Negative / Null Result ReportOpen accessMedicine
Boualia B, Sandeli A, Boulebd H et al. · 2026 · ACS omega
In this research, we present the successful synthesis of benzimidazolium salts ( 2a - e ) and their corresponding selenium-NHC adducts ( 3a - e ), achieved with satisfactory yields ranging from 75% to 88%, and characterized using…
View details →Negative / Null Result ReportOpen accessMedicine
Qaid MM, Al-Garadi MA, Al-Abdullatif AA et al. · 2026 · Poultry science
Coccidiosis remains a major constraint in poultry production; therefore, this study evaluated the anticoccidial efficacy of a phytogenic blend of cinnamon bark and Rumex nervosus leaf in Eimeria tenella-challenged broilers. Birds were…
View details →Negative / Null Result ReportOpen accessMedicine
Hayashi E, Kano H, Nakamura K et al. · 2026 · Respirology case reports
Small-cell lung cancer (SCLC) has a poor prognosis, and the efficacy of tarlatamab for untreated brain metastases remains unclear. We report a case demonstrating a discrepant response between extracranial and intracranial lesions after…
View details →Negative / Null Result ReportMedicine
Wei X, Xue M, Fan B et al. · 2026 · BMC pulmonary medicine
Background Long-term changes in lung function in children with symptom control asthma are rare. To assess the trajectory of pulmonary function in children and analyze the influence factors. Methods The effects of gender, age, Body Mass…
View details →Negative / Null Result ReportMedicine
Eltahir M, Young K, Younes S et al. · 2026 · American journal of clinical pathology
Objectives Determination of B-cell clonality in formalin-fixed, paraffin-embedded tissues is challenging, especially in cases where tumor B cells are sparse. Flow cytometry is of limited utility in Hodgkin lymphomas, at least in part due…
View details →Negative / Null Result ReportMedicine
Hauck F, Herber V, Moecke S et al. · 2026 · International journal of oral implantology (Berlin, Germany)
Purpose The aim of this pilot preclinical study was to investigate the performance of a novel double-lead thread, conical bone-level ceramic implant manufactured by injection moulding (test group) in comparison to a well-established…
View details →Negative / Null Result ReportMedicine
Uğurlu İ · 2026 · Journal of clinical laboratory analysis
Background Apelin-13 and Galectin-3 (Gal-3) are bioactive mediators linked to inflammation and cardiometabolic pathways. Their clinical utility in COVID-19 alongside routine laboratory tests remains unclear. Methods In this case-control…
View details →Negative / Null Result Report
Yang B, Guo Y, Li J et al. · 2026 · Preprint
Abstract Purpose This study presents the first national-scale assessment of heavy metal contamination, ecological risks, and human health implications in paired park surface dust and soil across 40 Chinese cities over a 15 years period…
View details →Negative / Null Result Report
Rouzic FL, Lacroix J, Ehrmann A et al. · 2026 · Preprint
Abstract Background Several walking tests assess mobility and fall-related function in older adults, but their clinimetric properties remain insufficiently documented across task conditions and assessment environments. Augmented reality…
View details →Negative / Null Result ReportMedicine
Qian MY, He LY, Lan P et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
This study aimed to identify predictors of outcomes and evaluate the therapeutic impact of surgical intervention in CM patients, with a specific focus on the growing HIV-negative population in East Asia. We conducted a single-center…
View details →Replication Failure
Quispe Puma MA, Luque-Fernández CR · 2026 · Preprint
Plant-hummingbird interactions are key components of Neotropical ecosystems, yet they remain poorly documented in arid inter-Andean valleys of southern Peru, where floral resources are strongly seasonal. We evaluated the structure,…
View details →Negative / Null Result ReportMedicine
Li L, Wang C, Ji Y et al. · 2026 · Behavioral sciences (Basel, Switzerland)
Previous research suggests receiving a concurrent auditory version of text during reading, i.e., reading-while-listening, improves eye-movement behavior in less skilled readers, while disrupting skilled reading. We extended this approach…
View details →Negative / Null Result ReportOpen accessMedicine
Seiser M, Deininger C, Fierlbeck J et al. · 2026 · European journal of trauma and emergency surgery : official publication of the European Trauma Society
Purpose External fixators are essential for the surgical management of long-bone fractures, particularly in resource-limited settings where access to commercial systems is often restricted by cost and logistics. This study aimed to develop…
View details →Negative / Null Result ReportOpen accessMedicine
Batool SM, Lee H, Muralidharan K et al. · 2026 · Cancers
Characterizing the m6A epigenetic landscape is essential for understanding glioma biology, yet transcriptome-wide mapping of these modifications at isoform resolution across specific tumor subtypes has remained limited. Conventional…
View details →Negative / Null Result ReportMedicine
Chen Y, Gao L, Zheng Z et al. · 2026 · Scientific reports
Preoperative decision-making regarding extended pelvic lymph node dissection (ePLND) in prostate cancer remains challenging. Existing nodal-risk prediction tools are mainly based on clinicopathologic variables and may show suboptimal…
View details →Failed Experiment ReportMedicine
Sedlacek Miskerikova M, Houfkova A, Benkova M et al. · 2026 · ACS medicinal chemistry letters
17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) is a multifunctional mitochondrial enzyme and a potential drug target for the treatment of various pathologies, including Alzheimer's disease (AD). In this study, five new…
View details →Negative / Null Result ReportOpen accessMedicine
Alghonemy WY, Ahmed NM, Abou Samra AA et al. · 2026 · Journal of oral biology and craniofacial research
Objective To evaluate the regenerative effects of platelet-rich plasma (PRP) combined with 3% low-molecular-weight hyaluronic acid (HA) gel in treating ligature-induced periodontitis in rats. Methods •40 male albino rats divided into 5…
View details →Negative / Null Result ReportMedicine
Selim AAMA · 2026 · Natural product research
Three hydrazone chromones 3a-c ( 3a, b in trans isomer while 3c was a mixture) and three hydrazone furanochromones 7a-c ( 7a in trans while 7b, c in cis ) carrying carboxylic acid or its bioisostere sulphonamide group were synthesised.…
View details →Negative / Null Result ReportMedicine
Chen L, Liang W, Guo Y et al. · 2026 · Biomedical chromatography : BMC
Paeoniae Radix Alba (PRA, roots of Paeonia lactiflora Pall.) yields stir-baked (sbPRA), charred (cPRA), and carbonized (caPRA) specifications through increasing degrees of stir-baking. In this study, an ultrahigh-performance liquid…
View details →Negative / Null Result ReportOpen accessMedicine
Omran SA, Elnaggar MS, Youssef FS et al. · 2026 · Natural products and bioprospecting
Marine-derived Penicillium fungus gained significant attention in recent years due to their potential as a valuable source of unique natural compounds with a wide range of chemical structures and bioactive capabilities. The primary origins…
View details →Negative / Null Result Report
Burke ND, Anderson AL, Schjenken JE et al. · 2026 · Preprint
ABSTRACT Capacitation, the process whereby sperm gain the functional competence to fertilize an egg in the absence of de novo transcription and translation, is orchestrated by a hierarchy of kinases driving the phosphorylation of sperm…
View details →Negative / Null Result ReportMedicine
Kang AJ, Tseng CH, Wei MY · 2026 · The journals of gerontology. Series A, Biological sciences and medical sciences
Background Accurate case ascertainment of chronic conditions is critical for research, clinical decision-making, and population health management, especially for older adults with high multimorbidity. However, validation of ICD-based case…
View details →Negative / Null Result ReportMedicine
Joy N, Soslow JH, Crum K et al. · 2026 · Cardiology in the young
Background Pulmonary valve replacement may be required for patients with pulmonary valve disease. Exertional symptoms related to cardiovascular disease are an indication for pulmonary valve replacement; however, quantification of symptom…
View details →Negative / Null Result Report
Boscariol R, Tressoldi P · 2026 · Preprint
This preregistered study is a replication and extension of prior exploratory work comparing an Intuition Market (IM) with a traditional Prediction Market (PM) in forecasting binary financial outcomes. A previous exploratory study suggested…
View details →Methods Dead-EndOpen accessMedicine
Csonka LL, Tikkakoski A, Karjalainen J et al. · 2026 · Clinical physiology and functional imaging
Background Peak expiratory flow (PEF) obtained from dedicated PEF meters and various types of spirometers is often used interchangeably in research, despite differences in both devices and expiratory maneuver technique. The aim of this…
View details →Negative / Null Result Report
Tang L, Sun C, Chen Z et al. · 2026 · Preprint
Abstract Background This study aimed to investigate the effects of curcumin supplementation and aerobic exercise on delaying age-related skeletal muscle atrophy and to further explore their potential synergistic effects. The findings are…
View details →Negative / Null Result Report
Aghdam EB, Romeralo C, Knapp DG et al. · 2026 · Preprint
Abstract Soilborne oomycetes of the genus Phytophthora are an increasing concern in European beech ( Fagus sylvatica ) forests, where they can damage root systems and contribute to tree decline. Because Phytophthora inoculum may persist in…
View details →Negative / Null Result Report
Parmar A, Saini N, Chhatre A et al. · 2026 · Preprint
Abstract Smartphone GNSS receivers are increasingly relied upon for location-dependent workflows in surveying, citizen science, agriculture, forestry, and field-based environmental data collection. The release of raw GNSS measurements…
View details →Negative / Null Result ReportMedicine
Wadington M, Eklund K, Kilgus SP et al. · 2026 · School psychology (Washington, D.C.)
Research highlights the importance of the early identification of social, emotional, and behavioral concerns in young children; however, there are limitations regarding the usability and technical adequacy of available measures. The…
View details →Negative / Null Result Report
Tsuboi R, Murakami S, Miyata M et al. · 2026 · Preprint
Abstract BACKGROUND Dysphagia in Parkinson’s disease (PD) increases aspiration pneumonia risk and is associated with poor prognosis. Although subthalamic nucleus deep brain stimulation (STN-DBS) effectively treats motor symptoms, dysphagia…
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