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Browse the failure-mode index

21,309 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Low-Volume Versus Standard-Volume Pericapsular Nerve Group Block with and Without Dexamethasone for Postoperative Analgesia After Total Hip Arthroplasty: A Randomized Controlled Trial.

Reysner, Ciftci, Alver et al. · 2026 · Journal of clinical medicine

Background: The pericapsular nerve group block provides motor-sparing analgesia after total hip arthroplasty, but the optimal injectate volume and the role of dexamethasone remain unclear. Methods: In this prospective, randomized,…

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Negative / Null Result ReportMedicine

Hope for Romantic Relationships: Validation of a Brief Scale.

Marici, Marina, Cormoș · 2026 · Behavioral sciences (Basel, Switzerland)

This study aimed to develop and validate a brief measure of hope for romantic relationships (HRR), conceptualized as a future-oriented evaluation of relational continuity and quality. The sample consisted of 525 participants. Exploratory…

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Negative / Null Result ReportMedicine

The Effect of Acupressure on Procedural Pain, Anxiety, and Hemodynamic Parameters During Chest Tube Removal in Open-Heart Surgery Patients: A Randomized Sham-Controlled Study.

Kandemir, Yüksel, Çam Yanık et al. · 2026 · Pain management nursing : official journal of the American Society of Pain Management Nurses

Patients undergoing open-heart surgery often experience procedural pain and anxiety during chest tube removal (CTR), which can lead to serious complications, along with potential changes in hemodynamic parameters such as blood pressure,…

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Negative / Null Result ReportMedicine

Effects of Tele-Pilates Exercise on Menopausal and Urogenital Symptoms and Psychosocial Outcomes in Postmenopausal Women: A Randomized Controlled Trial.

Arslan, Tufekci, Acar et al. · 2026 · International urogynecology journal

This study aimed to examine the effects of tele-Pilates exercise on menopausal symptoms, quality of life, depression, and anxiety levels in postmenopausal women. Forty postmenopausal women were separated into two groups: as tele-Pilates…

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Negative / Null Result ReportMedicine

Characterizing the nasal microbiome using a nasal allergen challenge model.

Linton, Sjaarda, Hossenbaccus et al. · 2026 · The Journal of allergy and clinical immunology

The role of the nasal microbiome in allergic rhinitis (AR), particularly following direct allergen exposure using a controlled model, is incompletely understood. Understanding microbiome dynamics after allergen challenge could provide…

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Negative / Null Result ReportMedicine

Three-Season Analysis of Physical Performance in Professional English Football: Influence of Match Outcome, Match Location, and Players' Position During Official Competitions.

Beato, Allen, Jamil et al. · 2026 · Journal of strength and conditioning research

Beato, M, Allen, M, Jamil, M, and Vicens Bordas, J. Three-season analysis of physical performance in professional English football: Influence of match outcome, match location, and players' position during official competitions. J Strength…

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Negative / Null Result ReportMedicine

Systemic Inflammatory and Hematologic Biomarkers in Pediatric Dental Caries: Clear Group Differences with Limited Independent Association with DMFT.

Petrache, Boldeanu, Diaconu et al. · 2026 · Journal of clinical medicine

Background: Dental caries in children has been explored not only as a local oral condition but also in relation to potential systemic inflammatory changes. This study evaluated systemic inflammatory biomarkers and hematologic indices in…

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Failed Experiment ReportMedicine

Efficacy and safety of belapectin for the prevention of esophageal varices in patients with MASH cirrhosis: The randomized, placebo-controlled NAVIGATE trial.

Chalasani, Vuppalanchi, Noureddin et al. · 2026 · Hepatology (Baltimore, Md.)

Belapectin reduced variceal development in a subgroup of patients with MASH cirrhosis. We report the efficacy and safety of belapectin in patients with MASH cirrhosis and portal hypertension without varices at baseline. NAVIGATE was a…

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Negative / Null Result ReportMedicine

Efficacy of a 10-MDP-Containing Cleaner on the Bond Strength to Saliva Contaminated Dentin.

Hayashi-Wells, Phark, Duarte · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]

To evaluate the effect of saliva contamination and a 10-MDP-containing cleaner (Katana Cleaner; Kuraray Noritake, Japan) on the shear bond strength (SBS) of an ultra-mild universal adhesive applied in self-etch mode to human dentin.…

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Negative / Null Result ReportMedicine

Surgical strategy and prognostic factors in very elderly (≥ 75 Years) patients with stage I NSCLC: insights from a propensity score-matched analysis.

Lee, Chao, Shen et al. · 2026 · BMC pulmonary medicine

BACKGROUND: The optimal surgical strategy for very elderly patients (≥ 75 years) with stage I non–small cell lung cancer (NSCLC) remains uncertain. METHODS: We retrospectively analyzed 390 patients with pathologic…

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Negative / Null Result ReportMedicine

Impact of the risk-treatment paradox on in-hospital and long-term outcomes in patients with very high-risk non-ST-elevation acute coronary syndrome.

Nesova, Vorobeva, Ryabov · 2026 · The Indian journal of medical research

Background and objectives The risk-treatment paradox (RTP) has not been studied in very high-risk patients with non-ST-elevation acute coronary syndrome (NSTE-ACS). We aimed to describe the cohort of very high-risk NSTE-ACS patients,…

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Negative / Null Result ReportMedicine

Adjuvant capecitabine in women with triple-negative breast cancer with residual disease after carboplatin-containing neoadjuvant chemotherapy.

Tavares, Ramalho, da Silva et al. · 2026 · Breast cancer research and treatment

Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by early relapse and limited therapeutic options. Carboplatin added to anthracycline/taxane neoadjuvant chemotherapy (NACT) raises pathologic complete response…

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Negative / Null Result ReportMedicine

Investigating the necessity of preoperative coronary angiography for infection-related cardiac implantable electronic device explantation.

Caldonazo, Scheler, Fischer et al. · 2026 · American heart journal plus : cardiology research and practice

Device-associated endocarditis is a potentially life-threatening condition that typically requires the removal of the cardiac implantable electronic device (CIED). The role of routine coronary angiography (CAG) as part of preoperative…

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