Disruption of the BMEI0066 gene attenuates the virulence of Brucella melitensis and decreases its stress tolerance
Xinglin Zhang, Jie Ren, Na Li, Wenjuan Liu, Qingmin Wu · 2009 · International Journal of Biological Sciences
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Brucella melitensis is a facultative intracellular pathogen. An operon composed of BMEI0066, which encodes a two-component response regulator CenR, and BMEI0067, which encodes a cAMP-dependent protein kinase regulatory subunit, has been predicted to exist in many bacterial species. However, little is known about the function of this operon. In order to characterize this operon and assess its role in virulence, we constructed a marked deletion mutant of BMEI0066. The mutant was less able to withstand hyperosmotic conditions than wild-type (16M), but showed no significant difference with 16M whe
Abstract by Xinglin Zhang, Jie Ren, Na Li, Wenjuan Liu, Qingmin Wu, International Journal of Biological Sciences (2009) — licensed CC BY 4.0.
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