Comparison of human intestinal enteroid and zebrafish larva models for replication of human norovirus
Sahaana Chandran; Jan Vinjé; Kimberly Huynh; Kristen E. Gibson · 2026 · Applied and Environmental Microbiology
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The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
ABSTRACT Human intestinal enteroid (HIE) and zebrafish larva (ZF) models support the replication of certain strains of human norovirus (HuNoV), the leading cause of viral gastroenteritis worldwide. The replication of 17 HuNoV-positive stool specimens (nine genotypes) from patients ranging from 5 months to 83 years old was evaluated in both HIE and ZF models. The yolk of 3-day post-fertilization ZF larvae was microinjected with 3 nL 10% clarified stool suspension. Each day post-infection (dpi), 10 larvae were pooled as one sample, and two specimens were collected daily until 5 dpi. Viral RNA wa
Abstract by Sahaana Chandran; Jan Vinjé; Kimberly Huynh; Kristen E. Gibson, Applied and Environmental Microbiology (2026) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1128/aem.00152-26