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Browse the failure-mode index

21,778 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Belowground Interactions in a Barley Cultivar Mixture: Root Distribution and Arbuscular Mycorrhizal Contributions to Uptake of Heterogeneous Phosphorus

Siegwart L, Müller‐Stöver D, Dresbøll DB et al. · 2025 · Physiologia Plantarum.

Cultivar mixtures have the potential to mitigate abiotic stress and stabilize crop yields, but their belowground dynamics remain poorly understood. We evaluated phosphorus (P) uptake by two contrasting spring barley (Hordeum vulgare L.)…

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Negative / Null Result ReportMedicine

Data-Driven Techniques for Estimating Energy Expenditure in Wheelchair Users.

Doshmanziari R, Strand Aandahl H, Pettersen Reierstad H et al. · 2025 · IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society

Providing feedback on energy expenditure (EE) may be an important tool to support obesity prevention among manual wheelchair users (MWU). This paper presents a data-driven approach for estimating EE based on data collected from 40…

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Negative / Null Result ReportMedicine

Responses to Hypoxia and Hyperoxia in Embryonic Tiger Keelbacks (Rhabdophis tigrinus lateralis; Colubridae).

Li XM, Su S, Zhang LW et al. · 2025 · Journal of experimental zoology. Part A, Ecological and integrative physiology

Studies examining the oxygen dependency of embryonic survival, growth, and differentiation have been conducted for decades in a diverse array of animal taxa but including only one oviparous snake, the viperine water snake Natrix maura.…

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Negative / Null Result ReportMedicine

Effect of preharvest boron spraying on the firmness and microstructure of winter-harvested frozen broccoli among maturity types.

Viriyarattanasak C, Takemura Y, Hashimoto T et al. · 2025 · Journal of the science of food and agriculture

Background Softening of winter-harvested frozen broccoli is a challenge. Application of boron (B) can improve fruit texture, but its effects on processed vegetables remain unexplored. This study is the first to investigate the impact of…

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Negative / Null Result ReportMedicine

The temporal copulatory patterns of female rat sexual behavior.

Oyem JC, Heijkoop R, Snoeren EMS · 2025 · Behavioural processes

Female sexual behavior is a naturally rewarding activity that plays an important role in reproduction and species survival. For female rats, regulating the timing of sexual interactions is essential for optimizing mating satisfaction and…

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Negative / Null Result ReportOpen accessMedicine

Limited Utility of the CALLY Index in Enhancing Mortality Prediction for Trauma Patients in Intensive Care Units: A Retrospective Analysis.

Kuo PJ, Huang CY, Liao KH et al. · 2026 · Risk management and healthcare policy

Background Accurate prognostication for trauma patients in intensive care units (ICUs) remains challenging. This study investigated whether incorporating the C-reactive protein-albumin-lymphocyte (CALLY) index into traditional ICU scoring…

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Negative / Null Result ReportMedicine

Increasing cervical penetrability in sheep by long-acting treatments with oxytocin (Carbetocin) and/or prostaglandin E2 (Dinoprostone).

Rodríguez-Piñón M, Casuriaga D, García-Barcelo G et al. · 2025 · Domestic animal endocrinology

The aim was to study the effect of long-acting treatments with oxytocin (Carbetocin, Cb) and/or prostaglandin E2 (Dinoprostone, Dp) on cervical penetrability and collagenolysis in synchronized ewes (12 days MAP-eCG). At 42 h post eCG, ewes…

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Negative / Null Result ReportMedicine

Differential Impact of Concomitant Methotrexate and Glucocorticoids Dosages on Biologics and JAK Inhibitors: The ANSWER Cohort Study.

Ebina K, Etani Y, Okita Y et al. · 2025 · International journal of rheumatic diseases

Aim This multicenter retrospective study evaluated the differential impact of concomitant methotrexate (MTX) and glucocorticoids (GCs) administration by dosage on the effectiveness and safety of biological disease-modifying antirheumatic…

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Negative / Null Result ReportMedicine

Oral Peanut Immunotherapy With Butyrate Adjuvant (OPIA) in Children: A Randomised, Controlled Trial.

Hsu PS, Barnes EH, Barnes M et al. · 2025 · Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

Background Sustained unresponsiveness (SU) remains a major challenge for peanut OIT. The short chain fatty acid (SCFA) butyrate has the potential to upregulate regulatory T cells (Tregs) to improve long term tolerance. We conducted a…

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Negative / Null Result ReportMedicine

Sigma-1 receptor antagonism as a promising strategy for postoperative pain treatment: A study in laparotomized mice.

Santos-Caballero M, Ruiz-Cantero MC, Mayr HK et al. · 2025 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Postoperative pain remains a major clinical challenge, as it often persists despite analgesic treatment even with opioids. We studied the effects of sigma-1 receptor antagonists (BD-1063 and S1RA), administered alone or in combination with…

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Negative / Null Result ReportMedicine

Patients Presenting to the Emergency Department with Bleeding in Early Pregnancy: Comparing Different Models to Predict Pregnancy Success.

Essel NOM, Couperthwaite S, Yang EH et al. · 2025 · Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC

Objectives Bleeding in early pregnancy is a common obstetric presentation in the emergency department (ED), and the outcome is difficult to predict. We developed and compared random forest machine learning (Live Birth Risk Score [LiBRisk])…

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Negative / Null Result ReportMedicine

Validation and Modified Application of the 2023 International Expert Consensus Criteria for Diagnosing Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease Among Children With Acquired Demyelination in Resource-Limited Regions.

Sondhi V, Desai N, Lingappa L et al. · 2025 · Pediatric neurology

Background This study was undertaken to validate the 2023 myelin oligodendrocyte glycoprotein (MOG) antibody (Ab)-associated disease (MOGAD) diagnostic criteria among children with acquired demyelinating syndromes. Methods In this…

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Negative / Null Result ReportMedicine

Variability in adolescent reception of parental support: Testing the domain-matching hypothesis.

Altinoz ZS, Erath SA, Pettit GS et al. · 2024 · Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43)

The present study investigated matches and mismatches between adolescent and parent socialization domains (i.e., protection, guidance) as related to adolescent reception of parental support during a laboratory-based social evaluation…

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Negative / Null Result ReportMedicine

Effects of polyphenol-rich extracts and compounds on methane and ammonia emissions from pig slurry during 28-day incubation

Vazifehkhoran AH, Pedersen J, Guldberg LB et al. · 2024 · Biosystems engineering.

Animal manure in livestock production facilities is a major source of methane (CH₄) and ammonia (NH₃) emissions from agriculture. In this study, we investigated different polyphenol-rich extracts and chemicals including commercial chestnut…

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Negative / Null Result ReportOpen accessMedicine

Acute Effects of Commercial Yerba Mate Products on Cardiometabolic Responses during Submaximal Cycling: Brewed to Perform?

Zaki S, Berkachy R, Zein Eddine R et al. · 2026 · Current developments in nutrition

Background Yerba mate ( Ilex paraguariensis ) is an herb native to South America known for its caffeine and polyphenol content, with suggested benefits for fat oxidation and energy metabolism. However, few studies have evaluated its brewed…

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Negative / Null Result ReportOpen accessMedicine

Comparative Assessment of Cartilage Quality in Human Induced Chondrocytes (hiCHOs) and Primary Articular Chondrocytes (hACs) Following Fibronectin-Based Selection.

Mazzini G, Tuerlings M, van der Stap V et al. · 2026 · Cartilage

BackgroundCell-based cartilage repair is limited by loss of chondrogenic potential during in vitro expansion. Fibronectin (FN)-based selection may enrich progenitor-like cells with better matrix-forming ability, but its long-term effect on…

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