Sigma-1 receptor antagonism as a promising strategy for postoperative pain treatment: A study in laparotomized mice.
Santos-Caballero M; Ruiz-Cantero MC; Mayr HK; Huerta MÁ; Hasoun MA; Robles-Funes M; Puerto-Moya A; Cronin SJF · 2025 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Postoperative pain remains a major clinical challenge, as it often persists despite analgesic treatment even with opioids. We studied the effects of sigma-1 receptor antagonists (BD-1063 and S1RA), administered alone or in combination with…
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Metadata source: Europe PMC · DOI 10.1016/j.biopha.2025.118298