Failed Experiment ReportOpen accessPublic aspects of medicine
Jacqueline A. Benson MPH, Matthew Wilson MS, Aidan J. Flynn MS et al. · 2025 · Inquiry: The Journal of Health Care Organization, Provision, and Financing
The strongest risk factor for readmission to the hospital is impaired physical function. We sought to determine the usability and feasibility of a post-hospital behavioral intervention to improve mobility in older adults with significant morbidity and functional impairment. We conducted a two-arm pragmatic pilot randomized trial of a behavioral economics-informed intervention to increase daily steps in Veterans, age 60 or older, receiving home health (HH) services post-discharge. The intervention group received a multicomponent behavioral economics-informed intervention, including daily step c
View details →Negative / Null Result ReportOpen accessMedicine (General)
Michelle de Souza Rangel Machado, Tawana Vicente Bertagnolli, Eduardo Carvalho de Arruda Veiga et al. · 2020 · Clinics
OBJECTIVES: To assess the quality of life of hospitalized pregnant women with preeclampsia (PE), and compare with a group of healthy pregnant women (HP). METHODS: This was an observational cross-sectional study conducted among 58 pregnant women; 28 of them had preeclampsia and 30 were healthy. The WHOQOL-Bref questionnaire, which was divided into four aspects: physical, psychological, social, and environmental, was applied to each subject. RESULTS: A statistically significant difference was observed regarding maternal age (PE 27.8±6.2 x HG 23.0±6.6, p<0.01) and gestational age (PE 224±28.1 x H
View details →Negative / Null Result ReportOpen accessGeriatrics
Kendra Cooling, Danielle R. Bouchard, Molly Gallibois et al. · 2025 · JAR Life
Objective: To examine the effects of a standing intervention on gait speed for older adults living in long term care (LTC) residences. Design: A parallel superiority cluster randomized controlled trial. Setting and participants: LTC residences. A total of 95 LTC residents (n = 47 control; n = 48 intervention) participated in the study. Methods: LTC residences and therefore the residents from the homes were randomized to either the intervention group (standing up to 100 minutes/week) for 22 weeks or the control group (socializing with staff with no encouragement to stand for up to 100 minutes/w
View details →Negative / Null Result ReportOpen accessMedicine
Andres Montealegre, William Jimenez-Leal · 2019 · PLoS ONE
According to the social heuristics hypothesis, people intuitively cooperate or defect depending on which behavior is beneficial in their interactions. If cooperation is beneficial, people intuitively cooperate, but if defection is beneficial, they intuitively defect. However, deliberation promotes defection. Here, we tested two novel predictions regarding the role of trust in the social heuristics hypothesis. First, whether trust promotes intuitive cooperation. Second, whether preferring to think intuitively or deliberatively moderates the effect of trust on cooperation. In addition, we examin
View details →Negative / Null Result ReportOpen accessMedicine
Sung Hee Lim, Jong-Mu Sun, Joohyun Hong et al. · 2021 · The Korean Journal of Internal Medicine
Background/Aims Clinical trials have not consistently supported the use of induction chemotherapy (IC) for locally advanced head and neck squamous cell cancer. Hypopharynx and base of tongue (BOT) cancer has shown relatively poor survival. We investigated the role of IC in improving outcome over current chemoradiotherapy (CRT) in patients with hypopharynx and BOT cancer. Methods Treatment-naïve patients with stage III/IV (M0) hypopharynx or BOT cancer were randomly assigned to receive CRT alone (CRT arm: cisplatin 100 mg/m2 on D1 3-weekly, two times plus radiotherapy 68.4 Gy/30 fractions on we
View details →Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Runsheng Zhao, Kaiyu Fan, Weiqing Wan · 2023 · BMC Endocrine Disorders
Abstract Background To prevent thyroid storm and ensure surgical safety, it is imperative to regulate excessive thyroid hormone levels in patients with thyrotropin-secreting pituitary adenomas (TSHoma) prior to surgery. Somatostatin analogues (SSAs), such as octreotide, have showed efficacy in shrinking tumors, which may facilitate surgical resection. This retrospective study aimed to investigate the effect of shortterm preoperative octreotide treatment on the surgical outcome of TSHoma. Methods A total of 65 TSHoma patients from January 2010 to July 2019 were included in the study. Of these,4
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Andrea Buonsenso, Domenico Di Fonza, Gloria Di Claudio et al. · 2025 · Journal of Functional Morphology and Kinesiology
Objectives : The lat pulldown machine is one of the most versatile pieces of equipment for back strengthening, allowing variations in grip and load. However, there are significant gaps in the literature regarding the relationship between exercise modality and specific muscle activation. Methods : This study examined the electromyographic (EMG) activity of major back muscles during seven lat pulldown exercise variants that differed in grip type, width, and trunk inclination. Forty male subjects, with at least 5 years of resistance training experience, performed five repetitions of lat pulldown
View details →Negative / Null Result ReportOpen accessMedicine
Derya Sivri Aydın · 2019 · İstanbul Medical Journal
Introduction:To evaluate whether neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) have diagnostic value in endometrioma, which is a chronic inflammatory disease.Methods:A total of 187 patients who underwent surgery for adnexal mass, 97 patients diagnosed with endometrioma and 90 patients with benign cyst (corpus luteum, serous cysts or functional cysts), were included in this retrospective, comparative case series. NLR and PLR values obtained from preoperative complete blood count parameters were compared between the two groups.Results:There was no statistically significan
View details →Negative / Null Result ReportOpen accessPsychiatry
Sema Şimşek, Hasan Atak · 2021 · Psikiyatride Güncel Yaklaşımlar
In this study, the effect of 12-18 Age Family Education Program (AEP) on family functions was examined in a quasi-experimental study. The families in the experiment and control groups of the study were selected by purposeful sampling method. Self-Assessment Scale, The Family Assessment Device (FAD) and Me as a Parent Scale (MPS) were used as pretest-posttest data collection tools. A 14-session Family Education Program was carried out in the experimental group. No study was conducted with the control group. In the experimental group, it was observed that there was a significant difference betwe
View details →Negative / Null Result ReportOpen accessSpecial aspects of education
U.S.A Osuji · 2015 · West African Journal of Open and Flexible Learning
This study was carried out using a descriptive survey design to investigate the extent to which Open and Distance Learning (ODL) students in Nigeria manage their time effectively. One research question and two hypotheses were used in the study. Purposive sampling was used to select 312 ODL students from six centres across the geo-political zones of the country. The six centres were randomly selected from the zones. A 25-item Time Management Questionnaire (TMQ), in the form of a four-point Likert type scale adopted from the standardised Wayne University time management questionnaire, was used f
View details →Negative / Null Result ReportOpen accessOtorhinolaryngology
Ying Cheng, Yuzhong Zhang, Weijun Ma et al. · 2022 · Brazilian Journal of Otorhinolaryngology
Objective: Subjective Visual Vertical (SVV) and Subjective Visual Horizontal (SVH) values may reflect bilateral utricle asymmetry. Bilateral utricle static tension balance can be used to evaluate bilateral otolith lesions and otolith-related central neuropathy. Few studies have examined Virtual Reality (VR)-assisted SVV and SVH values at various head-tilt angles across age groups. The present study aimed to determine the effects of age on VR-assisted SVV and SVH values at different head-tilt angles. Methods: We divided 180 healthy subjects into 6 age groups (n = 30 in each group). VR-assisted
View details →Negative / Null Result ReportOpen accessNutritional diseases. Deficiency diseases
Arvina Dian Wahyu Permatasari, Didik Gunawan Tamtomo, Budiyanti Wiboworini · 2024 · International Journal of Nutrition Sciences
Background: In Indonesia, Acute respiratory infection (ARI) and diarrhea-related morbidity and mortality in children less than five years old still remain a significant public health concern. In this relation, energy, protein, zinc, and vitamins C, B, D, E, and A are essential nutrients to mitigate morbidity and mortality. Vitamin A was shown to play a crucial role in human development, growth, and immune function that can protect infants against infectious diseases such as ARI and diarrhea. So this study aimed to compare the effect of beef liver and vitamin A supplementation for breastfeeding
View details →Negative / Null Result ReportOpen accessDentistry
Chandramani B More, Palak H Shah · 2018 · Journal of Indian Academy of Oral Medicine and Radiology
Background: The infraorbital canal is one of the important anatomic structures present in the panoramic radiographic image which shows different radiographic presentations. Aim: To study the morphology of infraorbital canal on digital panoramic radiograph. Materials and Methods: The total of 1000 digital panoramic radiographs were selected from archives of the department after fulfilling the inclusion and exclusion criteria. Each radiograph was then analyzed for morphological study based on Scarfe et al. classification. The collected data were statistically analyzed by using descriptive statis
View details →Negative / Null Result ReportOpen accessInfectious and parasitic diseases
Jenna R. Davidson, Isra Wahid, Rusdiyah Sudirman et al. · 2019 · Parasites & Vectors
Abstract Background Sampling methodologies for mosquitoes that are capable of transmitting vector-borne infectious diseases provide critical information on entomological endpoints. Reliable and meaningful field data is vital to the understanding of basic vector biology as well as disease transmission. Various traps take advantage of different vector behaviors and are inevitably subject to sampling biases. This study represents the first comparison of kelambu traps (KT) to barrier screens (BS), barrier screens with eaves (BSE) and indoor and outdoor human landing catches (HLCs). Methods Two tra
View details →Negative / Null Result ReportOpen accessPathology
Safa Mohammed Hussein, Huda Hasan Aziz, Wurood Hameed Abed et al. · 2024 · Human Pathology Reports
Background: Hematological parameters are significantly affected by both immediate and prolonged exposure to smoking. The objective of this investigation is to evaluate the influence of cigarette smoking on hematological parameters among male students enrolled at Basrah University in Iraq. Methods: The study comprised a total of seventy male participants, divided into two groups: smokers (n = 35) and nonsmokers (n = 35). Each participant provided a 5 ml venous blood sample to analyze the complete blood count using a hematology analyzer (Spinreact, Spincell 3). Results: Cigarette smokers exhibit
View details →Negative / Null Result ReportOpen accessOphthalmology
Fabrizio Zeri, Mario De Cusatis, Luigi Lupelli et al. · 2016 · Journal of Optometry
Purpose: To investigate if the accuracy of intraocular pressure (IOP) measurements using rebound tonometry over disposable hydrogel (etafilcon A) contact lenses (CL) is affected by the positive power of the CLs. Methods: The experimental group comprised 26 subjects, (8 male, 18 female). IOP measurements were undertaken on the subjects’ right eyes in random order using a Rebound Tonometer (ICare). The CLs had powers of +2.00 D and +6.00 D. Measurements were taken over each contact lens and also before and after the CLs had been worn. Results: The IOP measure obtained with both CLs was significa
View details →Negative / Null Result ReportOpen accessMedicine (General)
Keowmani T, Lee LWL · 2016 · Patient Preference and Adherence
Thamron Keowmani,1 Lily Wong Lee Lee21Clinical Research Centre, 2Hematology Unit, Queen Elizabeth Hospital, Kota Kinabalu, Sabah, MalaysiaPurpose: To study the validity and reliability of the Malay version of the Specific Thalassemia Quality of Life Instrument (STQOLI) in Sabah’s adult thalassemia patients.Patients and methods: This cross-sectional study was done at Thalassemia Treatment Centre, Queen Elizabeth Hospital in Sabah, Malaysia. Eighty-two adult thalassemia patients who fulfilled the inclusion and exclusion criteria were conveniently selected for participation in the study. Th
View details →Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Ahmed Alnajar, MD, MSPH, Subhasis Chatterjee, MD, Jacqueline K. Olive, MD et al. · 2024 · JTCVS Open
Objective: Isolated tricuspid valve surgery is uncommon and associated with high perioperative morbidity and mortality. We aimed to study the overall outcomes of patients who underwent minimally invasive right thoracotomy tricuspid valve surgery (Mini-TVS), consisting of either tricuspid valve repair (TVre) or replacement (TVR). Methods: We performed a retrospective analysis of all Mini-TVS procedures (2017-2022), through which we identified isolated tricuspid valve surgeries. We examined in-hospital outcomes, survival analysis over a 4-year period, and competing risk analysis for reoperative
View details →Negative / Null Result ReportOpen accessSurgery
Ali Andalib · 2016 · Global Spine Journal
Introduction Although Adolescent Idiopathic Scoliosis patients have lower Bone Mineral Density (BMD) but relationship between BMD and curve pattern, intensity of curve, or its progress in these patients is controversial. Some studies have shown a significant difference between left and right proximal femur BMDs in AIS patients. Since the curve pattern relationship with density of bilateral proximal femur has not been identified, this study aims to investigate the relationship between Spinal Coronal Profile and differences in BMD on either sides of proximal femur in patients with AIS. Material
View details →Negative / Null Result ReportOpen accessSports
Ülküm Erdoğan Yüce, Özcan Saygın · 2023 · Spor Bilimleri Araştırmaları Dergisi
The aim of the study was to examine the effect of walking football applied to elderly male sedentary individuals on life satisfaction and heart rate variability. 22 male volunteers whose physical activity level was determined by International Physical Activity Questionnaire (IPAQ) were included to this study. Volunteers were divided into 11 exercise groups and 11 control groups by random sampling. While the control group had no activity participation, the exercise group performed a 20-minute warm-up, they played 60 minutes of walking football, and they performed a 10-minute cool down. This was
View details →Negative / Null Result ReportOpen accessMedicine
Chia Hassan Ali, Rozhan Yassin Khalil · 2025 · Advanced Medical Journal
Background and objectives: Various methods and devices are currently applicable to diagnose endometrial polyps with different outcomes. This study aimed to compare the efficacy of trans-vaginal ultra-sonography in relation to the rigid hysteroscopy in the diagnosis of endometrial polyps in patients with abnormal vaginal bleeding. Methods: This cross-sectional study enrolled 70 female patients with endometrial polyps at Sulaimani Maternity Teaching Hospital, Iraq, from May 01, 2022 to May 01, 2023. A well-designed questionnaire including the patient's age, gender, residency, educational level,
View details →Negative / Null Result ReportOpen accessPhysics
S. Feng, S. Feng, S. Feng et al. · 2016 · Atmospheric Chemistry and Physics
Megacities are major sources of anthropogenic fossil fuel CO 2 (FFCO 2 ) emissions. The spatial extents of these large urban systems cover areas of 10 000 km 2 or more with complex topography and changing landscapes. We present a high-resolution land–atmosphere modelling system for urban CO 2 emissions over the Los Angeles (LA) megacity area. The Weather Research and Forecasting (WRF)-Chem model was coupled to a very high-resolution FFCO 2 emission product, Hestia-LA, to simulate atmospheric CO 2 concentrations across the LA megacity at spatial resolutions as fine as ∼ 1 km. We evaluated multi
View details →Negative / Null Result ReportOpen accessMedical physics. Medical radiology. Nuclear medicine
Mohamed S. Alwarraky, Mohamed M. Abdallah, Mohamed S. Elgharbawy · 2020 · The Egyptian Journal of Radiology and Nuclear Medicine
Abstract Background To evaluate how far is selective renal artery embolization (RAE) using permanent agents effective in treating acute renal artery bleeding. We retrospectively reviewed the medical records of patients (n = 45) with renal bleeding who were managed by selective RAE using coils, N-butyl-cyanoacrylate glue (NBCA glue), and polyvinyl alcohol (PVA). Data retrieved included the cause, number, and type of the bleeding lesions as well as the results of the embolization for 1 year after RAE. Clinical success was the primary outcome while re-bleeding and complications were the secondary
View details →Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Mengyun Li, Qing Zhang, Xu Wang et al. · 2024 · Frontiers in Neurology
ObjectiveThis study aimed to analyze the clinical characteristics and prognosis of patients with autoimmune encephalitis (PWAE) who experienced seizures during the acute phase.MethodsClinical data were collected from 84 patients diagnosed with AE at the General Hospital of Ningxia Medical University between January 2015 and January 2023. Patients were divided into seizure and non-seizure groups. Clinical characteristics of both groups were compared, including differences between anti-NMDAR and anti-LGI1 encephalitis within the seizure group. Due to the limited sample size and to avoid overfitt
View details →Negative / Null Result ReportOpen accessPsychology
Aiste Dirzyte, Aidas Perminas, Aiste Skarnulyte et al. · 2024 · European Journal of Mental Health
Introduction: While personality traits and early maladaptive schemas (EMSs) can affect an individual’s behavior and well-being, the links between these constructs are under-researched, especially in non-clinical samples. Aims: Two studies were conducted to address these links, intending to explore their specifics, as previous research evidenced various associations’ models. Methods: In Study 1, the sample consisted of 120 respondents (65.0% females) living in the UK and the USA. In Study 2, the sample consisted of 244 respondents (68.0% females) living in Lithuania. In both studies, most of th
View details →Negative / Null Result ReportOpen accessMedicine
Nicholette D Palmer, Lingyi Lu, Thomas C Register et al. · 2021 · PLoS ONE
Relative to European Americans, African Americans have lower 25-hydroxyvitamin D (25OHD) and vitamin D binding protein (VDBP) concentrations, higher 1,25-dihydroxyvitamin D (1,25(OH)2D3) concentrations and bone mineral density (BMD), and paradoxically reduced burdens of calcified atherosclerotic plaque (subclinical atherosclerosis). To identify genetic factors contributing to vitamin D and BMD measures, association analysis of >14M variants was conducted in a maximum of 697 African American-Diabetes Heart Study participants with type 2 diabetes (T2D). The most significant association signals w
View details →Negative / Null Result ReportOpen accessMedicine
Jianxun Fang, Yuze Cao, Jun Ni · 2024 · European Journal of Medical Research
Abstract Background Intracranial aneurysm (IA) accounts for a substantial source of non-traumatic subarachnoid hemorrhage, with inflammation postulated as a potential factor in its pathogenesis. The present study aims at evaluating the association between circulating inflammatory cytokines and risk of IA under a bidirectional two-sample Mendelian randomization (MR) design. Methods For primary analysis, summary statistics of inflammatory regulators was obtained from a genome-wide association study (GWAS) comprising 8293 Finnish participants. Summary data of IA were extracted from a GWAS which c
View details →Failed Experiment ReportOpen accessMedicine
Nicholas J Douville, Lisa Bastarache, Emily Bertucci-Richter et al. · 2024 · PLoS ONE
Background Kidney dysfunction is a common complication in septic patients. Studies have identified numerous risk factors for sepsis-associated acute kidney injury (S-AKI), yet there is wide variability in the incidence even among patients with similar risk factors, suggesting the presence of additional uncharacterized risk factors, including genetic differences. The expansion of biobanks, advances in genotyping, and standardized diagnostic criteria have enabled large-scale, hypothesis-generating studies into the genetic mechanisms underlying S-AKI. We hypothesize that the genetic pathway behin
View details →Negative / Null Result ReportOpen accessMedicine
Franziska Emmerling, Carolien Martijn, Hugo J E M Alberts et al. · 2017 · PLoS ONE
Cognitive effort and self-control are exhausting. Although evidence is ambiguous, behavioural studies have repeatedly suggested that control-demanding tasks seem to deplete a limited cache of self-regulatory resources leading to performance degradations and fatigue. While resource depletion has indirectly been associated with a decline in right prefrontal cortex capacity, its precise neural underpinnings have not yet been revealed. This study consisted of two independent experiments, which set out to investigate the causal role of the right dorsolateral prefrontal cortex (DLPFC) in a classic d
View details →Negative / Null Result ReportOpen accessPsychology
Alberto Manzi, Yana Durmysheva, Shannon K. Pinegar et al. · 2019 · Frontiers in Psychology
Recent research by Vohs et al. (2013) garnered media attention after reporting that disordered environments increase creativity. The present research was designed to conceptually replicate and extend this finding by exploring the effect of workspace disorder on creativity. Participants were randomly assigned to work at a neatly organized (Order condition) or a messy desk (Disorder condition), where they completed several paper-and-pencil and computerized tasks, including two validated creativity measures (Abbreviated Torrance Test for Adults; ATTA; Goff and Torrance, 2002; Alternative Uses Tas
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