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Browse the failure-mode index

21,309 real negative results, null findings, and replication failures. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Psychotic-Like Experiences and White Matter Microstructure: A Fixel-Based Analysis Approach With Robust Replication Across Two Cohorts.

Goodwin I, Larsen KM, Sangchooli A et al. · 2025 · Human brain mapping

Structural deficits in white matter fibre have been linked to psychosis. However, it remains unclear whether these aberrations are present in individuals that experience non-clinical psychotic-like experiences, predating illness onset.…

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Negative / Null Result ReportOpen accessMedicine

Breath-Holding Maneuvers and Airway Closure in Healthy Adults and Parkinson's Disease: Effects of Maneuver Type, Health Status, and Vocal Fold Bowing.

Curtis JA, Beam AB, Nam J et al. · 2025 · Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP)

Introduction Breath-holding maneuvers are frequently used to improve airway closure and swallowing safety in people with dysphagia. While their effects on airway closure have been studied in healthy adults, little is known about their…

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Negative / Null Result ReportOpen accessMedicine

Influence of Immobilization, Stretching, and Activity on the Morphological Properties of Spastic Gastrocnemius Muscles.

Habersack A, Kruse A, Guggenberger B et al. · 2026 · Children (Basel, Switzerland)

Background/Objectives: Children with cerebral palsy (CP) often develop altered muscle architecture and calf muscle contractures. Orthotic immobilization aims to provide prolonged stretch to lengthen the muscle belly and muscle-tendon unit…

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Negative / Null Result ReportMedicine

Effects of Time of Arrival on Trauma Patient Outcomes.

LaRosa SK, Stone XA, Fenninger AA et al. · 2024 · The American surgeon

Background Arriving during "off hours" to the hospital can put patients at greater risk of complications or mortality given lesser staff. Our goal was to investigate this in trauma patients with an Injury Severity Score (ISS) of >15. We…

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Negative / Null Result ReportMedicine

Climatic resilience: Marine heatwaves do not influence the variations of green crab (Carcinus maenas) megalopae supply patterns to a Western Iberian estuary.

Monteiro M, Azeiteiro UM, Queiroga H · 2024 · Marine environmental research

Extreme climatic events like marine heatwaves (MHWs) are becoming more frequent, intense, and longer lasting all around the world. The consequences of these anomalously warm periods are devastating for marine ecosystems. Still, little is…

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Negative / Null Result ReportMedicine

Actigraphy-based sleep and muscle sympathetic nerve activity in humans.

Bigalke JA, Greenlund IM, Bigalke JR et al. · 2024 · American journal of physiology. Regulatory, integrative and comparative physiology

Short and insufficient sleep are prevalent and associated with cardiovascular disease, with the sympathetic nervous system as a suspected mediator. The purpose of the present study was to investigate the association between objective,…

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Negative / Null Result ReportMedicine

Food processing according to the NOVA classification is not associated with glycemic index and glycemic load: results from an analysis of 1995 food items.

Basile AJ, Ruiz-Tejada A, Mohr AE et al. · 2024 · The American journal of clinical nutrition

Background Ultraprocessed foods (UPFs) comprise most calories in the United States diet. Glycemic index (GI) and glycemic load (GL) are measures of the quality and quantity of carbohydrates in food based on their effect on postprandial…

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Negative / Null Result ReportMedicine

Daily exposure to combat-related cues and posttraumatic stress symptoms among veterans: Moderating effects of peri- and postdeployment experiences.

Mojallal M, Simons RM, Simons JS et al. · 2024 · Journal of traumatic stress

One of the central symptoms of posttraumatic stress disorder (PTSD) is a heightened reactivity to trauma cues. The current study used experience sampling to investigate the associations between exposure to combat-related cues and PTSD…

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Negative / Null Result ReportOpen accessMedicine

Altering visual feedback during reaching: no mitigating effect on pain for individuals with complex regional pain syndrome, but visuomotor adaptation is preserved.

Dagenais M, Sutter C, Brun C et al. · 2025 · Frontiers in human neuroscience

Introduction Complex regional pain syndrome (CRPS) is often associated with pain-related fear of movement, and virtual reality has been proposed as a potential rehabilitation intervention to overcome this issue. Therefore, this…

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Negative / Null Result ReportMedicine

Primary Care Physicians' and Hospitalists' Experience with Advance Care Planning with South Asian Canadian Older Adults before and during COVID-19.

Vashisht A, Gutman G, Mackey D et al. · 2024 · Canadian journal on aging = La revue canadienne du vieillissement

Few older adults discuss their end-of-life care wishes with their physician, and even fewer minorities do this. We explored physicians' experience with advance care planning (ACP) including the barriers/facilitating factors encountered…

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Negative / Null Result ReportOpen accessMedicine

Association of LR treatment response category with outcome of patients with hepatocellular carcinoma on explant pathology.

Khurana A, Chai N, Gibson A et al. · 2025 · Abdominal radiology (New York)

Objectives Liver transplant (LT) is an effective treatment for hepatocellular carcinoma (HCC) in appropriately selected patients. Locoregional therapy (LRT) is often performed to extend a patient's eligibility for LT. Imaging has a modest…

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Negative / Null Result ReportMedicine

Neonatal hyperoxia exposure does not exacerbate hypertension programmed by maternal obesity.

do Carmo JM, Hall JE, Dai X et al. · 2026 · American journal of physiology. Regulatory, integrative and comparative physiology

Maternal obesity increases the risk of preterm delivery and rapid transition of offspring from a hypoxemic environment to a normal or elevated oxygen environment, especially if the baby receives oxygen therapy. Maternal obesity may also…

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Negative / Null Result ReportOpen accessMedicine

Duration and mode of delivery: Does maternal sleep matter?

Parttimaa H, Paavonen EJ, Perasto L et al. · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

Objective Poor sleep quality in late pregnancy has been identified as a risk factor for operative deliveries. In this study, we investigated the associations between maternal sleep throughout pregnancy and its impact on both the duration…

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