Failed Experiment ReportMedicine
García-Moronta C, Rodríguez-Sanna A, Muñoz-Barba D et al. · 2026 · Dermatitis : contact, atopic, occupational, drug
Background Conventional systemic therapies, including cyclosporine and methotrexate, have traditionally been used for moderate-to-severe atopic dermatitis (AD). However, their real-world effectiveness and treatment persistence in the era…
View details →Failed Experiment ReportMedicine
Yavuz M, Unalp A, Gulagız F et al. · 2026 · Seizure
Background Ketogenic diet (KD) is an established treatment option for pediatric drug-resistant epilepsy; however, early indicators of treatment response are limited. This study aimed to explore whether early changes in routine…
View details →Negative / Null Result ReportMedicine
Boonperm P, Buaboon N, Vatanavilai C et al. · 2026 · Journal of human lactation : official journal of International Lactation Consultant Association
Background Breastfeeding is a key strategy for improving maternal and infant health; however, Thailand continues to fall short of national and international breastfeeding targets. Village Health Volunteers (VHVs) play an essential role in…
View details →Negative / Null Result ReportMedicine
Seward M, Puiras E, Crocker CE et al. · 2026 · BMC psychiatry
Background 30% of individuals with schizophrenia do not respond to first line dopamine-blocking antipsychotic medications and meet criteria for treatment resistant schizophrenia (TRS). Elevated glutamate levels in the anterior cingulate…
View details →Negative / Null Result ReportMedicine
Sinha R, Sabir M, Tripathi M et al. · 2026 · Indian journal of ophthalmology
Objective To evaluate the role of local oxygen supplementation in accelerated collagen cross-linking (CXL) in human subjects. Method Patients with progressive keratoconus were enrolled and randomized to undergo accelerated CXL in either…
View details →Negative / Null Result ReportMedicine
Vasamsetti SR, Guddeti A, Kumar S et al. · 2026 · Nigerian journal of clinical practice
Background Hypothyroidism is a common condition, and thyroid hormones play a key role in metabolism and fat regulation. We examined how levothyroxine affects visceral adipose tissue (VAT) and body composition using dual-energy X-ray…
View details →Negative / Null Result ReportMedicine
Kim S, Kim YJ, Yoon YH et al. · 2026 · International journal of retina and vitreous
Purpose This study aimed to investigate the spatial correlation between retinal structure and function in macular telangiectasia type 2 (MacTel) using Compass fundus-tracked microperimetry. Methods Medical records of 54 eyes from 28…
View details →Negative / Null Result ReportMedicine
Ting J, Grills N, Sochet AA et al. · 2026 · Pediatric cardiology
Critical congenital heart disease (CCHD) screening using pulse oximetry was mandated by all states between 2011-2018. We sought to evaluate the effect on the age at initial admission to a children's hospital, the hospital length of stay…
View details →Negative / Null Result ReportMedicine
Soliman S, Said D, Maqsood S et al. · 2026 · Advances in therapy
Introduction Infectious keratitis can lead to significant ocular morbidity and threaten vision if not treated promptly with antimicrobial therapy. Adjuvant treatment with corneal cross-linking (CXL) can improve visual outcomes in cases of…
View details →Negative / Null Result ReportMedicine
Borhany M, Iqbal HT, Abid M et al. · 2026 · Clinical medicine insights. Pediatrics
Background Sickle cell disease (SCD) is characterized by a chronic hypercoagulable state. Hydroxyurea (HU) is known to reduce the frequency of vaso-occlusive events and transfusion requirements in affected individuals. Objective To assess…
View details →Negative / Null Result ReportMedicine
Bonnet E, Ikpo D, Kodo M et al. · 2026 · Traffic injury prevention
Objective Road traffic injuries are a leading cause of death among children in Africa, especially in urban areas with inadequate infrastructure. Despite this, few scientifically taught educational initiatives to address this issue at the…
View details →Negative / Null Result ReportMedicine
Gundrosen KF, Taraldsen K, Sverdrup K et al. · 2026 · European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity
Background This longitudinal study explored the one-year change in device-measured daily physical activity in patients attending a memory clinic. Methods Physical activity was recorded in 27 memory clinic patients over four days using…
View details →Negative / Null Result ReportMedicine
Silverii H, Ahn J, Gopalan M et al. · 2026 · Journal of pediatric urology
Background While surgical coaching has been proven beneficial, the impact of a faculty focused coaching model on a surgeon's teaching ability and trainee education is unknown. In this study we aim to evaluate whether a surgeon's teaching…
View details →Negative / Null Result ReportMedicine
Gan F, Zhang Q, Luo H et al. · 2026 · Orthopaedics & traumatology, surgery & research : OTSR
Introduction The SuperPATH approach for total hip arthroplasty (THA) is promoted as tissue-preserving, but objective evidence of its impact on periarticular muscles is lacking. This study aimed to evaluate periarticular muscle damage one…
View details →Negative / Null Result ReportMedicine
Boone C, Robicsek A · 2026 · JAMA internal medicine
Importance Quality metrics with financial incentives are widely used, but their impact on clinical care and patient health remains challenging to isolate. Objective To evaluate the association of a physician-facing quality metric and…
View details →Negative / Null Result ReportMedicine
Kocuk M, Kopuz D, Alp S et al. · 2026 · American journal of dentistry
Purpose To evaluate the laboratory cleaning efficacy of six commonly used non-invasive methods for removing stains from occlusal fissures before caries diagnosis. Methods 60 extracted, caries-free permanent molars with visible occlusal…
View details →Negative / Null Result ReportMedicine
Bhakta T, Jain K, Sudanabonia P et al. · 2026 · Investigative ophthalmology & visual science
The purpose of this study was to test the hypotheses that (1) monocular blur-driven accommodation is attenuated in keratoconus due to weaker defocus-blur signals arising from degraded image quality (IQ) compared with non-keratoconic…
View details →Negative / Null Result ReportMedicine
Englisch CN, Wakili P, Langenbucher A et al. · 2026 · Journal of refractive surgery (Thorofare, N.J. : 1995)
Purpose To assess the short-term impact of stand-alone MINIject (iSTAR Medical SA) implantation on astigmatism in a single-center retrospective study. Methods Refractive and corneal astigmatism was investigated based on preoperative and…
View details →Negative / Null Result Report
shi x, Jiang B, Huang C et al. · 2026 · Preprint
Abstract Objective： To evaluate changes in ciliary muscle morphology before and after accommodative training in premyopic school-age children and assess associations with myopia-related indicators. Design: Prospective controlled study.…
View details →Negative / Null Result Report
Nie J, Chen Y, Du Y et al. · 2026 · Preprint
Abstract Background Cystic echinococcosis (CE) is a zoonotic parasitic disease caused by the larval stage of Echinococcus granulosus. The liver is the organ most commonly affected, whereas pancreatic involvement is extremely rare. When a…
View details →Negative / Null Result ReportOpen accessMedicine
Yu J, Grude O, Berg EAR et al. · 2026 · Intensive care medicine experimental
Background Measuring mitral annular plane systolic excursion (MAPSE) serially in a single wall may be an effective method for monitoring global left ventricular (LV) function, especially when automated with a novel deep learning method…
View details →Negative / Null Result ReportMedicine
Butler A, Croxford R, Owusu-Bempah A et al. · 2026 · The International journal on drug policy
Background In October 2018, Canada legalized non-medical cannabis possession and use. While a stated objective of legalization was to prevent people from entering the criminal justice system for cannabis possession, we lack evidence about…
View details →Negative / Null Result Report
Shiraiwa K, Sueshige Y, Tanaka R et al. · 2026 · Preprint
Aims: Lenvatinib (LEN) inhibits organic anion transporting polypeptide 1B1 (OATP1B1) in vitro , raising concerns about potential risk for transporter-mediated drug–drug interactions (DDIs). This study evaluated the in vivo impact of LEN on…
View details →Negative / Null Result ReportMedicine
Qian H, Jin H, Li S · 2026 · Clinical biochemistry
Objective To investigate the cause of markedly elevated cardiac troponin I (cTnI) levels that were inconsistent with the clinical presentation in an 18-year-old male patient with bradycardia. Methods Serial dilution analysis, heterophile…
View details →Failed Experiment ReportOpen accessMedicine
Montagud-Martínez R, Ruiz R, Baldanta S et al. · 2026 · Nature communications
Cas9 can process poly(T) single-stranded DNA molecules upon activation in an RNA-guided manner. Here, we uncover key determinants underlying this function. First, we show that unflanked R-loops in the RNA 5' side favor trans-cleavage…
View details →Replication FailureMedicine
Silva SJ, Romero F, Magder LS et al. · 2026 · Academic medicine : journal of the Association of American Medical Colleges
Purpose Interest in research careers among medical graduates is decreasing, and fewer physicians report research as their primary work activity. This study examines the implementation of a required scholarly research course at the…
View details →Replication FailureMedicine
Yang L, Zhuang H, Yang Z et al. · 2026 · Medical ultrasonography
Aims To evaluate the applicability of transluminal dual-plane shear wave elastography (SWE) for measuring the anal sphincter in healthy adult women. Material and methods This prospective study recruited 140 healthy women between January…
View details →Replication FailureMedicine
Albayrak D, Bulut E, Singer EA · 2026 · Lasers in medical science
This study aimed to compare the clinical effectiveness of extraoral photobiomodulation using laser and light-emitting diode (LED) in reducing postoperative pain, swelling, and improving oral health-related quality of life following…
View details →Negative / Null Result ReportOpen accessMedicine
Bellali YA, Jetté S, Delisle M et al. · 2026 · Journal of burn care & research : official publication of the American Burn Association
Paraffin wax is applied to scar tissue for its proposed benefits of increasing skin pliability and relieving pain. However, limited studies have objectively assessed hypertrophic scar (HSc) response. This study examined immediate HSc…
View details →Negative / Null Result ReportMedicine
Xu Y, Wang H, Wang N et al. · 2026 · Journal of cardiothoracic surgery
Background OBJECTIVE: To explore changes of tumor-infiltrating lymphocytes and the relationship with therapeutic effect before and after neoadjuvant chemoimmunotherapy in patients with esophageal squamous cell carcinoma(ESCC). Method This…
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