Browse the failure-mode index

Estimating the Opportunity for Early Detection of Ovarian Cancer Using Individual-Patient Data from a Large Randomized Controlled Trial.

Ryser MD, Holloway ST, Morsomme R et al. · 2025 · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Background The UK Collaborative Trial of Ovarian Cancer Screening did not detect a reduction in ovarian cancer mortality with either multimodal screening (MMS) or transvaginal ultrasound screening (USS) compared with no screening. The…

Hemodynamic Effects of an Increased Midodrine Dosing Frequency.

Macielak SA, Vollmer NJ, Haddad NA et al. · 2021 · Critical care explorations

In practice, midodrine has been used to reduce IV vasopressor requirements and decrease ICU length of stay. However, recent publications have failed to show clinical success when midodrine was administered every 8 hours. One possible…

EOLIA trial: the future of extracorporeal membrane oxygenation in acute respiratory distress syndrome therapy?

Sameed M, Meng Z, Marciniak ET · 2019 · Breathe (Sheffield, England)

In the EOLIA trial, early use of ECMO did not significantly improve mortality at 60 days in patients with severe ARDS, but when used as a rescue modality ECMO might help improve survival http://bit.ly/2XOjwSE.

The hazards of chasing subgroups in neutral stroke trials.

Bath PM, Howard G, Hacke W · 2025 · Neurological research and practice

Background The majority of randomised controlled trials in acute stroke and many for prevention are neutral, i.e. they failed to reach statistical significance. However, many of these will find apparent benefit in a component of a…

Melatonin and Metformin Failed to Modify the Effect of Dacarbazine in Melanoma.

Novik AV, Protsenko SA, Baldueva IA et al. · 2021 · The oncologist

Lessons learned Melatonin did not increase the efficacy of systemic chemotherapy in melanoma. Metformin did not increase the efficacy of systemic chemotherapy in melanoma. Background Current data support the possibility of antitumor…

The Usefulness of the Alpha-Defensin Lateral Flow Test in the Diagnosis of Prosthetic Infection: A Retrospective Cohort Study.

Galipienso-Eri M, Baraldés-Canals M, Aliaga-Martínez A et al. · 2025 · Indian journal of orthopaedics

Background/purpose Periprosthetic joint infection (PJI) accounts for up to 25% of failed total knee arthroplasties and 15% of the hips. The ICM18 established the criteria for the diagnosis, and the alpha-defensin lateral flow test (ADLT)…

COVID-19 testing and mental health service utilization in Ontario: a population-based cohort study.

Saqib K, Goel V, Dubin JA et al. · 2026 · International journal of public health

Objective To examine differences in mental health-related healthcare utilization for anxiety and depression between individuals who did and did not undergo COVID-19 PCR testing in Ontario. Background: The COVID-19 pandemic has been…

Cost-Effectiveness Analysis of ¹⁷⁷Lu-PSMA-617 Versus Cabazitaxel in Metastatic Castration-Resistant Prostate Cancer from a U.S. Health Care Perspective.

Gogebakan KC, Kunst N, Ghodsi A et al. · 2026 · Journal of nuclear medicine : official publication, Society of Nuclear Medicine

The TheraP trial demonstrated that 177 Lu-PSMA-617 improved progression-free survival (PFS) compared with cabazitaxel, with no significant difference in overall survival (OS). However, 177 Lu-PSMA-617 was associated with fewer severe…

Blue light and melatonin: A critical review of scientific evidence and biohacker myths in ophthalmology.

Campo-Beamud C, Roig-Ferreruela G · 2026 · Archivos de la Sociedad Espanola de Oftalmologia

Blue light is a physiological component of visible light, essential for daytime vision and circadian synchronization. There is no evidence supporting the routine use of blue-blocking glasses for preventive or therapeutic purposes. The most…

<i>Post hoc</i> analysis of a randomised, placebo-controlled, active-reference 6-week study of brexpiprazole in acute schizophrenia.

Marder SR, Eriksson H, Zhao Y et al. · 2020 · Acta neuropsychiatrica

Objective We provide a closer look at the result of a randomised, placebo-controlled, active-reference (quetiapine XR), flexible-dose, 6-week study of brexpiprazole in schizophrenia, which did not meet its primary endpoint - change from…

Patterns of Use and Benefit of Triptans in the Treatment of Acute Headache Worsening in Youth With Post-Traumatic Headache.

Shah R, Das S, Gentile Kruse CF et al. · 2025 · Pediatric neurology

Background Triptans are used to treat migraine attacks, but little to no evidence supports their use for youth with post-traumatic headache (PTH). This study evaluated patterns of use and benefit of triptans in the treatment of acute…

Does personal relevance moderate communication effects? The example of risk communication about 5G-related electromagnetic fields.

Eggeling-Böcker M, Karabetsos E, Christopoulou M et al. · 2025 · Preprint

Background: Technological advancements, such as the introduction of the fifth generation technology standard 5G, offer opportunities but also raise concerns. Although no evidence suggests negative effects of radiofrequency electromagnetic…

A Phase II, Single-Arm, Open-Label, Bayesian Adaptive Efficacy and Safety Study of PBI-05204 in Patients with Stage IV Metastatic Pancreatic Adenocarcinoma.

Roth MT, Cardin DB, Borazanci EH et al. · 2020 · The oncologist

Lessons learned This trial evaluating a novel plant extract, PBI-05204, did not meet its primary endpoint of overall survival but did show signals of efficacy in heavily pretreated mPDA. PBI-05204 was generally well tolerated, with the…

Randomized, Double-Blind Phase III Study of Pazopanib Versus Placebo in Patients With Metastatic Renal Cell Carcinoma Who Have No Evidence of Disease After Metastasectomy: ECOG-ACRIN E2810.

Appleman LJ, Kim SE, Harris WB et al. · 2024 · Journal of clinical oncology : official journal of the American Society of Clinical Oncology

Purpose Patients with no evidence of disease (NED) after metastasectomy for renal cell carcinoma are at high risk of recurrence. Pazopanib is an inhibitor of vascular endothelial growth factor receptor and other kinases that improves…

Impact of subsequent immune checkpoint inhibitor treatment on overall survival with avelumab vs docetaxel in platinum-treated advanced NSCLC: Post hoc analyses from the phase 3 JAVELIN Lung 200 trial.

Park K, Özgüroğlu M, Vansteenkiste J et al. · 2021 · Lung cancer (Amsterdam, Netherlands)

Objectives The JAVELIN Lung 200 phase 3 trial did not meet its primary endpoint of improving overall survival (OS) with avelumab vs docetaxel in patients with platinum-treated PD-L1+ NSCLC. We report post hoc analyses assessing the effects…

Does Communication Effectiveness Assessed by Communication Scholars Correlate with Patient Perception of Clinician Empathy?

Ponce H, Cordero R, Tran J et al. · 2025 · Journal of patient experience

In a prior study, communication scholar ratings of clinician communication effectiveness did not correlate with perceived clinician empathy, which is one aspect of patient experience. We repeated the analysis with a different rating of…

Association Between eHealth Literacy and Mental Health Literacy: Cross-Sectional Study.

Neter E, Youngmann R, Gruper N · 2025 · JMIR formative research

Unlabelled Associations between eHealth literacy and mental health literacy were examined; no significant association was identified between overall eHealth and mental health literacy and only weak associations between specific skills were…

Single-Cell and Plasma Proteomics Do Not Differentiate Patients With and Without SARS-CoV-2 Antigenemia in Convalescence in a Cohort of 100 Patients.

Pienkos S, Swank Z, Hamlin RE et al. · 2025 · Open forum infectious diseases

Plasma samples obtained approximately 3 ( n = 100) and 12 months ( n = 78) after acute SARS-CoV-2 infection were tested for S1, spike, and N antigens. There were no significant differences in plasma proteins or single-cell protein…

Fluoroquinolones and the risk of aortic aneurysm or aortic dissection: evidence from a nationwide nested case-control study paralleled with matched experimental models.

Wesley CD, Strange JE, Holt A et al. · 2025 · European heart journal open

Aims Fluoroquinolones (FQ) have been associated with aortic aneurysm and aortic dissection (AA/AD) resulting in an official warning. Recently, large-scale epidemiological studies failed to confirm this. Methods and results The current…

Testing the activitystat hypothesis

Physical activity has many health and psychological benefits, however many programs aimed at increasing physical activity have failed to show the expected results. This may be because when people increase their level of exercise, they…

Engineering the second generation of growth factors and cytokines for regenerative medicine applications

Growth factors and cytokines have a great potential for regenerative medicine applications. Yet, most of these molecules have failed to show efficacy in humans or raised major safety concerns, due to high dosing and inappropriate delivery…

Use of a slow-release GnRH implant in an adult billy goat.

Demattio L, Fietz D, Schuler G et al. · 2024 · Tierarztliche Praxis. Ausgabe G, Grosstiere/Nutztiere

A 9.4 mg deslorelin slow-release implant was inserted into an adult, healthy billy goat to achieve temporary infertility and a reduction in sexual behavior. The implant was inserted in late autumn. No significant change in testis size was…

Limitations of Subgroup Safety Analyses for Drug-Drug Interaction Evaluation: Insights from the Talazoparib P-gp Inhibitor Case.

Wang D, Nanavati C, Yang DZ et al. · 2026 · Journal of clinical pharmacology

Impact of concomitant medications (conmeds) on the safety of the investigational agent is often evaluated using subgroup analyses for safety events in patients who received the conmed versus those who did not. Here, we highlight the…

No reliable gender differences in attachment across the lifespan

Marinus H. van IJzendoorn, Marian J. Bakermans-Kranenburg · 2009

AbstractIn middle childhood, boys show more avoidant attachments and girls more ambivalent attachments as a prelude to gender differentiation in reproductive strategies. However, we have failed to find systematic and method-independent…

A test of the stochastic theory of stem cell differentiation

Bjerknes, M. · 1986

Stochastic theories of stem cell renewal are shown to predict turnover of intestinal crypts. While I found ample evidence of production of new crypts from direct in vivo studies in adult mice, I failed to find evidence of crypt loss. Thus,…

Sexual Function After Prolapse Repair and Retropubic Versus Single-incision Sling.

Choi, Gutman, Iglesia et al. · 2026 · Urogynecology (Philadelphia, Pa.)

Studies have shown that sexual function improves after surgical correction for stress urinary incontinence and pelvic organ prolapse. Current data suggest no significant difference in sexual function between transobturator and retropubic…

Exclusion diet vs. exclusion diet plus partial enteral nutrition in management of pediatric Crohn's disease.

Shaygantabar, Dianati, Ledari et al. · 2026 · BMC pediatrics

Exclusive enteral nutrition (EEN) induces remission in children with active mild to moderate Crohn's disease (CD), while partial enteral nutrition (PEN) with a free diet have failed to be effective in these patients. The effects of CD…

Histomorphometric bone assessment in patients with fracture of the proximal end of the femur

Caio Gonçalves de Souza, Márcio Passini Gonçalves de Souza, Vanda Jorgetti et al. · 2015 · Acta Ortopédica Brasileira

OBJECTIVE: To determine whether there is a difference on the bone architecture in patients with femoral neck fracture compared to patients with intertrochanteric fractures and assess the importance of aging on bone microarchitecture in patients with proximal femoral fracture.METHODS: Biopsy of the iliac crest was made in seventeen patients between 55 and 90 years old who were admitted to the emergency room with fractures of the proximal end of the femur. After a small fragment was removed, we made a histomorphometric analysis of it.RESULTS: There was no significant difference between patients

The Menopausal Symptoms of Paramedics at a Tertiary Care Center

Toar A Kumaat, Maria F T Loho, Eddy Suparman · 2017 · Indonesian Journal of Obstetrics and Gynecology

Objective: To assess paramedic menopausal symptoms on the inpatient unit and outpatient unit. Methods: This was a cross sectional study. Data collect by fill the questioner, the questioner fill by menopausal paramedic on Prof. Dr. R. D. Kandou Manado Hospital from October 2016 to January 2017. Data were analyzed using SPSS 22.0 for Windows. Results: Of 60 paramedics, 30 were divided to inpatient unit and the other 30 were divided to outpatient unit. By the menopause rating scale, somatic and urogenital complaint in statistical test have no significant differences. Psychology complaint with a m

Clostridium acetobutylicum atpG-Knockdown Mutants Increase Extracellular pH in Batch Cultures

Yu-Sin Jang, Hyeon Jeong Seong, Seong Woo Kwon et al. · 2021 · Frontiers in Bioengineering and Biotechnology

ATPase, a key enzyme involved in energy metabolism, has not yet been well studied in Clostridium acetobutylicum. Here, we knocked down the atpG gene encoding the ATPase gamma subunit in C. acetobutylicum ATCC 824 using a mobile group II intron system and analyzed the physiological characteristics of the atpG gene knockdown mutant, 824-2866KD. Properties investigated included cell growth, glucose consumption, production of major metabolites, and extracellular pH. Interestingly, in 2-L batch fermentations, 824-2866KD showed no significant difference in metabolite biosynthesis or cell growth comp