A Phase II, Single-Arm, Open-Label, Bayesian Adaptive Efficacy and Safety Study of PBI-05204 in Patients with Stage IV Metastatic Pancreatic Adenocarcinoma.
Roth MT; Cardin DB; Borazanci EH; Steinbach M; Picozzi VJ; Rosemury A; Wadlow RC; Newman RA · 2020 · The oncologist
WASTE classifies this as Replication Failure · AI classification, approximate
A previously reported effect did not replicate here — verify it holds before you build on it.
Abstract (excerpt)
Lessons learned This trial evaluating a novel plant extract, PBI-05204, did not meet its primary endpoint of overall survival but did show signals of efficacy in heavily pretreated mPDA. PBI-05204 was generally well tolerated, with the…
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Metadata source: Europe PMC · DOI 10.1634/theoncologist.2020-0440