Failed Experiment ReportOpen accessMedicine
Lorenzo Porta, Sih-Shiang Huang, Chen Wei et al. · 2022 · PLoS ONE
Objectives While corticosteroids have been hypothesized to exert protective benefits in patients infected with SARS-CoV-2, data remain mixed. This study sought to investigate the outcomes of methylprednisone administration in an Italian cohort of hospitalized patients with confirmed SARS-CoV-2 infection. Methods Patients with confirmatory testing for SARS-CoV-2 were retrospectively enrolled from a tertiary university hospital in Milan, Italy from March 1st to April 30th, 2020 and divided into two groups by administration of corticosteroids. Methylprednisolone was administered to patients not r
View details →Negative / Null Result ReportOpen accessSurgery
Manasa H. Kalluri, BS, Armin Edalatpour, MD, Allison J. Seitz, MD et al. · 2026 · Plastic and Reconstructive Surgery, Global Open
Summary:. Raynaud phenomenon (RP) is a vasospastic condition of the digital arteries that can cause pain, skin color changes, and functional limitations. Although botulinum toxin is not currently Food and Drug Administration–approved for the treatment of RP, it has been used in refractory RP and has generally been found to be well tolerated. At our institution, incobotulinumtoxinA (Xeomin) and abobotulinumtoxinA (Dysport) are commonly used. Here, we report our experience with the use of incobotulinumtoxinA (Xeomin) in the hand. We present 2 cases of patients with RP in bilateral hands who pres
View details →Negative / Null Result ReportOpen accessAgriculture (General)
Clairmont Clementson, Lalita Gopaul · 2020 · International Journal of Recycling of Organic Waste in Agriculture
Purpose Vinasse is produced in large quantities as a by-product from bioethanol production. To ensure environmental sustainability, a beneficial use was sought. Previous study showed that short-term crops grown with vinasse-amended soil provided higher yield than crops treated with chemical NPK (15:15:15) fertilizer. To understand this phenomenon, this study sought to establish the nutrient release rates of vinasse in the agricultural soils of Guyana. Methods Soils representative of the three most common and one futuristic agricultural land in Guyana were fertilized with vinasse, then watered
View details →Negative / Null Result ReportOpen accessPsychiatry
Esther-Sevil Eigl, Laura Krystin Urban-Ferreira, Manuel Schabus et al. · 2023 · Frontiers in Psychiatry
BackgroundApproximately one-third of the healthy population suffer from sleep problems, but only a small proportion of those affected receive professional help. Therefore, there is an urgent need for easily accessible, affordable, and efficacious sleep interventions.ObjectiveA randomized controlled study was conducted to investigate the efficacy of a low-threshold sleep intervention consisting of either (i) sleep data feedback plus sleep education or (ii) sleep data feedback alone in comparison with (iii) no intervention.Material and methodsA total of 100 employees of the University of Salzbur
View details →Negative / Null Result ReportOpen accessEducation
Lam D. Pham · 2022 · AERA Open
Turnaround interventions often require or encourage low-performing schools to replace teachers, assuming that schools will recruit high-performing teachers who remain effective after transferring. However, teacher effectiveness may change after transferring, which could explain why some teacher replacement efforts do not improve student achievement. This paper contributes new information on the stability of teacher effectiveness by examining teachers who transfer into turnaround schools relative to teachers who transfer into low-performing but non-turnaround schools. I examine this issue by us
View details →Negative / Null Result ReportOpen accessElectrical engineering. Electronics. Nuclear engineering
Rui C. Martins, Ângelo Sacras, Sanja Jovanovic et al. · 2022 · Energy Reports
Photocatalytic oxidation is promising technology for removal of recalcitrant pollutants from water. Solar energy can be an interesting radiation source since the operating costs can be lower. However, the use of powder photocatalyst is a major drawback of the technology since suitable separation technologies are required and catalysts recovery is difficult. This work aims to test the suitability of using polymeric supports to immobilize TiO 2 in the reactor and apply it for parabens removal from water by solar photocatalytic oxidation. Polyurethanes (PU) and polydimethylsiloxane (PDMS) membran
View details →Negative / Null Result ReportOpen accessChemical technology
Ophélie Pila, Christophe Duret, Typhaine Koeppel et al. · 2023 · Sensors
The high variability of upper limb motor recovery with robotic training (RT) in subacute stroke underscores the need to explore differences in responses to RT. We explored differences in baseline characteristics and the RT dose between responders (ΔFugl-Meyer Assessment (FMA) score ≥ 9 points; n = 20) and non-responders ( n = 16) in people with subacute stroke (mean [SD] poststroke time at baseline, 54 (26) days, baseline FMA score, 23 (17) points) who underwent 16 RT sessions combined with conventional therapies. Baseline characteristics were compared between groups. During RT sessions, the a
View details →Negative / Null Result ReportOpen accessDiseases of the digestive system. Gastroenterology
Sumanpreet Kaur, Neha Jindal, Amandeep Kaur et al. · 2025 · BMC Gastroenterology
Abstract Background Colonoscopy is important for diagnosis, assessment and dysplasia screening in inflammatory bowel disease (IBD). A good bowel preparation is required for complete and adequate assessment. Trial design Randomised, assessor blinded parallel arm trial with 1:1 allocation. Methods Patients with IBD undergoing colonoscopy were randomised to control group (standard preparation with written instructions) or experimental group (additional brief video educational intervention). Outcome assessors and colonoscopist were masked to the allocation. Primary outcome was adequacy of bowel pr
View details →Negative / Null Result ReportOpen accessGeriatrics
Lars Donath, Sebastian Ludyga, Daniel Hammes et al. · 2017 · BMC Geriatrics
Abstract Background Aging is accompanied by a decline of executive function. Aerobic exercise training induces moderate improvements of cognitive domains (i.e., attention, processing, executive function, memory) in seniors. Most conclusive data are obtained from studies with dementia or cognitive impairment. Confident detection of exercise training effects requires adequate between-day reliability and low day-to-day variability obtained from acute studies, respectively. These absolute and relative reliability measures have not yet been examined for a single aerobic training session in seniors.
View details →Negative / Null Result ReportOpen accessMedicine
Zehra Abdul Muhammad, Tashfeen Ahmad · 2025 · Journal of the Pakistan Medical Association
Objective: To assess the safety and pain reduction profile of routinely prescribed oral analgesics in patients of hip fracture surgery. Method: The single-centre, prospective, cohort study was conducted from June 2022 to July 2023 at the Aga Khan University Hospital, Karachi and comprised adult patients of either gender with hip fractures. The analgesics prescribed at the time of hospital discharge and 1-week follow-up were recorded along with pain and adverse effects till the 2-week post-discharge follow-up. Pain was recorded using the visual analogue scale, with the target score set at 3/10.
View details →Negative / Null Result ReportOpen accessDentistry
Ariadne Cristiane Cabral Cruz, Mariana Lúcia Silva, Thiago Caon et al. · 2012 · Journal of Applied Oral Science
Bone morphogenetic protein type 2 (BMP-2) is a potent local factor, which promotes bone formation and has been used as an osteogenic supplement for mesenchymal stem cells. OBJECTIVES: This study evaluated the effect of a recombinant BMP-2 as well as the endogenous BMP-4 and BMP-7 in the osteogenic differentiation of adipose-derived stem cells (ASCs) in medium supplemented with ascorbate and -glycerophosphate. MATERIAL AND METHODS: Human ASCs were treated with osteogenic medium in the presence (ASCs+OM+BMP-2) or absence (ASCs+OM) of BMP-2. The alkaline phosphatase (ALP) activity was determined
View details →Negative / Null Result ReportOpen accessMedicine
Niroshica Mohanathas, Lianna Montanari, Rachel Downey et al. · 2026 · PLoS ONE
Background Multitasking, such as listening while balancing, relies on integrated processing in the sensory, cognitive, and motor systems; systems that often decline with age. Hearing loss is linked to increased risks of both falls and cognitive decline. Improving cognitive processing through executive function (EF) training may support balance, especially in older adults with hearing loss. This randomized controlled study conducted across age groups and hearing abilities, examined the effects of a 12-week EF training program on postural outcomes (center of pressure (COP)) using an auditory-cog
View details →Negative / Null Result ReportOpen accessComputer applications to medicine. Medical informatics
Vadstrup Eva S, Frølich Anne, Perrild Hans et al. · 2011 · Health and Quality of Life Outcomes
Abstract Background Type 2 diabetes can seriously affect patients' health-related quality of life and their self-rated health. Most often, evaluation of diabetes interventions assess effects on glycemic control with little consideration of quality of life. The aim of the current study was to study the effectiveness of group-based rehabilitation versus individual counselling on health-related quality of life (HRQOL) and self-rated health in type 2 diabetes patients. Methods We randomised 143 type 2 diabetes patients to either a six-month multidisciplinary group-based rehabilitation programme in
View details →Negative / Null Result ReportMedicine
Schmidt TP, Jütten K, Bertram U et al. · 2026 · World neurosurgery
Degenerative cervical myelopathy (DCM) is the leading cause of chronic spinal cord dysfunction and can lead to severe neurological impairment if untreated. While decompressive surgery is the standard treatment, predicting postoperative…
View details →Negative / Null Result Report
Naydenov A, Uzunov T, Kostadinov G et al. · 2026 · Preprint
Abstract Objectives . This study aimed to compare the efficiency and productivity of a three-dimensional Generative Adversarial Network (3DGAN) with experienced digital operators and dental students in the design of screw-retained implant…
View details →Negative / Null Result ReportMedicine
Klein J, Carl B, Schackert G · 2026 · Journal of neurological surgery. Part A, Central European neurosurgery
Objective Various studies have shown a beneficial effect of statins in patients with chronic subdural hematoma (cSDH) who do not require surgery. In surgical cohorts, however, the results of statin treatment in cSDH have been inconsistent,…
View details →Negative / Null Result ReportMedicine
Yabaş ŞM, Gümüşboğa ZŞ · 2026 · Dental traumatology : official publication of International Association for Dental Traumatology
Aim Tooth avulsion is among the traumatic dental injuries that require immediate intervention during childhood, and children are often with teachers or parents at the time of such incidents. This situation highlights the need to evaluate…
View details →Failed Experiment ReportMedicine
Hopkins S, Banks E, Bentley SA et al. · 2026 · Optometry and vision science : official publication of the American Academy of Optometry
Purpose To evaluate whether luminance-matching of non-target elements (Study 1) and incorporating artwork (Study 2) within the newly designed turtle optotype would impact visual acuity (VA) measures. Methods Study 1 evaluated the…
View details →Negative / Null Result ReportMedicine
Buis HT, Berger-Estilita J, Zirngast S et al. · 2026 · Journal of clinical monitoring and computing
Women with endometriosis are at increased risk of severe postoperative pain due to nociceptive sensitization. While multimodal analgesia reduces opioid use, the added value of objective nociception monitoring remains unclear. This study…
View details →Negative / Null Result ReportMedicine
Ismail HS, Ali AI, Soliman HAN · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]
Objective To evaluate whether differences exist in marginal adaptation among beveled and non-beveled cavity designs, different bonding-banding sequences, and before and after thermomechanical loading. Methods Forty molars received…
View details →Negative / Null Result ReportMedicine
Shirmohammadi P, Fazeli F, Zoghi A et al. · 2026 · Scientific reports
Spirulina platensis is a potential alternative food ingredient due to its bioactive compounds, nutritional composition, and a sustainable protein source. This study evaluated the effects of adding S. platensis powder (0, 0.5, 0.75, 1, 3,…
View details →Negative / Null Result Report
Chen H, Mohamed ZA, Chen R et al. · 2026 · Preprint
Abstract Background Vitamin D deficiency has been associated with tic disorders (TDs), but its neurobiological mechanisms remain unclear. This study examined whether vitamin D status is associated with cortical hemodynamic responses in…
View details →Negative / Null Result Report
Shojaei SA, Orouji M, Pakgohar A · 2026 · Preprint
This study examines the relationship between insurance market development and economic growth in 33 OECD countries over the period 2011–2021, with particular emphasis on life insurance markets and structural characteristics. To capture the…
View details →Negative / Null Result Report
Zhang X, Zou H · 2026 · Preprint
Abstract Background Sedentary behavior (SB) is a well-established risk factor for multiple chronic non-communicable diseases. However, evidence regarding its association with common ocular disorders remains limited and inconsistent. This…
View details →Negative / Null Result Report
Trujillo-Vega F, Lopez-Delgado PA · 2026 · Preprint
Background Mean platelet volume (MPV) is a simple, low-cost biomarker that reflects platelet activation. Its prognostic value in septic shock remains controversial. We aimed to determine whether MPV at intensive care unit (ICU) admission…
View details →Negative / Null Result ReportMedicine
Fernandes BP, Esteves A, Pimenta AC et al. · 2026 · BMJ case reports
Monoclonal gammopathy of renal significance is characterised by kidney injury caused by nephrotoxic monoclonal immunoglobulins produced by a pathogenic B cell or plasma cell clone. Cryoglobulinaemia in this context may lead to severe…
View details →Negative / Null Result Report
Peker¹ I, Özdemir¹ O, Kandemir¹ C et al. · 2026 · Preprint
Abstract Aim Prolonged intensive care unit (ICU) stay after coronary artery bypass graft (CABG) surgery is a significant clinical problem associated with increased morbidity, mortality, and healthcare costs. The aim of this study was to…
View details →Negative / Null Result ReportOpen accessMedicine
Zeren G, Bakır EO, Tufaro V et al. · 2026 · Journal of cardiovascular development and disease
Intravascular imaging (IVI) was introduced 35 years ago to assess coronary artery pathology and plaque vulnerability. However, from its first applications it became apparent that it can also be useful in percutaneous coronary intervention…
View details →Negative / Null Result ReportMedicine
Kim HK, Huang DT, Al-Khafaji A · 2026 · Journal of intensive care medicine
Acute liver failure (ALF) and acute-on-chronic liver failure (ACLF) both have high mortality rates without liver transplantation. Artificial liver support systems may benefit patients with liver failure, serving as a bridge to…
View details →Negative / Null Result ReportMedicine
Guo Y, Wei D, Xu S et al. · 2026 · Risk analysis : an official publication of the Society for Risk Analysis
This study examines the potential of comics as an infotainment strategy for engaging the public in climate change mitigation from the perspective of the situational theory of public. A 2 × 2 × 2 factorial experiment (N = 320) was conducted…
View details →