MSC fate within bioprinted tissues. In this study, we define a printability window for alginate of differing molecular weight (MW) by systematically varying the ratio of alginate to ionic crosslinker within the bioink. We demonstrate that the MW of such alginate bioinks, as well as the choice of ionic crosslinker, can be tuned to contro

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Negative / Null Result ReportBusiness, Management and Accounting

Generativity Tension and Value Creation in Platform Ecosystems

Carmelo Cennamo, Juan Santaló · 2019 · Organization Science

Platform-based technology ecosystems are new forms of organizing independent actors’ innovations around a stable product system. This collective organization is proving superior to traditional, vertically integrated systems in many sectors…

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Negative / Null Result ReportOpen accessBusiness, Management and Accounting

Do organizations spend wisely on employees? Effects of training and development investments on learning and innovation in organizations

Sun Young Sung, Jin Nam Choi · 2013 · Journal of Organizational Behavior

The present study examines the effects of training and development on organizational innovation. We specifically suggest that the training and development investments of an organization affect its innovative performance by promoting…

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Negative / Null Result ReportOpen accessPsychology

Initial psychological impact of COVID-19 and its correlates in Indian Community: An online (FEEL-COVID) survey

Mohit Varshney, Jithin Thomas Parel, Neeraj Raizada et al. · 2020 · PLoS ONE

BACKGROUND: The pandemic of Corona Virus (COVID-19) hit India recently; and the associated uncertainty is increasingly testing psychological resilience of the masses. When the global focus has mostly been on testing, finding a cure and preventing transmission; people are going through a myriad of psychological problems in adjusting to the current lifestyles and fear of the disease. Since there is a severe dearth of researches on this issue, we decided to conduct an online survey to evaluate its psychological impact. METHODS: From 26th to 29th March an online survey (FEEL-COVID) was conducted u

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