Development of Three-Dimensional Human Intestinal Organoids as a Physiologically Relevant Model for Characterizing the Viral Replication Kinetics and Antiviral Susceptibility of Enteroviruses
Jessica Oi‐Ling Tsang; Jie Zhou; Xiaoyu Zhao; Cun Li; Zijiao Zou; Feifei Yin; Shuofeng Yuan; Man Lung Yeung · 2021 · Biomedicines
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Enteroviruses are important causes of hand, foot, and mouth disease, respiratory infections, and neurological infections in human. A major hurdle for the development of anti-enterovirus agents is the lack of physiologically relevant evaluation platforms that closely correlate with the in vivo state. We established the human small intestinal organoids as a novel platform for characterizing the viral replication kinetics and evaluating candidate antivirals for enteroviruses. The organoids supported productive replication of enterovirus (EV)-A71, coxsackievirus B2, and poliovirus type 3, as evide
Abstract by Jessica Oi‐Ling Tsang; Jie Zhou; Xiaoyu Zhao; Cun Li; Zijiao Zou; Feifei Yin; Shuofeng Yuan; Man Lung Yeung, Biomedicines (2021) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3390/biomedicines9010088