Negative / Null Result ReportMedicine
Sivanandam P, Syenina A, Chan YF et al. · 2026 · Communications medicine
Background Mucosally-applied aminoglycosides have demonstrated host-directed antiviral activity in preclinical models through induction of interferon-stimulated genes (ISGs). However, it remains unknown if systemically administered…
View details →Negative / Null Result ReportOpen accessMedicine
Liu LT, Sun XS, Quan TT et al. · 2026 · Nature communications
Induction chemotherapy (IC) followed by concurrent chemoradiotherapy (CCRT) is the standard treatment for locoregionally advanced nasopharyngeal carcinoma (LA-NPC); however, patients with a suboptimal response to IC, defined as detectable…
View details →Negative / Null Result ReportOpen accessMedicine
Němá K, Kačúr P, Kozák T et al. · 2026 · Journal of functional morphology and kinesiology
Background: Operational performance in security-force settings depends on maintaining accurate motor-cognitive and shooting performance under acute physical strain. This descriptive pilot study examined pre-post performance patterns during…
View details →Negative / Null Result ReportOpen accessMedicine
Rasmussen CA, Mink SB, Primdahl J et al. · 2026 · Musculoskeletal care
Introduction In recent years, the Ankylosing Spondylitis Performance Index (ASPI) has emerged as a new objective measure of physical function in patients with axial spondyloarthritis (axSpA). So far, only the relative interrater…
View details →Negative / Null Result ReportOpen accessMedicine
Moabelo KC, Rauh R, Loots A et al. · 2026 · Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
We evaluated the performance of the FMDV 2.1 dry RT-rtPCR prototype assay (Tetracore) to detect foot-and-mouth disease virus (FMDV) in lymph nodes. Various masses (20-100 mg) of FMDV-negative lymph node tissue were homogenized, diluted,…
View details →Negative / Null Result ReportOpen accessMedicine
Iannuzzi S, Müller M, Yu Y et al. · 2026 · Nature communications
The human immunodeficiency virus (HIV) infected approximately 1.1 million individuals in 2024. There is no effective vaccine or cure, and funding cuts in resource-limited settings threaten treatment access. Cost-effective and widely…
View details →Negative / Null Result ReportMedicine
Ho LYW, Lai CKY, Ng SSM · 2026 · Topics in stroke rehabilitation
Background The performance fatigue index provides objective measures for assessing the impact of fatigue on performance and it may be utilized for monitoring functional outcomes in individuals with stroke; however, its psychometric…
View details →Negative / Null Result ReportMedicine
Templado S, Almela-Rojo M, Barceló MD et al. · 2026 · Hearing research
Background Pigs are increasingly used as translational models for auditory research due to anatomical and physiological similarities with humans. However, normative auditory brainstem response (ABR) parameters in commercial pig breeds…
View details →Negative / Null Result ReportOpen accessMedicine
Kavanagh EW, Joynt AT, Pion AR et al. · 2026 · JCI insight
Cystic fibrosis (CF) is a life-limiting genetic disorder caused by deleterious variants in the CFTR gene that results in altered mucus impairing the airway epithelia. Durable correction of these variants in airway cells remains a…
View details →Negative / Null Result ReportMedicine
Yin LX, Hidalgo CM, Bogan AW et al. · 2025 · JAMA otolaryngology-- head & neck surgery
Importance Circulating tumor human papillomavirus DNA (ctHPVDNA) is an important biomarker for the presence of HPV-associated oropharyngeal squamous cell carcinoma (OPSCC), but little is known about early postoperative kinetics of ctHPVDNA…
View details →Negative / Null Result ReportOpen accessMedicine
Chawana-Mutingwende TD, Ngara B, Mudadi LS et al. · 2026 · Journal of the International AIDS Society
Introduction Peripartum adolescent girls and young women (AGYW) with HIV have lower viral suppression compared to older women. But the recently introduced dolutegravir-based regimens and psychosocial peer motivation may improve viral…
View details →Negative / Null Result ReportMedicine
Giampaolo T, Liotard MG, Cadoré JL et al. · 2026 · Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
Diagnosis of canine bacterial bronchopneumonia (bBP) is challenging and mostly based on bronchoalveolar lavage fluid (BALF) cytology and bacterial culture (BC) results. However, bacterial contamination of BALF is frequent, intracellular…
View details →Negative / Null Result ReportOpen accessMedicine
Gleichenhagen J, Kaiser N, Brüning T et al. · 2026 · Journal of clinical laboratory analysis
Background Microsampling using filter cards for dried blood spots (DBS) and dried plasma spots (DPS) is a well-established technique offering practical advantages for blood collection and subsequent processing. For DBS/DPS, only a small…
View details →Negative / Null Result ReportOpen accessMedicine
Kashiv P, Balwani M, Pasari AS et al. · 2026 · Cureus
Antibody-mediated rejection (ABMR) is conventionally defined by the presence of donor-specific anti-human leukocyte antigen (HLA) antibodies (DSA), characteristic microvascular injury on allograft biopsy, and evidence of complement…
View details →Negative / Null Result ReportOpen accessMedicine
Ifeh C, Allan E, Ndiaye A et al. · 2026 · Journal of food science
This study utilized collaborations with Senegalese women farmers to investigate the impact of lactic acid bacteria (LAB) fermentation of sorghum, baobab, and milk on nutritional and sensory qualities for plant-enriched yogurt. Using a…
View details →Negative / Null Result ReportMedicine
Arovah NI, Kushartanti W, Ambardini RL · 2026 · Rehabilitacion
Background and objective Nonspecific low back pain (NSLBP) is a prevalent musculoskeletal condition. This study examined the immediate effects of extracorporeal shockwave therapy (ESWT), ultrasound therapy (UST), and shortwave diathermy…
View details →Negative / Null Result Report
Kumpas G, Brewer B · 2026 · Preprint
Abstract Between 1976 and 2016, most U.S. states adopted laws authorizing or requiring police to make warrantless arrests at the scene of a domestic violence call. These laws were intended to protect victims, but they may also deter…
View details →Negative / Null Result ReportMedicine
Cherenack EM, Larson ME, Roach ME et al. · 2026 · Brain, behavior, and immunity
Background Limited research has examined the longitudinal interplay of depression, substance use, and immune dysregulation among men with HIV. Methods We analyzed longitudinal data from 100 men who have sex with men (MSM) living with HIV…
View details →Negative / Null Result ReportOpen accessMedicine
Hoehne C, Rehling S, Schrenker J et al. · 2026 · Scientific reports
Preclinical simulation is essential for students to practice before clinical treatment. A low-cost 3D-printed model was developed with repositionable mobile maxillary anterior teeth to train periodontal splinting and evaluate learner…
View details →Failed Experiment ReportOpen accessMedicine
Bolder R, King SBS, Zahn RC et al. · 2026 · Vaccines
Background/objectives RSV is a major cause of mortality in infants, and despite recent progress to prevent RSV in the very young, an RSV vaccine for this population is still highly warranted. Clinical studies in infants in the 1960s using…
View details →Failed Experiment Report
Noble C, Geller D, Urs N et al. · 2026 · Preprint
Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have become defining therapies in the management of type 2 diabetes and obesity. Despite recent interest in the effects of GLP-1RA therapy on skeletal muscle, their influence on muscle…
View details →Failed Experiment ReportOpen accessMedicine
· 2006
Semaglutide was not detectable in the milk of mothers taking the drug subcutaneously. Their breastfed infants experienced no adverse effects. Some brands of oral semaglutide, such as Rybelsus, contain the absorption enhancer salcaprozate…
View details →Negative / Null Result ReportOpen accessMedicine
Tozawa R, Ishii N, Minamoto Y · 2026 · Cureus
Background Medial meniscus extrusion (MME) is a pivotal biomarker for knee osteoarthritis progression. Although ultrasonography offers a dynamic and cost-effective MME assessment, its clinical utility is often limited by the perceived high…
View details →Negative / Null Result Report
Stein A · 2026 · Preprint
Abstract Low-dose radiation epidemiology is contested and inconclusive: confidence intervals span zero, and point estimates shift with the chosen dose range. Part of the contest is structural, not empirical. Under the linear…
View details →Negative / Null Result ReportOpen accessMedicine
Arslan SG, Gultekinler BD · 2026 · BMC sports science, medicine & rehabilitation
Background Force platforms are widely used to assess postural stability and vertical jump performance, yet their cost and limited portability restrict routine clinical and field-based use. The Meloq EasyBase force platform offers a…
View details →Failed Experiment ReportOpen accessMedicine
McMullan RR, McGrath C, Cody N et al. · 2026 · Critical care explorations
Objectives Test the hypothesis that conservative fluid management with active deresuscitation would not adversely affect tissue perfusion or kidney injury and would be associated with reduced vascular injury compared with usual care.…
View details →Methods Dead-EndOpen accessMedicine
Carroll M, Gao Z, He L · 2026 · Foods (Basel, Switzerland)
Trace quantifications of arsenic (As) in foods by energy-dispersive X-ray fluorescence (ED-XRF) spectrometry are hindered by spectral overlap from lead (Pb) at characteristic emission lines. This study employed artificial neural networks…
View details →Methods Dead-End
De Laender F, Gonzalez A, Bleeckx O et al. · 2026 · Preprint
We provide a general theoretical explanation for a longstanding result in spatial ecology: weak dispersal among habitat patches promotes local biodiversity. Using analytical approximations of spatial Lotka–Volterra competition models, we…
View details →Methods Dead-EndOpen accessMedicine
Zips N, Kulko E, Kath-Schorr S · 2026 · Chembiochem : a European journal of chemical biology
mRNA translation can be controlled through chemical modification of the 5'-Cap, yet systematic insights into structure-reactivity relationships of bioorthogonally activatable Cap analogues remain limited. Here, we report the synthesis of…
View details →Negative / Null Result ReportOpen accessMedicine
Strauss R, Wafula ST, Kobbe R et al. · 2026 · Open forum infectious diseases
We assessed baseline C-reactive protein (CRP) and procalcitonin levels in asymptomatic individuals from malaria-endemic West Africa. C-reactive protein remained unaffected by Plasmodium falciparum parasitemia, while procalcitonin (PCT) was…
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